Conserved Protein Domain Family
SKG6

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pfam08693: SKG6 
SKG6 family
SKG6/Axl2 are membrane proteins that show polarised intracellular localisation. SKG6_Tmem is the highly conserved transmembrane alpha-helical domain of SKG6 and Axl2 proteins,. The full-length fungal protein has a negative regulatory function in cytokinesis.
Statistics
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PSSM-Id: 489809
Aligned: 9 rows
Threshold Bit Score: 706.141
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003684010  68 C--GTAKCTYPADHSYST--TVGVAVGVPVGVILVIFVVILCVLYKRKKRDEKEDNDPDFVGDAEYIPNINNKhsrFPgg 143
Q6CN21        27 CtgSSQHCEKPSDSTNTT--AVVVAVVVPVVVVGLVLIFILYKVYKRNKKEELEDNDPDFDGDAEFLPDFGQE---FE-- 99  Kluyveromyces l...
SCW00807      37 KcaSGSSCQKSESADNST--GVVVAVVVPVVVAILALAFVLWKVWRRGKKEALEDNDPDFEGDDEFLPNFGPQ---YE-- 109
CEP63136      41 ChgSG--CAKPSDDTQSY--AVAIAVVVPVFVVCLILAFVFYKVWKRGKKEAIEDNDPDFDGDGDYLPPDDHL---AK-- 111
XP_001647054  46 ScgGDGKCRYPSDHSYST--TVGVAVGVPVAVVVFLLAAILIIVYKRNKKEAEEDNDPDFQGDIEYIPHMGPNmgsFP-- 121
XP_003957497  43 CtgTKQECEKPTDSTMDV--TVAVAVVVPVAVIIIVLSVILFMVYRRSKKEAQEDNDPDFDGDAEFISNG------YA-- 112
P32900        53 CtgSKQQCQLPTDSSHSTsvTVGVAVAVPVGVIIIVLAVILCIVYRRSKKEAEEDNDPDFEGDSEFLPTMKD----YS-- 126 Saccharomyces c...
EJS43383      56 CtgSNQSCQLPADSSHSTnvTVGVAVAVPVGVIIIVLGVILYIVYRRSKREAEEDNDPDFEGDSEFLPAMND----YP-- 129
XP_056088245  54 CtgSKQSCELPTDSNHSTnvTVGVAVAVPVGVIIIVLAVILYIVYRRSKKEAEEDNDPDFEGDSEFLPAMHN----YI-- 127
XP_003684010 144 kfthgdmyniPNSSEIGSFDLKNDYNDDVQYlasdnaRSN-NPFSNPSQr----------NLVEKSNMRVPTYVP-ENID 211
Q6CN21       100 ----------MERNVDPSGMRIPSSATRAFS------VQP-NPFNDETK-----------SFAYSQSATNPFQLPtVTDD 151 Kluyveromyces l...
SCW00807     110 ----------LRENGVRGMGSASNFDDLES-------RTPqNPFASNYMgg--------nASINTGLPLDPFQLP-QGND 163
CEP63136     112 ----------FRERSAPGTFSDSNFDELELKsq--srTTPsNPYTPT----------------NAGFPLNPFQLP-RGDD 162
XP_001647054 122 ----------MSSSQSGDSFELKDDQYRDTYfm---pPPQqNQYARATSfg--------gGGIDNYGHLDPFQVP-HGVD 179
XP_003957497 113 ----------MKHNFEGSNDSQHDMKEEFNQayyqtgRPEeNPFNENYN--------------DHTWSVNPFKLP-ETAD 167
P32900       127 ----------PGINHLYSSDSQQDFMEKTLQ------QPPsDPFVGSMHsskynvrsatpPAIGRSWYVDPFQLPqESND 190 Saccharomyces c...
EJS43383     130 ----------SGTNHPYSSDSQQDFLEKTLQ------QPPtDPFANSLDgsrynvrsttpSGIARPRYIDPFQLPqESSD 193
XP_056088245 128 ----------PGMNHPYSSDSQQDLVEKALH------QPPsDPFADSMDnmrs----vtpPGIGQSWYVDPFQLPqESSD 187
XP_003684010 212 TFALRDYANNIDGPaDLGAYKLAS---KNHSLVSLTSNAYSTSNKNSYINLSQSNGLS---------------------- 266
Q6CN21       152 SETLRNFAKTFQNS-DFDGYKLAT---RSASQISISRPTSAAGGSVPNNGNIQLSNLSkfst---------------vsn 212 Kluyveromyces l...
