Conserved Protein Domain Family
Nha1_C

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pfam08619: Nha1_C 
Alkali metal cation/H+ antiporter Nha1 C terminus
The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water. This domain is found with pfam00999.
Statistics
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PSSM-Id: 400785
Aligned: 54 rows
Threshold Bit Score: 184.852
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAR25108      463 WMQRLPSLDKSGRSFslqRIDTkASPEtlarq-----------etveTSgVPAKPAGGMKRK---RRKLRNRIKKdlfrs 528 
Q6CQI7        464 WMDRLPGLEKEGRSYsihRVDTmASDAtkplkk---------ndtveTSgIRAKPVGGMKRR---GKKSKKRGLRhrgng 531  Kluyveromyces...
XP_001524316  465 WIQRLQKLDRTSSSFslqRVDTmAPEElqnlknka-----eqmnvpeTSgLKVRPAGGAKRR------TKKKKKHnhgll 533 
CCE44430      468 WMQRLQKLDRANTSFslhRVDTmAPDEkeeqpdeq-----eqtqlpeTSgVKVRPAGGAKRR------KKKRRSQkpgli 536 
EGW30681      462 WMQRLQKLDKTSTTFslhRVDTiAVTEkekptdeq-----gvatgveTSgIKVRPAGGAKRRaqlKKKKKKKKKKpahii 536 
EMG47527      464 WMQRLQKLDRANTSFslhRVDTmAPPDdkekvqeef---esppegpeTSgIKVRPAGGAKRR-----KKKSRRSKqpgli 535 
EER35378      466 WMQRLQKLDRTSTSFslqRVDTvAPGDekekdsekmqreetlpegpeTSgIKVRPAGGAARR-----KKKKKRSRqprll 540 
EDK37276      370 WMNRLQKLDKASTSFslhRIDTaVPGDeemer----------sntieTSgVKVRPAGGAKRK-----RHKKKRRGaasnl 434 
Q6BMF1        463 WMSRLQKLDKASTSFslhRIDTqAPSTekghklq-------qsntveTSgIKVRPAGGAKRR------KHKKKRDprsrl 529  Debaryomyces ...
XP_011275006  462 WMSRLPELKSNGRSFslhRIDTmAPSThsasasgaeagqlsqaptveTSgIPARPAGGMDRRkkkSKKSKKRRSHlhkih 541 
CAR25108      529 rtnng-----------gngedsenlDSERLQreKEAQAAAFALSAELHHDDDas-------------------------- 571 
Q6CQI7        532 a------------------eeknslEIEREIrqKEAQAAAFALSRDDESDLGaksfts---------------------- 571  Kluyveromyces...
XP_001524316  534 lrtls----------rvrtgddqreERHRPVt------eSLQLGGLGTGAGVgagaksnfssepdt-------------- 583 
CCE44430      537 qktlsr--------vtsgddekthqPRHRPHq------eVLQLGGGSQQQQQqqnsptk--------------------- 581 
EGW30681      537 kktlskvttggmsdeeeeeeyehktDRQRPQt------eFLQLGRSNNLAPse--------------------------- 583 
EMG47527      536 kktls-----------ratsrdedeKRARPEa------qFLQLGNRNANTedeksmsefeper----------------- 581 
EER35378      541 qktls-----------rvatrdedeKRVRPEa------qVLQLGGRGPTETFdddhkssaesspem-------------- 589 
EDK37276      435 kktlsm--------ansesdaasmnQRQRPHt------eFLQLGRSTSNAPPdesipv---------------------- 478 
Q6BMF1        530 kkslsra------sadseadeivpsQRHKPQa------eFLQLGRTPSTAIRtpsdeesepesa---------------- 581  Debaryomyces ...
XP_011275006  542 shhg------------dsnadttaaDIEKLQreREAKAAAFALGGPRREESQqqntnssspddsfvqqgitpattfnekv 609 
CAR25108      572 ---------------------dATDIDAEATGTDAETEEGtieeplelvdvmdpseashtinrldaishgekvdteslgh 630 
Q6CQI7        572 -----------------ledpnSLEKQQQTSLNSSEAGQEppqrpvqssgitprp------------------------- 609  Kluyveromyces...
XP_001524316  584 ---------stnevkassssstESDQQEKRAGTTNEDSEEngd------------------------------------- 617 
CCE44430      582 ---------------stistssEPEVTAEVKNSSSSTEGE---------------------------------------- 606 
EGW30681      584 ---------------------tSEDTVEEKPSSPKEDTSVe--------------------------------------- 603 
EMG47527      582 ---------tttneikgsssssEEGGAAISSTTAEQGEVApqvfvspp-------------------------------- 620 
EER35378      590 ---------attnelknsssssEHDRVANEPAQPEfvispps-------------------------------------- 622 
EDK37276      479 ----------------seeslnSPETESPQTGIDEKDNDSvpsle----------------------------------- 507 
Q6BMF1        582 ----------vgidnskedfddSPGSSNSIEVVANEDQGRmvfa------------------------------------ 615  Debaryomyces ...
