Conserved Protein Domain Family
Nse5

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pfam08691: Nse5 
DNA repair proteins Nse5 and Nse6
Nse5 and Nse6 are non essential nuclear proteins that are critical for chromosome segregation in fission yeast. Nse5 forms a dimer with Nse6 and facilitates DNA repair as part of the Smc5-Smc6 holocomplex.
Statistics
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PSSM-Id: 370066
View PSSM: pfam08691
Aligned: 15 rows
Threshold Bit Score: 184.315
Threshold Setting Gi: 74607884
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDO18914       1 MNYAEPCSTSNEFTNKNDikslPY-----YFVHLTDKHLSNFETLNAMALIGNYADLLFFIESY-------ETSDTFVVP 68  Vanderwaltozyma...
XP_002555231   1 MSILSHGSEKVGVP---------------YNVGLTTESLSVFEVLNSLCVVENYDQLLYYLEAR---------RSALAVP 56  Lachancea therm...
Q756F5         1 MNASVGDHDMPSPSEAAV----PH-----YFVELNEHYLKDFEQFSSLCSLDEYEQLLYLLEEK-------FVAGRVAIP 64  Eremothecium go...
Q6CWU9         1 MASQSH-KYDLGRNELNK----PD-----YYVELTEKHLSDFEIWNSLCSNESYDMLLYLCEQY-------LNMGRFPVI 63  Kluyveromyces l...
XP_002171507   1 MASQHFSDAEIPDSQSSSgsstPS-----SPTSSPSSASSTSEALPAVSALLPTASRVRTRSARlrakrrcLPTRSYVWS 75  Schizosaccharom...
O13688         1 MNASNNISKFPDLDNSSK----------------LIDHILDSDDSEELDELPDISSLVPSARAQsrkqylkNDSSNSSTY 64  Schizosaccharom...
O94668         1 MNSALK-----------------------AIIELCIEEDLLPKSLDVLEYLLSTTSIPIP-------------------- 37  Schizosaccharom...
Q6FWW8         1 METVFDSENDE------------------PLVELSDVDDFEFEDGD---------------------------------- 28  [Candida] glabrata
EDO15214       1 MSDNSSSIHDSQDSDESV-----------TTIYNSNNHKIKDEKSTSKYPEVSDEEIDSDIDLYlidd------------ 57  Vanderwaltozyma...
EDN63007       1 MGSVNSSPNEEFETVPDSqisgFDsplipTSVGSYFRDDDDDEKVHPNFTSDPENDSLNSDEEFsslensdLNLSGAKAE 80  Saccharomyces c...
EDO18914      69 P----YDIIILLLTLVTVSKYYKEATVRKNDYYVLTG------KQLNKRSIAILKNYIEILNEFDCGKYDRYSLELLRCQ 138 Vanderwaltozyma...
XP_002555231  57 P----ADVLIVMMTLSVIPDFGAATLEAEMDPYNVGR------ASLATRSIKLLRHFTDILLSEHAEEENHYSLALLRSQ 126 Lachancea therm...
Q756F5        65 P----GDVIVVLLTLATASSHYKADFVRANDPYNVGR------TDIAHRSMRLLSRLVDAVEEFDDRRYMRFELELLRCQ 134 Eremothecium go...
Q6CWU9        64 P----SEVIAVLFTLASIGDHNKGSLIKKADPFDTGR------ELLTRRSMKLLETLLDILQTFDTDLYEIYDLELLRCQ 133 Kluyveromyces l...
XP_002171507  76 -----LDRLSKSAVKDATLSHRRKNVIQKLTHYGSAQsqgtrvASVEKAILKNLGMNESVLSSIKAEQDTQDAASEFHYS 150 Schizosaccharom...
O13688        65 Rw--nIDLLSSTATIDDSVAKRRKLAVQNLLQYDSTQ----------------TFQTGDEIDELIGKSVGSNVLNVLRSN 126 Schizosaccharom...
O94668        38 -----ACYIRMCITLLVHPEYPTSSNIQE-------ScnwilqQVVENRSKINFDAWSFENDLSDNDMPKENYLKIFSNQ 105 Schizosaccharom...
Q6FWW8        29 -----DPILKKMKL----DVKPESSSDSEg------------eVVLQETDVHPYMDFLQKLNKIQAGEVGEKRDIKRDKS 87  [Candida] glabrata
EDO15214      58 --sedDEILLKMSSFNGSSKKPAVIKNENgyi---------niKSFDLGDLYN-EKVTKNLNSIESAEDKINNEKKKFVS 125 Vanderwaltozyma...
EDN63007      81 SgddfDPILKRTIISK--RKAPSNNEDEEIVKTPRKLvnyvplKIFNLGDSFD-DTITTTVAKLQDLKKEILDSPRSNKS 157 Saccharomyces c...
EDO18914     139 FFLAIELIfn---kEKRTDIRNRFKRRRAEVEFEieyltssvdenNDDDTIGFQNPYNSYIPFLDRNKTVLGNKLFNIVL 215 Vanderwaltozyma...
XP_002555231 127 FFIMLDQLslrgitSTRVRERDFTKRRKTNSGVLleaspsifrddQSPPLLSFKNPYPSYVSCLEHRPEVLKNMPITSKL 206 Lachancea therm...
Q756F5       135 LFLFLDSIvp---kRPEVTIAKRVRTHGKNQPTDipfapdemplcVD----SLRSASYKYVSVLETKKAVFQNVLLTHVL 207 Eremothecium go...
Q6CWU9       134 FFYFIDSIrpengrALVLDPLNAQSSRATRRSFKlss-----rsaEGGSLLSVEPLYGSYINLIGDDTSVFKTTMVHSAL 208 Kluyveromyces l...
XP_002171507 151 YVGVVATG------EKSLWSSPKEEGRESSPVDVsslspsdvadfVCSGLLSFEDVVSQIF---------------TRFF 209 Schizosaccharom...
O13688       127 PIYDDDL-------RYEYCSNSKARVPDWNTLKAeclkdndlefnEGIIPTTFGDLLSAKLVPLDIALSICS---LQFFR 196 Schizosaccharom...
O94668       106 CLFTQDVDyw---dLIAYMSSRPPDLERWMSLMDiwlrileidaeENGSALMKKYMGEDLCELQDAIRICFSCFTLPQQT 182 Schizosaccharom...
Q6FWW8        88 IVELQHEE------LVKQLKSAGTFTSVPDRLIDhissevlsdkfRDWHFITQECRDIDNT------------------- 142 [Candida] glabrata
EDO15214     126 KTFTKSN-------ELMAKLSKNFTNSQLSYYIDtiikdanpdkyLDWHFIEEDTTIDDISPILSFETAYYNCHDFNRIR 198 Vanderwaltozyma...
EDN63007     158 IVITSNTVa-----KSELQKSIKFSGSIPEIYLDvvtketisdkyKDWHFISKNCHYEQLMDLEMKDTAYSFLFGSSRSQ 232 Saccharomyces c...
EDO18914     216 NKRDSFINLLIWTLSNSL------EEDTALYLSS--QEIWMPILQMILDIYLL----RHDYYIQNELTNKGNSHfFSREl 283 Vanderwaltozyma...
XP_002555231 207 SQEGEFWNCVGWALYASL-------SDDSHIYER--SKVWFAVLSVLFDAFEM----RNKYSIDSETDPTANNAaRLSFi 273 Lachancea therm...
Q756F5       208 SQNGGFWNCVAWTLSTMI-------DKDAVKNYC--GETWFPIVTFLFRLYEL----RHAYYMQYEMTQGISSAaYTKEl 274 Eremothecium go...
Q6CWU9       209 SQEGSFWNGFSWALSTFMigheneDQKTDWDYEL--AKAWLSVFKLIFIIYEL----RQDYYIDSKTETIEKS------- 275 Kluyveromyces l...
XP_002171507 210 ENKGANCEEWAVCLQRCLdklsssSTKPILLPYI--SS----VLQAVVDMLGIdvgkRHTPVAHDSVRPPASTApSNYSv 283 Schizosaccharom...
O13688       197 SLGDTTCSEWIANLEKIFysykssSNNLNQIVRF--------IFETTADMIGIdlakRQVPIQLERTSASENLKsNLKI- 267 Schizosaccharom...
O94668       183 MES---------PFATSMskapakTESRGSN-----------SFEGTSRLANLg-------------------------- 216 Schizosaccharom...
Q6FWW8       143 ------------TLSSMLdafgvgNSADLLNLKIi-ASEYTKKYDSLSTIYPVgymlEELVDYYRRTLPRAETPlE---- 205 [Candida] glabrata
EDO15214     199 HEILKSYP----NLNYILptfgisKEKLNSINDGyfCISDYYNYDNLCTILPTdsmkSIIIYYIDEPN------------ 262 Vanderwaltozyma...