SCW00807     164 TNDLRAFARNIQSA-EFDGYRLAS---RNASEHSLSYPESRFSRPQALNSQGRLASFTssnsqsmgsspvdynqgkeqgl 239
CEP63136     163 ADELRSFARSINNH-EMDAYRLAS---RNVSEASLVHSDSALQRPQIFAQNGRSHSFT---------------------- 216
XP_001647054 180 SNTLRDFARSVDGP-SIGGYHVASs-sKNTSQISLTNE----QPTNVFMSQGDINSVEpg------------------kf 235
XP_003957497 168 AGSLRNFAREIEND-KVGGYQLAHiqsRVASSSSLALDQ--IGRGSFAARNGSAVGMS---------------------- 222
P32900       191 SNSLRDFAMRVQED-GLGGYKVAAe-sRNASQTSLH--------PDNFSNCTPIRASSr--------------------- 239 Saccharomyces c...
EJS43383     194 SNSLRDFAMKVQSD-GFGGYKVAAs-sRNASQTSLH--------PDNFSSHTQIRESTgf------------------tg 245
XP_056088245 188 SSSLRDYAMKVQSD-GFGGYKAAAn-sRNASQMSFH--------PDSFYTPVRAPSR----------------------- 234
XP_003684010 267 NAPPPSQSIGSQNYDIKRASIFTSDTDNESTHSKIMQSPVKSVLGNTTQHygqdVSGYDIDTSKLDNTN-DFTFENDYDN 345
Q6CN21       213 GNNSNGDDKILKYSEIVQDSGSPADEDDDDDEEDSKDSDLYSEPSPVKYS----RGNVTQSYIHQDQEGfQPEVSMQESE 288 Kluyveromyces l...
SCW00807     240 YNEKNSK--TDQKSYSDSSRDLSPAQNAQDESFEFEKSPIKNARGDVTQGyvnsNVGLDAEKSFGDHDSfEFQDSSETRE 317
CEP63136     217 SSNMISVESASDWAPNNRDRVSQTSEMADDSTSDLENSPIKRAPVDVKLGyvnnPVGLDPEKSERESDSlESSHNANSDN 296
XP_001647054 236 AQSRDAL----LSGEYEEENNFPSTNHDQSMVSNIRDSPVKSVVGEATRFygddESGYDVEESKIQDTTiERSQSSQHEF 311
XP_003957497 223 IHNRSGLDMVGNVTPSRQSETDVASTSSPGEYNNYKESPLQNKGNRENVPlsieSIGIKNDENVVESNy-DARTKQKSQN 301
P32900       240 FQESESF--RSHGSPIHNNQLSRGS-ATEGANKQFTFPNEDNDSSSVSEE----AEVLNESNESASNDAfEFELDNSSEK 312 Saccharomyces c...
EJS43383     246 FQGNEGT--QSQFSPIDDSRIAGDFDATTDAHKRSNDSKAASDSATISKE----IAVSIESDESPDNDAfEFEFDNGSEK 319
XP_056088245 235 FQEDGSI--QSHASPVDKNQVFSGF-ATGDAHKQSHVPYEVNDTATVSKK----GGGSDESEESSSNDAfEFELDNNSEM 307
XP_003684010 346 NRNSTILPQEN---LeikdlesieldgngehnvtvNSEDKVYS--LETEEDENIRRLKSIYNVYLDRNNTVRQTSGNqnv 420
Q6CN21       289 RTSEGIQLQKKp-fL--------------------ENEDDVYIqrDEEDSDEDVARMKSIYQVYLDRNGTVKTIREG--- 344 Kluyveromyces l...
SCW00807     318 SDLASAQIQNEeien-----------------vpaNVDDDVYAskL-TKEEENIKRMKSIYEVYLDRQKTMKSDRGNrde 379
CEP63136     297 HHREGTTNFEN------------------------DESEEVF---LTSKEEENIKRMKSIYEVYLDRNGTLRTVKPVivd 349
XP_001647054 312 DFETSEDKMEGe----------------------dDEDNKVYAv---DPEDENVQRLKSIYQVYLDRNETVKQNQQQnvm 366
XP_003957497 302 VMNKSVRVQDVk----------------------yDDGNDDYAvqLSETEEENIKRMKSIYQVYLDRSGTMKQNAQlekd 359
P32900       313 THERNLRFGKDddnYelqdireae--hmndrssskSQDDDYYVslLSPNEEEDIKRMKSIYQVYLDRAKTMKKEEDKadn 390 Saccharomyces c...
EJS43383     320 PQIKGLRISTDn-dYelqdikepqysressgskgeDEDEDYYAshLSPNEEENIQRMKSIYQVYLDRAKTMKKAQDNadg 398
XP_056088245 308 SHRKSLQVGTNd-dYelqdikgpe--htddssgskDEGEECYVshLSPNEEEGIQRMRSIYQVYLDRSKTMKKEQDEldg 384
XP_003684010 421 -------lpKTSADGNLDDAEMPMPAQILNQNTNELGGNGVRESLRENGTdqeliSEVPLDqEDNLQQDVSTEHVAEENN 493
Q6CN21       345 ---------NPVPEGFQPVAELPKDASNIITESSNSNEPTNPSNIPENYQ-----AQPQHE-YYQNGYSLQPEAPQYPEE 409 Kluyveromyces l...
