3KDG,3NCV


Conserved Protein Domain Family
MutL_C
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pfam08676: MutL_C (This model is not part of the current CDD release)
MutL C terminal dimerization domain
MutL and MutS are key components of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerization.
Links
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Statistics
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PSSM-Id: 518425
Aligned: 80 rows
Threshold Bit Score: 88.0441
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KDG_A  12 IGQMHGTYILAQNENGLYIIDQHAAQERIKYEYF-REK--VGEvepEVQEMIVPLTFHYSTNEALIIEQHKQELESVgVF 88  Bacillus subtilis
Q7MYT9 455 LSIYSPCYALIESPLGLGLLSLPVAERWLRQAQL-APT--EQGl--KSQPLLIPLKLSLSKEEAGALNRYSDLLGSFgIE 529 Photorhabdus laumondi...
Q8ZIW4 459 LTVFPPCYALIEYQGGVALLSLAVAERWLKQAQL-SPP--EEGl--RPQPLLIPLKITLDKNEIAACQNHEKLLITMgIE 533 Yersinia pestis
Q87L05 487 LVVVDEQFVLMSSDSGVALVSLPRSEFYRTKGQLtPSE--GAL---KAQPLLVPLSMKLDTDLVRLAQDYQQDFAQLgIQ 561 Vibrio parahaemolytic...
Q9KV13 474 IQVVAGQYLLMSSPQGCVLISLYQAQQLKLRGLLnAQH--GAL---KAQPLLVPLALKLNESEWQVAQRHSSALLQLgIE 548 Vibrio cholerae O1 bi...
Q6LM28 535 LSIVAERYLLVSRHDGIHVLSLDHAQRLHHKGQL-RLA--ATEg-lKPQPLLIPHSVPVEPDLITCAEQHALLLKQLgIN 610 Photobacterium profundum
Q5E2C6 483 LSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQL-SSVnvEPL---KPQPLLIPLSVGIDESICNNLSNYASLLKSLgID 558 Aliivibrio fischeri E...
P57886 449 LALVENKALLLQQQQQFYLLSLQQLQRLKIELSL-Q----RDPv--LQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIgFE 521 Pasteurella multocida...
P44494 462 LSLIENRALLLQQNQDFFLLSLEKLQRLQWQLAL-K----QIQi--EQQALLIPIVFRLTESQFQAWQQYSDDFKKIgFE 534 Haemophilus influenza...
A6VN10 471 VALVNNQALLLQRDTAFYLLPLNKLQKMRLELLL-T----LPNt--PQQMLLIPVVFRLSDKQQAQWRQQKIWFEQSgFE 543 Actinobacillus succin...

3KDG_A  89 LES-FGSNSYIVRCHPAWFPKGeeAELIEEIIQQVLDSKNid--ikKLREEAAIMMSCKGSIKAN---RHL 153 Bacillus subtilis
Q7MYT9 530 AS--VSHGKATLCAVSLPLRQQnlPKLIPELLGYLAQQPs------ASAEQVVTWLARHIGSEY----ETW 588 Photorhabdus laumondii subsp. ...
Q8ZIW4 534 LS--VEQGRATLRAVSLPLRQQnlQKLIPELLGYLSQHEe------ISPDTLATWLARHLGSEHEvwnVSQ 596 Yersinia pestis
Q87L05 562 LKA-RNDKALMVMGVPAPLRQQnlQNLVPDLLSYAQTWMKgekastQMLPALIDWLAVQVTTVK----SHY 627 Vibrio parahaemolyticus RIMD 2...
Q9KV13 549 LKS-RTNHSIMVMAVPQPLRQQnlQQLLPDLLSYAASCSEsq---aLSHQALADWLTQRIVVEK----RDY 611 Vibrio cholerae O1 biovar El T...
Q6LM28 611 LKA-KGKSGLIILSVCLPLRQQnlQQLIPNLLTYLLSIAEdp--daQGWDKLWDWLATQCVMPV----DTF 674 Photobacterium profundum
Q5E2C6 559 LKV-KNRTNIIVMAVCQPIRQQnlQQLIPNLLRYLEQIN-------PSLEQVIKWLSHQIQHDE----VSY 617 Aliivibrio fischeri ES114
P57886 522 FHEnLGQQRITLNRVPSCLRQQnlQKCIIVLLSQ-------------PLDTFSHFLTTLCDVIELe--QIT 577 Pasteurella multocida subsp. m...
P44494 535 FIEnQAQLRLTLNKVPSALRTQnlQKCVMAMLTR-------------D-ENSSSFLTALCAQLEC---KTF 588 Haemophilus influenzae Rd KW20
A6VN10 544 FIEnPVQHRITLNAVPQCLRHQnlQKIVIALLNR-------------SLQKTEKFLTALLDLVELp--DCQ 599 Actinobacillus succinogenes 130Z
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