EDN63007     233 GKVPEFVHLKCPSITNLLvlfgvnQEKCNSLKINy-EKKENSRYDNLCTIFPVnkmlKFLMYFYSDDDNDDVREf----- 306 Saccharomyces c...
EDO18914     284 s-rSPIGTLLRSIGEVDFIERFCESV--FINCSDRNDILSYRTVMQRIYQN--ENVISNAFLPRVKYSNDYKMLKSMSIR 358 Vanderwaltozyma...
XP_002555231 274 e-rSPLVALFRSLNSQGLIQAFCDIL--FLGCSYEL---AGKLRVHCVYPK--ELMQVDTYVPKLLARTSCKFTQSMSFR 345 Lachancea therm...
Q756F5       275 a-dSPLVLLFKSLGSNNVHITLCDYL--FVNCGKNV----GRGEARPVYHS--ELKLSATYVPFCKPSTEWKLFKSMQLR 345 Eremothecium go...
Q6CWU9       276 ----PIFRLLEAVDKKNQLKGLVQYL--FVGCVECE-------ILYPVSPSlnDPSTSNASFNQFHEDKDYRAAFSMDVR 342 Kluyveromyces l...
XP_002171507 284 aatVKLLTLLYPLCELPLQKDIVADL--CRIALDTAVSDDVRLVIMDAFASilKVPRATHSRTRSRSSDDAWQILYETTT 361 Schizosaccharom...
O13688       268 ----KVINFLKCCGTLYRFSDDTVRFemIQDACRILIDNQVGSFCKWQFSQfmELPISLNPDFLISNIHKVSES------ 337 Schizosaccharom...
O94668       217 ---aKLLCLIWAMLPKGRF--FVVHLtdAFHFLSKLDERFSKLNAKQQDLFfgNLGASNLRYCLSQYI------------ 279 Schizosaccharom...
Q6FWW8       206 ----YCHAFFLFVLDIKIYDSHECDTswCEEVLDILTQRFRQEEIFDVYLKvvELNDYYMHYRVTKLIPRMKSY------ 275 [Candida] glabrata
EDO15214     263 ----FVKFFLCFILDKKIYESNDCDSkwCEEIVSALD-----VDVIEEYLKliNLDDYYMHYRLTKLLPSFKNK------ 327 Vanderwaltozyma...
EDN63007     307 ----FLKAFICLILDRKVFNAMESDHrlCFKVLELFNE----AHFINSYFEivDKNDFFLHYRLLQIFPHLQSA------ 372 Saccharomyces c...
EDO18914     359 RKMIGLCFRLLQDLDDDERLELPKMSTNTLGDSIIRCVINFDNIKQFKMFFytemiskelfflpILAEDCILKLSENYLE 438 Vanderwaltozyma...
XP_002555231 346 HRLLSLFLTMLRSIPEGVEFSKPCLSEAGFVRHLGKVLSSFEDTSQLKQFFsvtnpyefldympLFAQAAANESLKAFDA 425 Lachancea therm...
Q756F5       346 RRILSCYFKVLADIPKDHRIK--PFSEDQSIKYMVRTLLELETVEMFQAFFftddlkitmhylpLLAEHIIVVLLEDCGK 423 Eremothecium go...
Q6CWU9       343 KDTLCVFVRFLDRYER--HLQSYPFTLDALYGTIVDALYSDLKISSFKQFFlscdvekdrnlitTLVEKLLNKAFSNVEP 420 Kluyveromyces l...
XP_002171507 362 NAQAWVTLLMLLPNRKGIIRNRQKLALSWFLSKPLQSINNNNDNASLFAEV-------------CEAIEALPNKTAEDFV 428 Schizosaccharom...
O13688       338 ---PRVWVTILSSLSRSCQKFRKKIAFTLFVGKQSKN--DDSDFSSLCQRL-----------------DEISASCNNDYT 395 Schizosaccharom...
O94668       280 ---------LMKGIGIGINIRHTRCEFTKQLTQLLPTSLPKNKIRQKLHLR----------------------------- 321 Schizosaccharom...