SCW00807     380 qen-afgeqSNFENGFAAAESLPVGATSQIDSAVKREQEKDLNSKQDLDApadmvTKANTL-HVPSQYDNSKARPASSIY 457
CEP63136     350 d----pvesDQYGNGFVASESLPDEARNAINHATGLQNNIESQQFEGERVf---------------------KNDQNALQ 404
XP_001647054 367 epkndilpdSKSAEIMKTDDHTGGPEANFDVVDNIELRDNSEIEHRKSQSinhltTGNEVE-SIGQGSSMHHRAVSSIYS 445
XP_003957497 360 ------adeINFEVENPSTSFSPTPSNGVNDENAVLVNEPSQEVFQSYSEdvtghTVEQVA-DTSYQDEGSQNESVESTN 432
P32900       391 a-----ndiSQEENRVDNIVQNPLPSIKINNNDNIDNNEVPEAKHLVKEAl----PLNNTN-LAEYGPEMAQSQKQYPVQ 460 Saccharomyces c...
EJS43383     399 v-----nalPKNETSMGYVDQNPLPSIQISNNNTI---EVPEVNYTAPKAa----TVGSIN-SSEYGSETAQKQDQYPVQ 465
XP_056088245 385 a-----naiSKSGAGFDSVNQNPLPSIQISDNDNI---EVPEAKYPGHEVf----VVKDTI-SDGDGRETAPNQEQYPIQ 451
XP_003684010 494 NSlpvnSEKL---HRVISSIy-----------------SEVP----LIDNFNENNANMASNNYNAGMNEQYNVnqqmdNG 549
Q6CN21       410 NY----GRGTqadGNTQSQD------------------TAAFenpnSNAPNQYSDPAPRVASSIYDTQSQYHN-----DH 462 Kluyveromyces l...
SCW00807     458 SEipriSQQPglqPVMPEQDy-----------------AQYPmqqqQMPEAQYAQQGVHPGHMQHQQGTQYGE-----GL 515
CEP63136     405 lp--qaGDEGtvgRRAVSSIy-----------------SELPtippQSAQSQYYNEQQYYPQNQYFHQGDYQ------NH 459
XP_001647054 446 ELpthaARQSvvrNDIQAAMsnepypsniqygnepqnyAQNNnnlqYVDQHQQLQQEPVYNHHPQ--AEYYNNsqpqlGV 523
XP_003957497 433 HLapvdNTATrksHRIASSIy-----------------SEAPnl-aLQEQRQQYQ-----NIQQQLSPQAYNN------- 482
P32900       461 DTltvnDTEAapsNRIASSIy-----------------SEAIqplnYQDQYQQQEQSPVYNGHTQYPGNGYSG-----NP 518 Saccharomyces c...
EJS43383     466 NTlavnGRGAvtsARIASSIy-----------------SEAIqplsYEGQYQQQEQSPVYGDNPQNLASQYNE-----DF 523
XP_056088245 452 DTlavnGTEAvasNRIASSIy-----------------SDAIpslnHQDEYQQQEQSSVYDSYPQYSASEYN------GH 508
XP_003684010 550 QYQNFTGTn----------YNNYDNYNNYGM-PQQPMPAQYNH-PQTHEEIAVLPTPTQLAYEQSSHSLTSFSGQSKrQl 617
Q6CN21       463 QQNQYYYN-----------HQYYGQNQYDGSfPTYHNQIQHNLpPPNMESIEELPRPSNLPFSGSSHSLTSFKSKTTlK- 530 Kluyveromyces l...
SCW00807     516 QYPPVAYQq----------NTYPPQSVPYSYpPQAYMPNQRYH-PQALENIQELPNPSNLPFSASSHSLTSFKKRGN--- 581
CEP63136     460 EYESY--------------HGASGPPNFY---PQMSAGLQQYHhPQTLENIQELPNPSNLPFSSSTGSLTSYRKNGK--- 519
XP_001647054 524 AEQGYYVQpnqayqasiysQQQQQQQPNMMY-QNPQ-EIQYKH-PQHLENISELPTPSRLAHSESVHSLTSFNGRTKpQ- 599
XP_003957497 483 MPQQYPYQl----------QGQMP--------PVPQIPPQHSH-PQTLESINELPAPAHLLQSSSTHSLTSFKQPSK--- 540
P32900       519 QQQGYT-------------AQFVQNPQWYGV-PTPQ-QQQHNH-PQTLETIGELPTPAYLAQSASSHSLTSFKRPNK-Q- 580 Saccharomyces c...
