Conserved Protein Domain Family
Nha1_C

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pfam08619: Nha1_C 
Alkali metal cation/H+ antiporter Nha1 C-terminus
The C-terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water. This domain is found with pfam00999.
Statistics
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PSSM-Id: 400785
View PSSM: pfam08619
Aligned: 54 rows
Threshold Bit Score: 182.541
Threshold Setting Gi: 74660457
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAR25108      463 WMQRLPSLDKSGRSFslqRIDTkASPEtlarq-----------etveTSgVPAKPAGGMKRK---RRKLRNRIKKdlfrs 528  Lachancea the...
Q6CQI7        464 WMDRLPGLEKEGRSYsihRVDTmASDAtkplkk---------ndtveTSgIRAKPVGGMKRR---GKKSKKRGLRhrgng 531  Kluyveromyces...
XP_001524316  465 WIQRLQKLDRTSSSFslqRVDTmAPEElqnlknka-----eqmnvpeTSgLKVRPAGGAKRR------TKKKKKHnhgll 533  Lodderomyces ...
CCE44430      468 WMQRLQKLDRANTSFslhRVDTmAPDEkeeqpdeq-----eqtqlpeTSgVKVRPAGGAKRR------KKKRRSQkpgli 536  Candida parap...
EGW30681      462 WMQRLQKLDKTSTTFslhRVDTiAVTEkekptdeq-----gvatgveTSgIKVRPAGGAKRRaqlKKKKKKKKKKpahii 536  Spathaspora p...
EMG47527      464 WMQRLQKLDRANTSFslhRVDTmAPPDdkekvqeef---esppegpeTSgIKVRPAGGAKRR-----KKKSRRSKqpgli 535  Candida malto...
EER35378      466 WMQRLQKLDRTSTSFslqRVDTvAPGDekekdsekmqreetlpegpeTSgIKVRPAGGAARR-----KKKKKRSRqprll 540  Candida tropi...
EDK37276      370 WMNRLQKLDKASTSFslhRIDTaVPGDeemer----------sntieTSgVKVRPAGGAKRK-----RHKKKRRGaasnl 434  Meyerozyma gu...
Q6BMF1        463 WMSRLQKLDKASTSFslhRIDTqAPSTekghklq-------qsntveTSgIKVRPAGGAKRR------KHKKKRDprsrl 529  Debaryomyces ...
XP_011275006  462 WMSRLPELKSNGRSFslhRIDTmAPSThsasasgaeagqlsqaptveTSgIPARPAGGMDRRkkkSKKSKKRRSHlhkih 541  Wickerhamomyc...
CAR25108      529 rtnng-----------gngedsenlDSERLQreKEAQAAAFALSAELHHDDDas-------------------------- 571  Lachancea the...
Q6CQI7        532 a------------------eeknslEIEREIrqKEAQAAAFALSRDDESDLGaksfts---------------------- 571  Kluyveromyces...
XP_001524316  534 lrtls----------rvrtgddqreERHRPVt------eSLQLGGLGTGAGVgagaksnfssepdt-------------- 583  Lodderomyces ...
CCE44430      537 qktlsr--------vtsgddekthqPRHRPHq------eVLQLGGGSQQQQQqqnsptk--------------------- 581  Candida parap...
EGW30681      537 kktlskvttggmsdeeeeeeyehktDRQRPQt------eFLQLGRSNNLAPse--------------------------- 583  Spathaspora p...
EMG47527      536 kktls-----------ratsrdedeKRARPEa------qFLQLGNRNANTedeksmsefeper----------------- 581  Candida malto...
EER35378      541 qktls-----------rvatrdedeKRVRPEa------qVLQLGGRGPTETFdddhkssaesspem-------------- 589  Candida tropi...
EDK37276      435 kktlsm--------ansesdaasmnQRQRPHt------eFLQLGRSTSNAPPdesipv---------------------- 478  Meyerozyma gu...
Q6BMF1        530 kkslsra------sadseadeivpsQRHKPQa------eFLQLGRTPSTAIRtpsdeesepesa---------------- 581  Debaryomyces ...
XP_011275006  542 shhg------------dsnadttaaDIEKLQreREAKAAAFALGGPRREESQqqntnssspddsfvqqgitpattfnekv 609  Wickerhamomyc...
CAR25108      572 ---------------------dATDIDAEATGTDAETEEGtieeplelvdvmdpseashtinrldaishgekvdteslgh 630  Lachancea the...
