Conserved Protein Domain Family
DASH_Spc34

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pfam08657: DASH_Spc34 
DASH complex subunit Spc34
The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules.
Statistics
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PSSM-Id: 400819
View PSSM: pfam08657
Aligned: 23 rows
Threshold Bit Score: 137.203
Threshold Setting Gi: 240131173
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FLI2         5 MNSCLEEINGCLDSITSLYFKPPGIFHNAMIRiskdgkETHTLNDKIKNLIKGCDPKEETTLFQLDP------------- 71  [Candida] glabr...
EEH03592       4 LESHLEQISLSATAIADLPFPPPKIFANAMLG-----------PHDITTLIRDTEPHER-ALFSIDP------------- 58  Histoplasma cap...
XP_006965141   6 LSAHLEQIQACCQGIDSLPFPPPRIFTNAMLS-----------KHDITSLIRDTEAHER-ALFSVPPpppaa-------- 65  Trichoderma ree...
ERT02684       6 V--HLDQISVSCQGIRSLPFPPPKVFTNALLY-----------NDDITSLIRDTEAHER-ALFSVPAplp---------- 61  Sporothrix sche...
EJT75418       6 LAAHLEQIAISCQGIDSLPFPPPRIFTNALLS-----------THDITSLIRDTEAHER-ALFSVPPpppq--------- 64  Gaeumannomyces ...
ABN65516       4 LNYFLDRTEQSIRSIQSQTFASPGIFTNAVVK-----------KPNIMALLKDPTSDER-SLYKISKprmkttkastei- 70  Scheffersomyces...
Q6BNC4         4 LSYFLDRTKQLCESILSLKFQSPGIFTNSFIK-----------EPSITSLLKDAEEHEQ-ALYKINKprgfnnlskplip 71  Debaryomyces ha...
XP_004194628   4 LSYFLDRTKQSCESLESLKFSSPGIFTNSFIK-----------EPSITKLLKDAAGHEQ-ALYRINKpsalskgsntsih 71  Pichia farinosa...
EDK38701       4 LDYFLERTRGSCESLNSLQFKRTGIFTNAFNR-----------GAPITRLLKDSAPEEY-ALYKIHRknpvfsssnd--- 68  Meyerozyma guil...
XP_004182107   5 LDLCLQELQSSSESLNNIHFKPPGIFHNALTRlls-pnTTKQEAIPFTKVIRDRDPEEEDNLFSYNK------------- 70  Tetrapisispora ...
Q6FLI2        72 --------------VTKSLRRKDGRQALFDYLDKRDLNMKRNRRLGHKD--------EKPVIHVPNEFYIREHDEELLRD 129 [Candida] glabr...
EEH03592      59 -----------------------------------------------------------SANSQPRV------------- 66  Histoplasma cap...
XP_006965141  66 -----------------------------------------------------tataKKPPSSRPTE------------- 79  Trichoderma ree...
ERT02684      62 -------------------------------------------------------aaKTTPAEAPST------------- 73  Sporothrix sche...
EJT75418      65 -----------------------------------------------------pqqpQKPANPEPAD------------- 78  Gaeumannomyces ...
ABN65516      71 --rrrkraaladefMEIKPERVDGKSTYVDRSFYGVDNAAETNeeke-------evvKRTVVQLPE-------------- 127 Scheffersomyces...
Q6BNC4        72 nnkndkekesirmqLEMRPERIDGKSCYVDYSFNDFTNVNMNNNKQAPPse----qaKRTAVRIPE-------------- 133 Debaryomyces ha...
XP_004194628  72 esrrnsskenipfsLESRPERVDGKTYFIDNSFNEFTNYHT------PEgnqthinrKRTAVSLP--------------- 130 Pichia farinosa...
EDK38701      69 ----vndddseaalMEVLPERKDGKSLFVDKSFNEYTQIKTTNEG------------KRTAVRVPD-------------- 118 Meyerozyma guil...
XP_004182107  71 --------------KRRIPARTDGEKGILDYLRDREITFKGNP----TE--------NIPLVHVPNEIYLRQNDARWRKE 124 Tetrapisispora ...
Q6FLI2       130 SQRTKrfka-----aghGNDIDSNNTnntttalitelfnDDVGLMATMRKKFKENDEIKNLLMALQKGSVI--------- 195 [Candida] glabr...
EEH03592      67 ----------------------------------------------TSASSANSQRRTTRRVTTAASGSSFpdlvlplph 100 Histoplasma cap...
XP_006965141  80 -----------------------------------------------DEKAESKPRNRRQTVFNVASGEVT--------- 103 Trichoderma ree...
ERT02684      74 ---------------------------------------AVSGAGDSGAGVAASSSKRRQTVFNVAAGEVT--------- 105 Sporothrix sche...
EJT75418      79 ----------------------------------------------ADDLAGNTGKKRRQTVFNVAAGEVT--------- 103 Gaeumannomyces ...
ABN65516     128 --------------------------------------------------------LSYDFPAINKNVTHS--------- 142 Scheffersomyces...
Q6BNC4       134 -------------------------------------------------------------IVKESIENVH--------- 143 Debaryomyces ha...
XP_004194628 131 --------------------------------------------------------------LVVKDTSKT--------- 139 Pichia farinosa...
EDK38701     119 ---------------------------------------------------------------------VS--------- 120 Meyerozyma guil...