EJS43383     524 EQQGYP-------------MPVAQNQQWYGA-PTPK-QQQYNH-PQTLETIGELPTPAYLAQSTSSHSLTSFKRPNK-Q- 585
XP_056088245 509 IQQGHSIPv----------APIQQQQQWYGA-PAPQ-QQQYNH-PQTLETIGELPTPAYLAQSASSHSLTSFKGPNK-Q- 573
XP_003684010 618 NSNRLRTRAMNGTALNPMDHPDMFYKQG---SDQFSSYNQQLASHDGS-------GGTLHPHKLRESVVMINPHSLGAPK 687
Q6CN21       531 SPAAAAMTPQNNHNYNPIDHPELYFHQT---NGSDLGLSSDQASSNTTpsqinsaGSKVLPHHLRQSVVMTNPNELSQNN 607 Kluyveromyces l...
SCW00807     582 EIRLPNGTMLNGKSFSPIDHPELFYSQNmamEDSQSAFSQQTG------------AAQVLPHHLRQSVVMTNPMDLSQPT 649
CEP63136     520 SNLQLQASSYNGTTLNPIDHPELFYNQT---SGVNYAPSSLNQQETT--------KAQVLPHHLRQSVVMTNPDELSFPK 588
XP_001647054 600 QFPRLQAARLNGSALNPMDHPEMFYKQN---DGQYTMYQQNAQGFTSAeni----qnVTQPHQLRASIVMTNPTSLSLPA 672
XP_003957497 541 QQMQIQTARLNGTALNPVDHPEMFYTPN---NNSYGPIPNDNMSYTSNnti--gnGQAPLPYQMRQSIVMTNPADIQMNN 615
P32900       581 QLLQLQTARLNGTALNPVDHPEMFYSPT---NDAYYAPQQQGQYMKFNe-----nGAVPSPYQLRQSVVMTNPSDLTAKP 652 Saccharomyces c...
EJS43383     586 QLLQLQTARLNGTALNPVDHPEMFYSPT---NDAYYAPQQQGRFVKSNe-----nGAAPSPYQLRQSVVMTNPSDLIAKP 657
XP_056088245 574 QLLQLQTARLNGTALNPVDHPEMFYSPT---NDAYYAPQQQGQSMKYNe-----nGVVPSPYQLRQSVVMTNPSDLIAKP 645
XP_003684010 688 SFKPAGSFrSVSNNNSKANSLTTQNNP--YG---ANQVSNSYNSRVSGLIDHLDVSQPPSVGNILPHSSSNEDLRKQLGS 762
Q6CN21       608 LFKPAGSF-SRAVADSRSNSLMSNTNT--YQ---QQLQDTYIKSRVSGILDDTDVMHPPSMGTILPHSGSQEDLRKQLGS 681 Kluyveromyces l...
SCW00807     650 LFKPAGSFrNLSAANSRNNSMTSQHSV-------QQYRNQLAHQRVSGILDDHDTFQPPSVGGILPHSGSQEDLRRQLGA 722
CEP63136     589 LHKPAGSFrNISAANSRNNSMTSQHTT-------QQYQSQLAHQRVSGILDDHDAFPRPRVGGILPHNGSNDELRKQLGS 661
XP_001647054 673 SYKPAGSFrNINASNSRNNSLTVQNNP--Y-------QQQMGNSRVSGLLDYSDVVQPPGVSGIIPHSSSHDDLRKQLGT 743
XP_003957497 616 TYKPAGSLrNYNLPNSRNNSLTTTGNS--YY----KQLQKQADARVSGILEPSDVVQPPNAVGIIPHSGSNDDLRRQLGS 689
P32900       653 SYKPAGSFrSVSATNSRNNSLTTQNNI--YL---QQQQQQLYNSRVSGILEETDVVQPPSVGGILPHSGSQDDLRKQLGS 727 Saccharomyces c...
EJS43383     658 SYKPAGSFrSVSASNSRNNSLTTQNNAhqYL---QQQQQQQYNSRVSGLLEETDVVQPPSVGGILPHSGSQDDLRRQLGS 734
XP_056088245 646 TYKPAGSFrSVSATNSRNNSLTAQNNT--YFqqqQQQQQQQYNSRVSGILEETDVVQPPSVGGILPHSGSQDDLRRQLGS 723
XP_003684010 763 SQNY 766
Q6CN21       682 SHNY 685 Kluyveromyces lactis
SCW00807     723 SENY 726
CEP63136     662 SDNY 665
XP_001647054 744 SNNY 747
XP_003957497 690 SHDY 693
P32900       728 SHNY 731 Saccharomyces cerevisiae S288C
EJS43383     735 SHNY 738
XP_056088245 724 SHNY 727
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