6CFZ


Conserved Protein Domain Family
DASH_Ask1
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pfam08655: DASH_Ask1 (This model is not part of the current CDD release)
DASH complex subunit Ask1
The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules.
Links
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Statistics
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PSSM-Id: 518410
Aligned: 41 rows
Threshold Bit Score: 89.8957
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6CFZ_A         7 LEKLEQQITLTLQEIDSNFAKAHRIVTTSILPLVEQYGEHSRAVWEATKFWKQFFEASANVSLS 70  Thermochaetoides thermophila
XP_013935438  22 LSKIEQEITLTLQEIDKNLSVSNSIINESVIPRLAKFRHSSSKIWSNVEFWKTFFENSANVEIT 85 
XP_011276027  38 LERIEQEITLTLQSIDKNFAKSHRIINEKLIPIITKYHQNSIKIDQSVGFWKNFLQFSANSELK 101
XP_002617631  24 LERLEQASTLLLQEIDHNLSRANAIIGDSIFPVLKKYAAATAQASSHVGFWKHFLEEAADVEIS 87 
XP_001482207  32 LEKLEQEITLTLQEIDKNLSKANAVISEKMFPILAKYAQSSQKVWNNANFWKYFLEQAADVELT 95 
CCE86472      38 LERLEQEITLVLQEIDKNISKANAVINDKVFPVLRKHAASSTSVWNNVNFWKYFLEQSANVELT 101
EMG48264      30 LEQLDQDTTLVLQQIDRNLSRANTIINNKIKPMLQEYGIQSSKVWENAGFWKHFFEQSANVELD 93 
EDK46181      28 LEQLDQDTTIVLQDIDRKLSRANAILNDLIKPTISEYMKESSKIKQSTGFWKKFFELSANVVLD 91 
XP_036667498  29 LEQLDQDTTLVLQDIDKNISRANAIINDKLKPVIQEYGVESWKVWHNSGFWKKFFEQSANVVLN 92 
XP_001387495  32 LERLEQETTLVLQEIDKNISRANSVINDRLIPVIKDYSSETRKVWNNAGFWKYFFEHSANVELN 95
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