Conserved Protein Domain Family
Pet127

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pfam08634: Pet127 
Mitochondrial protein Pet127
Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localised to the mitochondrial membrane. The Pet127 family is part of the PD-(D/E)XK nuclease superfamily including a full set of active site residues.
Statistics
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PSSM-Id: 489760
Aligned: 90 rows
Threshold Bit Score: 286.695
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q75A95        150 FVPPSRDLRLLERAKEGQARYVSSTSAMSGVLSHLHYLLSNFRPLNGRHLSATL-LR---KDAQVTKCCKMTSSMLLQRr 225  Eremothecium ...
ESK94953      190 FVKSSSDEDLWSLARKEGRRFGGSTSSLSGMLSQIYFLISENKEVDTSTLSAGF-RR---QPSNFTPGQRMAASVVFNY- 264 
XP_003034447   79 FVKSSRDEDLRTLAVREGKSFAGSTSSLTGMLSHIYFLISGDRNVDISPLSRAF-ED---KPVDFTPGQRSPASTVFNY- 153 
XP_006675345  181 YTIASKDKVLKKMAIKYKRKYYASTSSITSVLSKLILSITGMRPVNLDRLSIPF-IE---KSALHTKFSCGPTGIVLKY- 255 
XP_004361794  376 YMIPSQDPELLTKTSDFKCKFLSSTSSITSVLAAMYLSVFKKYTVNQFGLNSQLq-----SMSKFTPQVLKPTAITLTAv 450 
Q54T03        594 YMRPSEDKRLLDITKEHKAKYLSSTSSITSILTHLYLSLVKGKAPSSSPFSPPIlTRllpLKMGFIPSIVKPTSIHLTPl 673  Dictyostelium...
XP_003292100  409 YMIPSEDQKLIEITEENKCTYFSSTSSITAFLTHLYLAVSKSKAPPSSMYSSSL-TD---LSGSFIPSVLKPSSIHLIPv 484 
Q24CB9        192 YIPPSNDKLLLDFAKQSNIRYVMSTSTISNVLSQIYFLFSSFRNPNFDNISSAY-DQ---EPKKYMISQRKPTSNMLRkl 267  Tetrahymena t...
XP_004040013  157 YIPPSNDQLLLDFAKKSNIKYVVSTSTISSALTQIYYMFSGFRNPLYDNISSNY-EN---EPKKYMISQRKPTTNYLRrl 232 
XP_002681093  476 FIPPSQDTTLHKLMDQNPCRYQSSTSSITSPLVSLYLALSNYKPTRARNLENFKy-----LTSSFTPAVRKPVVFILRPk 550 
Q75A95        226 sQa--PPIFSLSSDS-----SADR-EIILSQLGHALEALLTTDQADFA-RIYDKGk-------RAQPgsqplgkghaTSA 289  Eremothecium ...
ESK94953      265 -N---DGVYAIDSDPsk-seEAEK--NILTWMGTLLEKYLTMSTEEFL-AYMRTHpqpv-iedEKVSdg------ptREA 329 
XP_003034447  154 -K---DGVHMIDSDEdkpgvKSDQ--NILTWMGTLLEKYFTMEPEEFA-RYLRAHd-------HPQTesd-----nmREA 214 
XP_006675345  256 -S---DGVYGIDHYK-----PSEEtRNVLMQLGHVLEAMLCEDKKSFK-RLLKTDnastditlSPS-------------T 312 
XP_004361794  451 kDd----IWAIDINNg----NIPKkNEVLMELGHSMEKMLTLEEEEFLaKLLKTNnsvpv---------------efddS 507 
Q54T03        674 dGg----IWAIDTNSg----NITQdNTILMNLGHSMEKMLTLDEEEFNqKLLKSNvgdkp--------------vefpdS 731  Dictyostelium...
XP_003292100  485 kDn----IWSIDNNSg----NAEKsNVILMNLGHSMEKMLTLPEDEFNsKILKSNnpgdp--------------vefpdS 542 
Q24CB9        268 d--pknGIYALDSDSgl-feTPNQ---ILMDLGKVMERQLTLDPETFRnGLLKNSpvkeq--------------lidddH 327  Tetrahymena t...
XP_004040013  233 d--kekGIYAFDSDSgi-feAPNK---ILMDLGKILEKQLTLDEQTFKdALLKTStknil---------------ieddH 291 
XP_002681093  551 lSklghTFYSIDSYKfl-fePRSN--QILMDLGKVMEKLFVMEPEDFEkRFVKQYcgeeqt-------------vedeeV 614 
Q75A95        290 FRFNK-HGRFLLRSQLDAH--DPKL--P-GTGVFDLKTRAVAAVRHDLDYVSQNgntTGYQLMRRSGQFESYEREISELV 363  Eremothecium ...
ESK94953      330 YRYSK-SEKFVMRSQLDCH--DNRL--P-GTGVFDIKTRACMPIRMDILNFKES---SGYLITKQHGLTESFEREYYDLV 400 
XP_003034447  215 YRYSK-SQSFIMRSQLDCV--DPRL--P-GTGVFDMKTRACMAIRMDLLNFEES---SGYLIRQQHGLLESFEREYYDLI 285 
XP_006675345  313 YSYSL-AENFLMRAQLDCQ--HPDL--P--NKSFDIKTRATAAIRFNSNDYQSH---TGYKIRKLTGVYESFEREYFDML 382 
XP_004361794  508 YVFTK-FDNLMYRSQIDCY--SDKIkgKgERMTFDLKTRATRQIRYHVWEHDVH---LDYHLKNVVGLNESYERELSDMT 581 
Q54T03        732 YIFSK-FGSLIYRSQLDCK--SDHL--PeGRNTFDLKTRSTSSIRNNASTSFNY---VSQRISRLSSDKDSFESEYFDLT 803  Dictyostelium...
XP_003292100  543 YIYSK-FDKIIYRSQIDCI--SDNL--PeDRNTFDLKTRATNAIRMNVSETNNF---ISHHINRLFNCNNSFEREYLDLS 614 
Q24CB9        328 HRFMKlNKNICLRSQIDCQaiDPKTgqP---FVFEIKTRAVCPIRYDLNNYLDH---IDYRINTKFGLHSSFEREYYDLI 401  Tetrahymena t...
XP_004040013  292 HRFMKlNGDICLRSQIDCTaiSKETnqP---IVFEIKTRASCPIRYDLENYKDY---LDYRIVQKYGIHSSFEREYYDLI 365 
XP_002681093  615 YRYLR-HGSFLLRSQLDCY--HPQY------GVFDIKTRATNPIRINMEKYQKF---TNIKLKMIKGNYNSYEREFYDMV 682 
Q75A95        364 RNAMLKYSFQARIGAMDGIFVAYHNISRIFGFQYIPLEEMDYIIHSsadraaamsltrresalqelfnpveyvtryrfen 443  Eremothecium ...
ESK94953      401 RSAFLKYSFQARIGNMDGVFVAYHNTARMFGFQYVSLDEMDQRLFS---------------------------------- 446 
XP_003034447  286 RSAFLKYSFQARIGNMDGIFCAYHNVARVFGFQYFGLEEIDARLFG---------------------------------- 331 
XP_006675345  383 RSTFLKYSLQVRIGKMDGIFVSYHNTASIYGFQYIPLEQMDEDLFG---------------------------------- 428 
XP_004361794  582 RSSGIKYAFQAKIGNMDGLYIAYHNTKKIFGTEYLPLEKLERIVFW---------------------------------- 627 
Q54T03        804 KSGAIKYALQAKIGHMAGIFICYHNTKRIFGSEYLDLEELEKSVFW---------------------------------- 849  Dictyostelium...
XP_003292100  615 RSGGIKYALQAKLGHMAGIFICYHNTRKIFGSEYIDLKELEKSIFW---------------------------------- 660 
Q24CB9        402 RGAMLKYAFQLKIGRMDGAFIAYHNTKEIFGFEYVKTKEIETRCFG---------------------------------- 447  Tetrahymena t...
XP_004040013  366 RGGFLKYCFQLKIGRMDGAFIAYHNTLEMFGFEYVKTTEIENRIFG---------------------------------- 411 
XP_002681093  683 RSVFIKYSMQGRIGGMDGMFLAYHNTVELFGFEYIKLGEIDKHVFG---------------------------------- 728 
Q75A95        444 tarEtAstLAQAEFNYSMRILEHLFD 469  Eremothecium gossypii
ESK94953      447 ---Q-HkgAGDRVFQKCVELMEVvad 468 
XP_003034447  332 ---M-EpgAGDRVFRKCVAMLETVae 353 
XP_006675345  429 -----NstFADDSFAFSVKLFNRLLD 449 
XP_004361794  628 -----GnhIADDVFRITSTLLDKILt 648 
Q54T03        850 -----StdMANRSFLMTNSILEDLLN 870  Dictyostelium discoideum AX4
XP_003292100  661 -----TnhMADVNFNLTNQLLQNVLD 681 
Q24CB9        448 -----NqfFADASFVVCSKILTNLLD 468  Tetrahymena thermophila SB210
XP_004040013  412 -----NtlFADASFVICSKILTNLLN 432 
XP_002681093  729 -----SphMAERFFSLLLDLLGEVLD 749 
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