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Vps51/EXO84/COG1 N-terminal This entry represents a conserved domain found in a number of components of multisubunit tethering complexes. Complexes associated with tethering containing helical rods (CATCHR) include exocyst, COG, GARP, and DSL1 complexes, which share a common origin reflected in their structure and organisation similarities. CATCHR share a fold consisting of helical bundles arranged in tandem towards the C-terminal and they usually have a coiled-coil (CC) region at the N-terminal. Each complex has a specialised function at a particular location in the secretory pathway, including vesicle recycling. This domain is found at the N-terminal of Vps51 (also known as Vps67), a subunit of GARP and interacts with the SNARE Tlg1, Exo84/Exo8 from the exocyst and COG1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",