5EAN


Conserved Protein Domain Family
Dna2

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pfam08696: Dna2 (This model is not part of the current CDD release)
DNA replication factor Dna2
Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways.
Statistics
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PSSM-Id: 518441
Aligned: 125 rows
Threshold Bit Score: 121.137
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5EAN_A         75 SQDREHEVLCILRNGW-SSVP-VEPGDIVHL--------EG-DC----TSEPWIIDD--DF------------G-YFILY 124  house mouse
XP_001308336   79 PGLGHSERYVHLRGQW-ATSS-ISIADPCFIvgkwelgdDP-VGnvyqNKYYTIIDD--AN------------G-FFISL 140 
Q9U3F2        122 IDKEGTTRIVYLQDHW-SEMS-IEAGSTINLigaqa-----------wgdrDFLVND--DV------------G-IVILN 173  Caenorhabditi...
2_pfamImport    1 KDKDGKIRMVYLQDIW-SEVP-VEEGNKINLiaakk-----------weedDFIVDD--EQ------------G-IVILN 52  
EFO86185      129 VDKNGKTRLVYLQDRW-SELD-IEVGNTINLigpek-----------wgddDYIAND--TK------------G-IVILN 180 
XP_045092118  147 VDKQRKTRVIYLQDQW-AELD-VEVGNAINLiapqv-----------wgndDYIVNN--QK------------G-IVILN 198 
A0BNB9         97 FGDNQKTIEIFLFDHY-NNLKqIRKGMQIRVngefi------------dsraIIFTQkiQN------------KnSFTLE 151  Paramecium te...
WP_049954046   56 SVDGKDARTVTLWGKWtESAAlLEPG--IEL----------------------LVTNveEDeyqgetqysttgDsYVVVE 111  Halostagnicol...
XP_003063745  422 GGGGGGTKTLRLHDMW-AETC-VRAGDLVRVvaggssasgggasqpgsecgEDVVDVrgGGgg---------vGkVLIHH 490 
XP_649299      37 EQQEKKQFILYLDDLW-YETS-LKVGDFIHLifleertk-------nslpnpfILNN--RT------------PiLLIQN 93   Entamoeba his...
5EAN_A        125 PDMMISGTSVASSIRCLRRAVLSETF--RGSDPATRQMLIGTILHEVFQKAI------SE--S--------------FAP 180  house mouse
XP_001308336  141 PHVLISGTEMATAQRCRRQTYINSVCpeRI---SNMDMFRGSICHILLQRVF------FG-----------------LRN 194 
Q9U3F2        174 PDALVPCTAVASATFCARKTVLNDKF--KFGNASNKAMLLGTIMHEIFQTAI------TS-----------------KKR 228  Caenorhabditi...
2_pfamImport   53 PNALVPCTAVASASWCMRKTVLNERF--KFGNASNKAMLLGTIMHEIFQSAI------IS-----------------KKR 107 
EFO86185      181 PNALVPCTAVASSLFCSRKVILNDKF--KFGNASNKAMLLGTIIHEIFQTAI------TS-----------------KKR 235 
XP_045092118  199 PNALVSCTAVASATFCARKTILNEKF--KFGNASNKAMLLGNIVHEIFQTAI------TN-----------------KKR 253 
A0BNB9        152 PETLVAPSILNGLDFCRRKQFTREFFqnQCFG-TTLEMLSGKILHDFFQNIImdvksyDSlfEnieqldehqkdlqqLVV 230  Paramecium te...
WP_049954046  112 PSFLVNVTAVRNWVECPRLYYLNKLSgv----pLNYPVVKGTIVHEVFGDLL--------------------------RG 161  Halostagnicol...
XP_003063745  491 PQVLVSSTAVGGSMQCLRRTILQTTVpdGGGGDHSAAAMLGTLSHELSEASLeaawsdSG-----------------PGA 553 
XP_649299      94 PDYLINTTSTVSSTWCNRQTVIKNYL---FLDDYYEATTLGTIIHGTIQHILi-----TNppE--------------FNK 151  Entamoeba his...
5EAN_A        181 ERLQELALQTLRe--vRHLKEMYRLNLS-QDEILCEVEEYLPSFSKWAEDFMR----KGPSSEFPQMqlslpsdgSNRSS 253  house mouse
XP_001308336  195 QDIDHTLDQLLE----SSKYELFLMEET-KESAKSTIIPYLETIRLIADAIET----NSN-------------------- 245 
Q9U3F2        229 PVMENDLMKIWNkqapKYAEELVALSFT-PSCLDAELQPYFSIICGWINKHYP----LSNSFFSKRE--------PLPS- 294  Caenorhabditi...
2_pfamImport  108 PIVESDLLKIWStqapKYAEELVALSFT-PNCLISELEPYFSIISEWINKHYP----ISNSFFRKKE--------PLPS- 173 
EFO86185      236 PLVEDNLLQIWNtqapKYAEELVALSFT-PSCLNVELKPYFSVICDWINKHYP----LSNSFFTKRE--------QLPS- 301 
XP_045092118  254 PLVDSDLLKIWTtqapKYAEDLVALSFT-PTCLDAELQPYFSVICNWINKHYP----TSTGLFTKRE--------PLPS- 319 
A0BNB9        231 ENLPQSFLQPISqlysKYIQEFYHLEKKtVREMLINIIPKCVNTLRWIQQFVI----KQQPISLKQQ--------KSSDV 298  Paramecium te...
WP_049954046  162 RDLEAAIDERID----ERGLELGLLGET-PEAVAEDVRDNAAAIEGWLEQGRL----TEEDGAATAA--------DNPER 224  Halostagnicol...
XP_003063745  554 KGFFKHSAALVD----ASSARLFGAGVT-EKEALDRLRYVGPGVHKWTRQLVRpalkKSNQPASTVA--------GVACK 620 
XP_649299     152 TIFKSMIEELSE----ELLTKVYVLGIT-RKEFIDHAMEFYDTVNNWYQCWKT----KTIKTNLNR-------------- 208  Entamoeba his...
5EAN_A        254 PC---------NIEV-------------------VKSLDIEESIWSPRFGLKGKIDVTVGV 286  house mouse
XP_001308336  246 -----------KFTLdhrlfngiatpiealppygAKTVQEEENIWSFQWGLKGKIDATMEK 295 
Q9U3F2        295 -----------KSEL-------------------LEVYDIEENIWDSKLGLKGKIDVTMRT 325  Caenorhabditis elegans
2_pfamImport  174 -----------KSVL-------------------LEVHDIEENIWDSRLGLKGKVDVTMRT 204 
EFO86185      302 -----------KSEL-------------------LEVYDIEENIWDSKLGLKGKVDVTMRT 332 
XP_045092118  320 -----------KSQL-------------------LEVHDIEENIWDSKLGLKGKVDVTMRT 350 
A0BNB9        299 F----------KIKI-------------------LKWVSNEQLISSSVYGLKGFIDVVVQV 330  Paramecium tetraurelia
WP_049954046  225 AFtp-----------------------------aEGSWRSEQLLISETFGIRGRADAVRRG 256  Halostagnicola larsenii
XP_003063745  621 VLngpgrasrgVVSA-------------------LRVVTAEETVWAPRLGLKGVVDAVAVG 662 
XP_649299     209 -----------EIHF-------------------SEFIASEPQIQSQIFGFKGAIDILLND 239  Entamoeba histolytica HM-1:IMSS
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