Conserved Protein Domain Family
ASD2

?
pfam08687: ASD2 (This model is not part of the current CDD release)
Apx/Shroom domain ASD2
This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.
Statistics
?
PSSM-Id: 518434
Aligned: 40 rows
Threshold Bit Score: 225.24
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EFN86985      340 DLASQLSPNDK-LLPILVPApEHKKPTDYVSGLFRVEATLQPRPRRRLSLeestascgedadadekkhetipsapvtpLs 418 
XP_001987825  417 ELLRQLPPSDK-LIEILTPK-SCKPTTQYVNNLYNPNVPLRPAKRDVGTS------------------------------ 464 
EDX07069      152 ELVKLLPPGDK-IADILTPK-ICKPTSQYVSNLYNPDVPLRLAKRDVGTS------------------------------ 199 
XP_002016051 1396 ELLQLLAPNDK-LVDILTPK-SCRPTSHYVSNLYNPNVPLRLTKRDVGTS------------------------------ 1443
XP_023030547 1408 ELLKLLQPSDK-LVEILTPK-SCKPTHEYVSNLYNPDVPLRQAKRDVGTS------------------------------ 1455
XP_005335822  547 ELVQELARLDPsLSDTLTSQpCPEPPLGLLDGLIPLAEVWAAMKPGCGEA------------------------------ 596 
NP_001095764  535 ELVQELARLDPsQSDTFTSYpSPEPALGLLDGLIPLAEVWAAMRPACREA----------------------------G- 585 
EHB00064      345 ELVQELARLDPsLSDTLASEpSPEPPPGLLDGLIPLTEAQATVWPAFREP----------------------------G- 395 
XP_009447907  544 ELVQELARLDPsLCDPLASQpSPEPPLGLLDGLIPLAEVRAAMWPACGEA----------------------------G- 594 
XP_012664677  529 ELVQELARLNPsLSDTLAFQpSPEPPLGLLDGLIPLADVWAAMRPACGEA----------------------------G- 579 
EFN86985      419 AD---PTSPLSPTSAYFTTSEGKARFLT--RYSRDvtvegLTRQEDApAIVPTNs---LDLRQKKEELMMRLDRKLVVLR 490 
XP_001987825  465 -----------------TLMRMKAAGTTtlIAKAElql-tsVELHLTddt------gtNLIKQKLDELIKQLNQKIVALK 520 
EDX07069      200 -----------------TLMRMKSITSSaeIrv------vsVELQLAe----PSeeptNLIKQKMDELIKHLNQKIVSLK 252 
XP_002016051 1444 -----------------TLMRMKAAAAPteTTkv-----vsVELQLGd----ASgegaNVIKQKLDELIKRLKQKIGALK 1497
XP_023030547 1456 -----------------TLMRMKSDSSEasTPEISgkminIVQLHLTd----PSgegtNLIKQKMDELLRRLNQKIGSLK 1514
XP_005335822  597 GEegpGTSEPGSYQFNFTQLLPTSQEMT--RPENSpscpmPDCPNAQ-T---SN----NSVQAKKVELAGLLQEMLQDLH 666 
NP_001095764  586 -EeaaGNSEPGSYLLNSTQHLPTSQEET--RPENLtthvaPDQPCDQdVPKPNN-----SIQAKKAELADLLQKMLRDLQ 657 
EHB00064      396 -EevaSTSEPGSCLFSFTQLLPASQ-ET--RPENAtllpvPNQPCGQgLPAQNV-----SIQVKKVELAGLLQKMLQDLH 466 
XP_009447907  595 -EeaaSTFEPGSYQFSFTQLLPAPQEET--RLENPathpvLDQPCGQgLPAPNN-----SIQGKKVELAARLQKMLQDLH 666 
XP_012664677  580 -EeaaGTSQPGSYQFSFTQFPPTSQEEE--ILKNSathpvPDQPHGQgFPEPNN-----SIQAKKVELASLLQKMLWGLH 651 
EFN86985      491 AEQEAVREEGEVNEALGARVSARVSAVARPPEASKYRLHVEEVGKITSLLLGLSGRLARAENALYGM-PADHA--ERKIL 567 
XP_001987825  521 REQETIVEECFTNDKLGSDLLANLTEKVRPSEASKFRTYIDDVGHITSLLLSLSERLAQTESSLEARaSSSQQ--EKNTL 598 
EDX07069      253 REQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLE----TRQQ--EKGAL 326 
XP_002016051 1498 HEQQTIGEECSMNDKLGQDLFAKLAESVRPSQASKFRTYIDDVGHITSLLLSLSERLAHTECSLE----SRQQ--DKSVL 1571
XP_023030547 1515 REQQTIGEESSMNDKLGQELFAQLAEKVRPSEASKFRTYIDDVGHITSLLLSLSERLGQTESSLE----SRPQ--DKSIL 1588
XP_005335822  667 IQEERLQDAAQEWTRRRLALESAVGQACAPRELERFSRFLADLERVLGLLLLLGSRLARVHHALARM-GSDGDpdERDSL 745 
NP_001095764  658 AEQKQLQGAAQAWARRGAALEAAVGQACAPHELERFSRFMADLERVLGLLLLLGSRLARVHRALARV-GADSDpeEQASL 736 
EHB00064      467 ARQEQLQGVAQAWARRRAALEAAVAQACAPRELERVSRFMADLERVLGLLLLLGSRLARVHRALARV-GSDGDpeERASL 545 
XP_009447907  667 TEQERLQGEAQAWARRQAALEAAVRQACAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARA-ASDSDpdEQASL 745 
XP_012664677  652 SEQERLQEAAQTLARSQAALEVVVNQACEPRELERFSRFMADLERVLGLLLLLGSRLARVRRALAWA-GADGDpdERASL 730 
EFN86985      568 ESKRDKLMDQLEEAKILKSNIDKRSVNVSAILAKYLNQEEFADYQHFINMKAKLIMDGREIQDKVKLGEEQLAALKEAI 646 
XP_001987825  599 QAKCERLYEQLEEAQRLKADIDRRGSSIAKLFGKHLSADMCADYDYFINMKAKLIADARDLADRIKGSEEQLGALSDAL 677 
EDX07069      327 ESKRDLLYEQLEEAQRLKSDIERRGVSIAGLLGKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 405 
XP_002016051 1572 ESKRTRLYEQLEEAQRLKSDIDRRGTSIAGLLGKHLSADLCADYDYFINMKVKLIADARDLADRIKGGEEQLGALTDAL 1650
XP_023030547 1589 ESKRERLYEQLEEAQRLKSDIDRRGTTIASLLGKHLTADMCADYDYFINMKAKLIADARDLAERIKSSEEQLTTLNDAL 1667
XP_005335822  746 LQRLGLLQRQQEDAKELKEHVARRERALREVLARALSAEELCSYSELLVGKATLLTQQRCLEEHVRLFQNQLDTLGSNL 824 
NP_001095764  737 LQRLGLLQRQEKDAKELKQHVARRERALRELLARALPAEELSAYRTLLAGKAAVLAQQRSLDERVRLIQDQLDAVRNDL 815 
EHB00064      546 LQRLGLLRRQQEDARELKEHVSRRERALREVLARALPAEEVRAYCTLLADKAAVLAQQRSLDERVRLLQDQLDAVRSDL 624 
XP_009447907  746 LQRLRLLQRQEEDAKELKEHVARRERAVREVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDL 824 
XP_012664677  731 LRRLELLQRQQEDAKELKEHVARRERALREVLARALPVEELRAYSALLAGKAAVLAQQRSLDERVRFLQDQLDVVSSDL 809 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap