5IY6,2XPL


Conserved Protein Domain Family
Med26

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pfam08711: Med26 
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TFIIS helical bundle-like domain
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.
Statistics
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PSSM-Id: 400862
View PSSM: pfam08711
Aligned: 430 rows
Threshold Bit Score: 32.4915
Threshold Setting Gi: 297323581
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IY6_U         26 DLLKELKNIpmTLE-LLQST-RIGMSVNAIRKqs-tDEEVTSLAKSLIKSWKKLL 77   human
XP_003329774  230 ELLSKMSID----TqSLKSS-ELGKIVLFYTKcprvDPTIKRMADQLVTRWIKPI 279  Puccinia graminis f. sp. tritici CRL 7...
XP_006956611  209 QILSNMYID----TqSLKSS-KLGPVILFYSRhprvNKSIKKAADALVTRWMRPL 258  Wallemia mellicola CBS 633.66
EGG00925      246 QLLSKMTID----TqSLKSS-ELGKVIVFYTKckrvDPSIKRLADNLFTTWLRPI 295  Melampsora larici-populina 98AG31
XP_002953870  392 KVISCLKMLpiDLI-ALKGS-SIGQTVGKLRkh--tNQAVRAAAAELVDQWKSVV 442  Volvox carteri f. nagariensis
XP_005843549  216 KTLACLHKLpvTLA-ALQPPcELGKIVGRLRKhesfGSPVIEPAKRLVVRWKAMV 269  Chlorella variabilis
XP_002442140  522 AMLRALARLpiNLS-ALQRC-SIGKSVNRLRGh--kNVEIQKKSRLLIEDGKRRI 572  sorghum
EMS57446      185 ALLRALVKLpiNLN-ALQSC-SIGKTVNHLRSh--kDQEIQRNARCLVDSWKKRV 235  Triticum urartu
XP_003027984   32 NILHELDVYskPPE-ALGPS-LLGLTVGKLRYh--eTEEVSERAKALVARWMAAA 82   Schizophyllum commune H4-8
XP_018686011  101 ALLRALDKLpvNLN-ALQSC-NIGKSVNHLRNh--kNPEIQKKARSLIDTWKKRV 151  wild Malaysian banana
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