Q6CQI7        572 -----------------ledpnSLEKQQQTSLNSSEAGQEppqrpvqssgitprp------------------------- 609  Kluyveromyces...
XP_001524316  584 ---------stnevkassssstESDQQEKRAGTTNEDSEEngd------------------------------------- 617  Lodderomyces ...
CCE44430      582 ---------------stistssEPEVTAEVKNSSSSTEGE---------------------------------------- 606  Candida parap...
EGW30681      584 ---------------------tSEDTVEEKPSSPKEDTSVe--------------------------------------- 603  Spathaspora p...
EMG47527      582 ---------tttneikgsssssEEGGAAISSTTAEQGEVApqvfvspp-------------------------------- 620  Candida malto...
EER35378      590 ---------attnelknsssssEHDRVANEPAQPEfvispps-------------------------------------- 622  Candida tropi...
EDK37276      479 ----------------seeslnSPETESPQTGIDEKDNDSvpsle----------------------------------- 507  Meyerozyma gu...
Q6BMF1        582 ----------vgidnskedfddSPGSSNSIEVVANEDQGRmvfa------------------------------------ 615  Debaryomyces ...
XP_011275006  610 pwptggndeeaqlngsdlynetTESDEKQQSSETSENNDG---------------------------------------- 649  Wickerhamomyc...
CAR25108      631 qsqkskpepspsnslegqspnqgttttsssnfdeekldreSQAASAASMdsyardleklRKDMEAKRDEEEGAVAYTEGN 710  Lachancea the...
Q6CQI7        610 -------------------------tfadekipfpssqisGNSEAESGPrpggssesgsKTSEEFPLATDQANVAYQEGS 664  Kluyveromyces...
XP_001524316  618 -------------------------------------ggdEFITSPGILekqsgkskygLHPSRTKDRERIPTAAYQEGD 660  Lodderomyces ...
CCE44430      607 -------------------------------------------HLLDPNektsgksqygQR---SRPEVPVPTSAYQEGD 640  Candida parap...
EGW30681      604 ---------------------------------------tEETMQGGVPdktsgmkkygQRPPTEEEKRSIPTVAYQDGD 644  Spathaspora p...
EMG47527      621 --------------------------------sptsdkiqLSSSPPTTPkktsglseygQKQPTKLEKAPVPTVAYQDGD 668  Candida malto...
EER35378      623 ----------------------------------psihepQVEEPEQIPkktsglskfgQRMPTKAEKAPVPKVAYQDGD 668  Candida tropi...
EDK37276      508 -----------------------------------ventgEKIAIAVPHgsqqdaeadkVDHRTTERKQSVATVAYQEGN 552  Meyerozyma gu...
Q6BMF1        616 -------------------------------------vppYDSHGRVEQdedqdngkvsFARNAMEGRKSVPSTAFQEGE 658  Debaryomyces ...
XP_011275006  650 ------------------------------------------------------------AGGEDYERNRRPSAAYTEGD 669  Wickerhamomyc...
CAR25108      711 KIIVENKDGEIIdqaelN--RKPRDEEEGpdstt--------------------------pqdrkSRSRSYSINSLKR-- 760  Lachancea the...
Q6CQI7        665 RIILENRKGEVVdeaqlVprEDVLNDHAEl----------------------------------sTTPTNHTINSLKR-- 708  Kluyveromyces...
XP_001524316  661 NLIVEDQHGEILdnlklNtlPVGQRKPVGkae------------------------------sknDDDSIHSMESLQR-- 708  Lodderomyces ...
CCE44430      641 NIIIEDQFGEIMdnltlGkrGEAVEKRRKsqssnapvsspgvasvaaaaaaddaqhegddegaegDDESIHSMGSLER-- 718  Candida parap...
EGW30681      645 QIIIEDQYGEIMdslklQqrAKPAPVEPVesftn---------------------------inddDDASVHSEASLQR-- 695  Spathaspora p...
EMG47527      669 QVIIEDQYGEIMetlklTskPDRQKLEEMtgeaprp-----------------------prrhsaDSGSIHSMESLER-- 723  Candida malto...
EER35378      669 KVIIEDQYGEVMeilqlShkDDIKKLQGSrpssppav--------------------dtsarqsqDSDSIHSMESLER-- 726  Candida tropi...
