5N9J,6XP5,5OQM


Conserved Protein Domain Family
Med14
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pfam08638: Med14 (This model is not part of the current CDD release)
Mediator complex subunit MED14
Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.
Links
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Statistics
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PSSM-Id: 518395
Aligned: 125 rows
Threshold Bit Score: 105.647
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5N9J_A         24 FYPLPEIVETFSHHVLQELVSLAEVLPSMS----NVEKKKKILDWLLRSRAFTMRLLVLARWVHLSPSVHRCIDVVAFLQ 99   fission yeast
Q03570        104 TIPLNVLLDFAIQHVYHEITVLAELMQRKTndqgEQERKMSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYSIDYLLD 183  Caenorhabditi...
XP_002108101   15 KIKLSTLMDFIIQKAYHDLNVLTEILPRKG----DVERKIAIYRYSASMRQQFVRLLAIVKWATKAEKIEKCFQLCDFLE 90  
XP_048587940   10 KINLSMLIDFLLQKTYHELTVLSELLPRKP----DIERKIEIVQFASRTRQQFVRLLALVKWAGGAKGVAKCQAISTFLD 85  
XP_015794906   18 TMSLSRLVDFTVQRTYHELLILTDLLPQKS----DIERKIEIISFANRTRQLFIRLLALVKWAGSASKVEKCSTIVAFLN 93  
2_pfamImport    1 SLSLSVLIDFIVQRTYHELTVLAELLPRKP----DMERKIEIYKFSNRTRQLFVRLLALVKWANSASKVDKSTQIMGFLD 76  
EDW30113       30 TMSMSMLIDFIIQRTYHELTVLAELLPRKT----DMERKIEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLD 105 
XP_046458830   32 SISLTVLIDFIIQRTYHELSVLAELLPRKT----DMERKIEIYQFASRTRQLFVRLLALVKWAASVSKVDKSANIMAFLD 107 
XP_009026619   19 VVPLSTLMEFLIQRTYHELSILSELLLGKN----DLERKIEICQFANRTKQTFVRLLALVKWTNSANKVDKCARIFSFLQ 94  
XP_001578925   16 PYPLHDVVAHFVSRSFSALTNTLEV--NSE----DTVHNLELMRVLNTIFVNATKVLMLFRWNNIYPQSSDICNYLMATR 89  

5N9J_A        100 GQKFCFQNLVHVL-QDIRYQLSFARLRNSDLVTALDILSTGTSLRLanaPTSKly-mlSESPL--STKQILQTLHALNML 175  fission yeast
Q03570        184 LQSQYFIDTADRLvAMTRGDLELARLPEYHIAPAIDVLVLGTYNRM---PSKIkeafiPPAKI--TPREQKLVTSRLNQL 258  Caenorhabditi...
XP_002108101   91 QEGKIFVDTADELyRIANEMLPQAKLPYFDLISAAEVLSRGSYSLL---PTCIkdkiiPLPPM--TRDDKKTTLQKLNEV 165 
XP_048587940   86 QQSMVFVDTADMLaRMARETLVQARLPTFCLPAAVDVLTTGTYQRL---PTCIrdkivPPDPL--SLSEKNKTLQRLNEV 160 
XP_015794906   94 KQAMFFIETADSLaKMARENLVQARLPALQLPAAVEVLTLGSYTRL---PTCIrdrivPPDSI--TPAEKKATLQRLNQI 168 
2_pfamImport   77 KQSLLFIDTADMLsRVARETVVSARLPNFHIPSAVEVLTTGTFSRL---PACIrerivPPDKI--TPAEKRETLLQLNRV 151 
EDW30113      106 KQNMLFVETADMLaRMSRETLVRARLPNFHIPAAVEVLTTGTYNRL---PTCIrerivPADAI--TPAEKKQTLLRLNQV 180 
XP_046458830  108 KQSMIFIETADALsRMARETLVHARLPNFHLPAAVEVLTLGTYSRL---PLVIrdkiiPPDPI--TAVEKKNTLSRLSQV 182 
XP_009026619   95 QQQLLFVETADCLaRMARETLVHARLPSFSLPCAIDVLMTGTYPRL---PFCIkekivPPEPL--PPLEKKRVLTKLTQV 169 
XP_001578925   90 AQAKFIQDYLTNMlRLYNSEMDRLKTPMYDVMGAIDVIVGRGYSRL---PLMIy----PPLAIpkYEKDPQGMLNLIKDK 162 

5N9J_A        176 IRIRLSL-YEIIPTPFQHFTIANGRCTFTVPNEFSVSLTT 214  fission yeast
Q03570        259 IESRLSRlSSGIPPNIKEIHINNGLATLLVPGEFEIKITL 298  Caenorhabditis elegans
XP_002108101  166 IKDRLL--RSNVPQGISKTVIGNGQLTLTVEGEFEVVLTL 203 
XP_048587940  161 IQHRLV--LARIPPQMASLKIADGCVTFHVDNEFEVSLTL 198 
XP_015794906  169 IQQRLV--ISNLSPQMKNFKIDHGRVIFHVNHEFEMALTL 206 
2_pfamImport  152 IQHRMV--CSNLINEMSCKKVANGRVTFRVENEFQVSLTL 189 
EDW30113      181 IQHRLV--TGKLLPQMREFRIKNGRVTFEVKHEFSVALTV 218 
XP_046458830  183 IEYRLA--TTTLPTQMRKNKIENGRVKFTVDHEFEATLTL 220 
XP_009026619  170 IEYRIV--MNDLPHSMCKPVIENGRVKFTVDHEFEVFLTL 207 
XP_001578925  163 LITYLT--SQTLPMH-SRVTFENGVAKIHVPNQYNLYLSY 199
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