XP_004182107 125 NKLSHswlyqpndsqhsQTNFTTQGSigmt------kshTDRGVLERLFTKYSNDTQMIQLLKALQSGSIT--------- 189 Tetrapisispora ...
Q6FLI2       196 LDEKEgis-----tnNR-RRTLFVE-----------------------DFSTESILKLLDAVLEMFPTEEYKK------- 239 [Candida] glabr...
EEH03592     101 EGGDSmasriyaakhNK-SQSAVTQvlggdmvd--------eikkprgEVDVKVLLRGAEMLCNVYPIPGAQE------- 164 Histoplasma cap...
XP_006965141 104 TGPTTtssrggagggAPhRRTAVAAvlggemheql----rrgetdrkgDLDVEVLLRGAEKLCGVYELPGARE------- 172 Trichoderma ree...
ERT02684     106 TGPPSarp-----saAPrRQTAVAAvlggdlhaqig-rrtggggggggDVDVNILLKGAEKLCTVYALPGALE------- 172 Sporothrix sche...
EJT75418     104 TGPPPgtggrsaggsR--RNTAVAAvlggdlhsqitragrggprgadgEVDIEVLLRGAEKLCQVYPLPGALD------- 174 Gaeumannomyces ...
ABN65516     143 NVPSSptksgiptsnAY-FALSSPE-----------------------EADPSKLIDQVLTLLQKYPTLIVNQegi---- 194 Scheffersomyces...
Q6BNC4       144 ENNDVpsspekiinvNL-IPESIIL-----------------------SDNINDICETILGLIRRYPNLIQENktapd-a 198 Debaryomyces ha...
XP_004194628 140 AEGDTpgsvdhtshnKL-IPQEILQ-----------------------STKVDELCEYLTDLITKYPNLIEDEtesdaqg 195 Pichia farinosa...
EDK38701     121 SYPETgsepehnsqtERwIFSACGE-----------------------DAPVDRLCSMVVELVEKYPHLDENDvm----- 172 Meyerozyma guil...
XP_004182107 190 VGTTDnisp---sknNR-RKTMFVE-----------------------DFQTESLFLVLEEVTSQFPSEENRV------- 235 Tetrapisispora ...
Q6FLI2       240 ----AAEQYHDVFQELNEESEKLLAEIQLQKDEIEGRLKIESSKDs-------------------------TTGVQKLIE 290 [Candida] glabr...
EEH03592     165 ----QISTLRHRHEHLSASIAHLESRIAEQAAQLQRMNRSQDYSSdydpaelets-------tevlnaevsPHVTEEDLR 233 Histoplasma cap...
XP_006965141 173 ----RIAALRARFRHGRDTTAYYEARVAEQAEQLAGMNNDKGWMGgedqdrdea---------gtvvdaggDEWTEEDLR 239 Trichoderma ree...
ERT02684     173 ----RIPVLRQKHAQQTSTLTYYEAKVAEQAQRLEGMNHDRRGGEgefdgdndms-------maaaapaaaDGLTDDDLR 241 Sporothrix sche...
EJT75418     175 ----RIPELRRRHAHQNNTLAYYEARVAEQAERLARMNRDHYADDydddkageeee----keedgaaaggdDGMTEDDLR 246 Gaeumannomyces ...
ABN65516     195 --meKLNAHQTDYVQLQEQINQLENEIETQKKQLNILNINYNDITspirsessgh-------mrtresfedEIDIDEYIA 265 Scheffersomyces...
Q6BNC4       199 sllsDIVVYHQEYNSLTNEIYELEEVVAEQKDQLNFYNINLSERSpidrspirghkrsheessddtenpddSVDIDELIA 278 Debaryomyces ha...
XP_004194628 196 rivrDLKAQHAEYATLVKEIEELEEVISEQKKQFNFYNINLSDKSslspsrrhqqdssedaevqpseeslkEVDIDELIR 275 Pichia farinosa...
EDK38701     173 ---eKISEYSREYEELSTGMRQYRATIDEQRRRLKAYNSGTLEQQnt----------------------sdEIDIDELIR 227 Meyerozyma guil...
XP_004182107 236 ----KYQTLWEEYSTLTQQVTSLKEDIEYQTYRLNNTNTNNHASSp------------------------pSKSVADMIA 287 Tetrapisispora ...
Q6FLI2       291 KERQKIAELESQLRIS 306 [Candida] glabrata CBS 138
EEH03592     234 REILEIHELEARKQKL 249 Histoplasma capsulatum G186AR
XP_006965141 240 REEEETRLMERKKREL 255 Trichoderma reesei QM6a
ERT02684     242 HEEDEIRELERKKKEL 257 Sporothrix schenckii ATCC 58251
EJT75418     247 REEEGVRELDRKKREL 262 Gaeumannomyces tritici R3-111a-1
ABN65516     266 KEEQEIEELENQLNER 281 Scheffersomyces stipitis CBS 6054
Q6BNC4       279 QEESEIQELEDQLTKR 294 Debaryomyces hansenii
XP_004194628 276 QEEEEIAAYEEDLTKR 291 Pichia farinosa CBS 7064
EDK38701     228 NEEEAIEKLEQQLTQE 243 Meyerozyma guilliermondii ATCC 6260
XP_004182107 288 KEEREIERLQTELNEK 303 Tetrapisispora blattae CBS 6284
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