EDK37276      553 KIVIEDENGEVVetlpmKgnKAIAKAARGe-----------------------------------DNMSIHSAESLRR-- 595  Meyerozyma gu...
Q6BMF1        659 KIIIEDQAGEIIetlplKslQGQPENE--------------------------------------DDLSIHSMNSLSR-- 698  Debaryomyces ...
XP_011275006  670 KLIIEDQHGEILdqanmDvpDRLKKNDSSrssrsk------------------------ksstkrSKSPSSSINSLTRkt 725  Wickerhamomyc...
CAR25108      761 -----ALTPPrmrrq---------------------------------------------------tlvdeQANKRYFAY 784  Lachancea the...
Q6CQI7        709 -----VLTPTrfrhs---------------------------------------------------tlvdtDTSKKFYAY 732  Kluyveromyces...
XP_001524316  709 -----RLSQYsiasdksresmkqdemragatsgatsgpekrkpsiaqsaashilpkikrtesrrtyykkddPKRRKVYAH 783  Lodderomyces ...
CCE44430      719 -----QLSQYsngstiksgpsdsdttqdttggk----------------ksplhkrisrsasrrsyyrkddPHRRKVYAH 777  Candida parap...
EGW30681      696 -----RLSQYasadseysfndekqeqddtdls-----------------pirkrisrsiskktkvlyrkddPHRKKVYAH 753  Spathaspora p...
EMG47527      724 -----HLTQYstvssgtvdsevdekdhhlgl-------------------splqkklsrtlsrrsyykkgdPNKHKVYAH 779  Candida malto...
EER35378      727 -----HLTEYsnassgtekegessdadhlgl-------------------splqqkisrtlsrrsfykkddPHKRKVYAH 782  Candida tropi...
EDK37276      596 -----QMTQYstasnssnqsrtqtlee---------------------------rlskvpsrrrafykkgdPGQRKVYAH 643  Meyerozyma gu...
Q6BMF1        699 -----QLSKYstaqsdrtstetslntkekpnsplg------------klarssslslgrkgkrkgyykkndPKHRKVFAH 761  Debaryomyces ...
XP_011275006  726 ssileRVNSGn------------------------------------------------------------RDRPKYTAY 745  Wickerhamomyc...
CAR25108      785 KIDDQLIIENDDGDVLRRYKInphaeagakpapkrkptgvv---------akalsavglskgssrapsenTSgsSAQGDV 855  Lachancea the...
Q6CQI7        733 KYGTQLVIETDKGEIVRRYQInqhsspttesptttkprsnsv-------vakalsmvklgksstskqhpdSAqrPTSASS 805  Kluyveromyces...
XP_001524316  784 RIDNLILIENEDGDIIRRYKVnrhasnipkpnrsrsstl--------------vgkmksfvgmkdkeqqqQAlaSSLAGA 849  Lodderomyces ...
CCE44430      778 RIDNIITIENEDGDIIRRYKVnrhvsnppnptpnrs-------------------rsstlvgkmkslvgmKPntTATATA 838  Candida parap...
EGW30681      754 QVDDLIVIENEEGEIIRRYKVnrhhskfrnppqeqeggt-------------rprsttlvgkmksilgfnESepTSPTTP 820  Spathaspora p...
EMG47527      780 RIDDLIVIENEDGDIMRRYKVnrhtgnptttpqqqqqqadpnqptsgnktrsrsgtlmgmmksivglkpsDKtkSASPET 859  Candida malto...
EER35378      783 RVDNLIVIENEDGEVIRRYKVnkhaadpaqqaaqsksra-------------rsgslmgmvksivgmksgNSnpSSPTAT 849  Candida tropi...
EDK37276      644 QVDNLIIIENEDGDIVRRYRVnkhstnrersgsl-----------------------mnralskvgirsrQGstSAPEPV 700  Meyerozyma gu...
Q6BMF1        762 QVDNFIVIENADGDIIRRYKVnrhtanrarsntgn----------------------smvgkalnfvglkKNnpKNNVDA 819  Debaryomyces ...
XP_011275006  746 KLDNQLIIENEDGEILRRYKInhhktvqqktrsgs---------------------iaggfgkalsavgiKSniGANKDE 804  Wickerhamomyc...
CAR25108      856 AQpqssvakirdrrltpvpt------------------------------------------------------------ 875  Lachancea the...