Q6FWW8       276 ---------ILAKLFGTVD--------TVTIVNEFNTLLDDKRYKELLYFL----------------------------- 309 [Candida] glabrata
EDO15214     328 ---------LVDGIFGDNTLA------LNRIIDEFNTIFDDKEYRKLLYFS----------------------------- 363 Vanderwaltozyma...
EDN63007     373 ---------LLRRRFSEKQGRTETI--QQNIIKEFNEFFDCKNYKNLLYFI----------------------------- 412 Saccharomyces c...
EDO18914     439 NNREt-lDLCSNFNNS-KAF--FQ-ILVELINDgyfyipelkcndndaydksnnkekndenNKIDAKIKKSLYKKYITIM 513 Vanderwaltozyma...
XP_002555231 426 NYTL---SLVEKLANN-DLV--IE-ELGNVFEAg--------------------------fPPLDENYDSRPEQFYSSIE 472 Lachancea therm...
Q756F5       424 AIES---TLVTNLGNL-DVV--IE-NIEEYLEM----------------------------RPVDCSNAIGLHKTVFYI- 467 Eremothecium go...
Q6CWU9       421 RRTFnivNKMSNFEEV------TS-ELMKLLRA------------------------------IDRSAAFNRSRISKRRI 463 Kluyveromyces l...
XP_002171507 429 RVRYsisALFFAFHGElAPQ--PD-EVLRLLALl---------------------------RKLDHSIHGTTTDSLMLLR 478 Schizosaccharom...
O13688       396 TLLYqirTFGYAVDEKhFKT--NE-RLECLLEKl---------------------------RKIDLTISGSTDHLLLSRC 445 Schizosaccharom...
O94668       322 -------AWVSFLGSAlRES--DR-NFDKELFY----------------------------TTLKQLYTMYQQTELVGID 363 Schizosaccharom...
Q6FWW8       310 ---------LLVLGTRyVPRgkN--ETIKYFIS----------------------------CVTDVYDDSQ-SNPEISI- 348 [Candida] glabrata
EDO15214     364 ---------IFIFGSDlVPYskESlPVIDYIFN----------------------------CIRDVSDMTNVADIELLL- 405 Vanderwaltozyma...
EDN63007     413 ---------LTMYGSKfIPFgpKC-QVTEYFKD----------------------------CILDISNETT-NDVEISI- 452 Saccharomyces c...
EDO18914     514 KADICLIVLLRf-FIYENSNMNEIKALSSFnn---------------------------------------------fLA 547 Vanderwaltozyma...
XP_002555231 473 KCDIFLLVILRy-WEYIHGAQLKMTRMRCA------------------------------------------------IR 503 Lachancea therm...
Q756F5       468 --DTCTLVLIKy-AILLHGTDVLLTGGLDMa-----------------------------------------------LK 497 Eremothecium go...
Q6CWU9       464 QMDFCIIILTR--LIITTHPQGNFEELLRV------------------------------------------------LT 493 Kluyveromyces l...
XP_002171507 479 CEAKDVVQRLYlyVYYEHCNAYQVLEQAADmnmnvsaadlqddiiaptakseavtagdikvavkdnleaeteeepkseVK 558 Schizosaccharom...
O13688       446 EVKDCIHRLFMvlYYLNTNSAPELERI---------------------------------------------------IE 474 Schizosaccharom...
O94668       364 RPMAI-------------------------------------------------------------------------LK 370 Schizosaccharom...
Q6FWW8       349 ------------------------------------------------------------------------------IK 350 [Candida] glabrata
EDO15214     406 ------------------------------------------------------------------------------LK 407 Vanderwaltozyma...
EDN63007     453 ------------------------------------------------------------------------------LK 454 Saccharomyces c...
EDO18914     548 RVKK 551 Vanderwaltozyma polyspora DSM 70294
XP_002555231 504 ALSV 507 Lachancea thermotolerans CBS 6340
Q756F5       498 RFFK 501 Eremothecium gossypii
Q6CWU9       494 TFAK 497 Kluyveromyces lactis
XP_002171507 559 AEAK 562 Schizosaccharomyces japonicus yFS275
O13688       475 SDLP 478 Schizosaccharomyces pombe 972h-
O94668       371 DMLV 374 Schizosaccharomyces pombe 972h-
Q6FWW8       351 NYLL 354 [Candida] glabrata
EDO15214     408 SILT 411 Vanderwaltozyma polyspora DSM 70294
EDN63007     455 GILN 458 Saccharomyces cerevisiae YJM789
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