Q6CQI7        806 GSslnsrqnfknkviarqltp----------------------------------------------------------- 826  Kluyveromyces...
XP_001524316  850 NGelqqqhqqqqqqqptvhvtdlekgthhtilvpqddeknqhsphladgldkvedkiagilesrhqhgghelvrrasppp 929  Lodderomyces ...
CCE44430      839 TTttntshtgastnqtptnpdevsqvhvtdlekgthhnilipeavrdphpds-------akldkiedkiatiletkhqtg 911  Candida parap...
EGW30681      821 TIqvsnydleqgnsnmiiphegdegdtkleh------------------------------------------------- 851  Spathaspora p...
EMG47527      860 SVpistlnsdleqgnsnpvlvadvgnqpldsrteqkledklanml--------------------tqksetgnkatvtrm 919  Candida malto...
EER35378      850 SPqtsatanfdlekgnmnrvllphneeelhehmgsklehkledklts----------------ilehgqdtgsksqptrk 913  Candida tropi...
EDK37276      701 LTqvhdstkpnsplrdskletkienqlvdiftkkkg--------------------------------------pgqpkg 742  Meyerozyma gu...
Q6BMF1        820 NDlekndienilipehddtnnpnhplknpkfenaiesk-----------------------------------ltkilld 864  Debaryomyces ...
XP_011275006  805 SPldnsnteikdhlqlepleqpep-------------------------------------------------------- 828  Wickerhamomyc...
CAR25108      876 -----------sgamdvgssedeeeeseEDGSSDEESERAIDDEPEsASDYDGSEDGSYTdeg------fsdEEPETAIE 938  Lachancea the...
Q6CQI7        827 ----------lpvvdhlseedddddnedDDDYSDEENS---------ENISSEEEDTSADdd--------eeEEDETEVE 879  Kluyveromyces...
XP_001524316  930 pihgdineegededgdvvddddengedsEEYDTDSDEEEEEEEEGG-DGHGELMDDEAESd------------eEETSVE 996  Lodderomyces ...
CCE44430      912 hhsairkasppppppnrlgddavdeyddEDSTADEEEE----------------EDEDESd------------dEETEVE 963  Candida parap...
EGW30681      852 klsnmlskkksppprvlsdedeedsnesQDSEEDVSEV------------DSEVDSEEDSd------------eHETEVE 907  Spathaspora p...
EMG47527      920 ssppasqqqqqhpiveasdedlensdlsQDSEVED----------------------DDDd------------eEETEVE 965  Candida malto...
EER35378      914 asppppahrnnafddeeeeeeeedselsEDSEADE---------------------------------------EETEVE 954  Candida tropi...
EDK37276      743 qaaiqrkrspppavaeatdededqedydHDSEDDDASV------------------DSEEde----------ilQESNVE 794  Meyerozyma gu...
Q6BMF1        865 drskssnflsvgnksetiqedsergvsdDDYDTSSGSE----------------ETDEDEdq----------vlEETDIE 918  Debaryomyces ...
XP_011275006  829 ------vranddsiheeadsdleeitsgEEESDSEE--------------VDSDEDSEESdddediaprpagFQEETAAE 888  Wickerhamomyc...
CAR25108      939 RARRLTALGHVSAp-rREDDEE 959  Lachancea thermotolerans CBS 6340
Q6CQI7        880 RARRLTALGISTAp-rHQDDEE 900  Kluyveromyces lactis
XP_001524316  997 RARRLQALGRIPNrnrDEDDEE 1018 Lodderomyces elongisporus NRRL YB-4239
CCE44430      964 KQRRLQALGKLPNrnrDQNDEE 985  Candida parapsilosis
EGW30681      908 KRRRLQALGKLPVh-rHQDDEE 928  Spathaspora passalidarum NRRL Y-27907
EMG47527      966 KRRRLQALGKLPTtrrHEDDEe 987  Candida maltosa Xu316
EER35378      955 KRRRLQALGKLPTgrrNRDDEE 976  Candida tropicalis MYA-3404
EDK37276      795 RQRRLAALGRIPDk-rDRDDEE 815  Meyerozyma guilliermondii ATCC 6260
Q6BMF1        919 KKRRLAALGQMPTh-rRKEDEE 939  Debaryomyces hansenii
XP_011275006  889 RDRRLAAIGQVDAp-rDESDEE 909  Wickerhamomyces ciferrii
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