XP_011275006  610 pwptggndeeaqlngsdlynetTESDEKQQSSETSENNDG---------------------------------------- 649 
CAR25108      631 qsqkskpepspsnslegqspnqgttttsssnfdeekldreSQAASAASMdsyardleklRKDMEAKRDEEEGAVAYTEGN 710 
Q6CQI7        610 -------------------------tfadekipfpssqisGNSEAESGPrpggssesgsKTSEEFPLATDQANVAYQEGS 664  Kluyveromyces...
XP_001524316  618 -------------------------------------ggdEFITSPGILekqsgkskygLHPSRTKDRERIPTAAYQEGD 660 
CCE44430      607 -------------------------------------------HLLDPNektsgksqygQR---SRPEVPVPTSAYQEGD 640 
EGW30681      604 ---------------------------------------tEETMQGGVPdktsgmkkygQRPPTEEEKRSIPTVAYQDGD 644 
EMG47527      621 --------------------------------sptsdkiqLSSSPPTTPkktsglseygQKQPTKLEKAPVPTVAYQDGD 668 
EER35378      623 ----------------------------------psihepQVEEPEQIPkktsglskfgQRMPTKAEKAPVPKVAYQDGD 668 
EDK37276      508 -----------------------------------ventgEKIAIAVPHgsqqdaeadkVDHRTTERKQSVATVAYQEGN 552 
Q6BMF1        616 -------------------------------------vppYDSHGRVEQdedqdngkvsFARNAMEGRKSVPSTAFQEGE 658  Debaryomyces ...
XP_011275006  650 ------------------------------------------------------------AGGEDYERNRRPSAAYTEGD 669 
CAR25108      711 KIIVENKDGEIIdqaelN--RKPRDEEEGpdstt--------------------------pqdrkSRSRSYSINSLKR-- 760 
Q6CQI7        665 RIILENRKGEVVdeaqlVprEDVLNDHAEl----------------------------------sTTPTNHTINSLKR-- 708  Kluyveromyces...
XP_001524316  661 NLIVEDQHGEILdnlklNtlPVGQRKPVGkae------------------------------sknDDDSIHSMESLQR-- 708 
CCE44430      641 NIIIEDQFGEIMdnltlGkrGEAVEKRRKsqssnapvsspgvasvaaaaaaddaqhegddegaegDDESIHSMGSLER-- 718 
EGW30681      645 QIIIEDQYGEIMdslklQqrAKPAPVEPVesftn---------------------------inddDDASVHSEASLQR-- 695 
EMG47527      669 QVIIEDQYGEIMetlklTskPDRQKLEEMtgeaprp-----------------------prrhsaDSGSIHSMESLER-- 723 
EER35378      669 KVIIEDQYGEVMeilqlShkDDIKKLQGSrpssppav--------------------dtsarqsqDSDSIHSMESLER-- 726 
EDK37276      553 KIVIEDENGEVVetlpmKgnKAIAKAARGe-----------------------------------DNMSIHSAESLRR-- 595 
Q6BMF1        659 KIIIEDQAGEIIetlplKslQGQPENE--------------------------------------DDLSIHSMNSLSR-- 698  Debaryomyces ...
XP_011275006  670 KLIIEDQHGEILdqanmDvpDRLKKNDSSrssrsk------------------------ksstkrSKSPSSSINSLTRkt 725 
CAR25108      761 -----ALTPPrmrrq---------------------------------------------------tlvdeQANKRYFAY 784 
Q6CQI7        709 -----VLTPTrfrhs---------------------------------------------------tlvdtDTSKKFYAY 732  Kluyveromyces...
XP_001524316  709 -----RLSQYsiasdksresmkqdemragatsgatsgpekrkpsiaqsaashilpkikrtesrrtyykkddPKRRKVYAH 783 
CCE44430      719 -----QLSQYsngstiksgpsdsdttqdttggk----------------ksplhkrisrsasrrsyyrkddPHRRKVYAH 777 
EGW30681      696 -----RLSQYasadseysfndekqeqddtdls-----------------pirkrisrsiskktkvlyrkddPHRKKVYAH 753 
EMG47527      724 -----HLTQYstvssgtvdsevdekdhhlgl-------------------splqkklsrtlsrrsyykkgdPNKHKVYAH 779 
EER35378      727 -----HLTEYsnassgtekegessdadhlgl-------------------splqqkisrtlsrrsfykkddPHKRKVYAH 782 
EDK37276      596 -----QMTQYstasnssnqsrtqtlee---------------------------rlskvpsrrrafykkgdPGQRKVYAH 643 
Q6BMF1        699 -----QLSKYstaqsdrtstetslntkekpnsplg------------klarssslslgrkgkrkgyykkndPKHRKVFAH 761  Debaryomyces ...
XP_011275006  726 ssileRVNSGn------------------------------------------------------------RDRPKYTAY 745 
CAR25108      785 KIDDQLIIENDDGDVLRRYKInphaeagakpapkrkptgvv---------akalsavglskgssrapsenTSgsSAQGDV 855 
Q6CQI7        733 KYGTQLVIETDKGEIVRRYQInqhsspttesptttkprsnsv-------vakalsmvklgksstskqhpdSAqrPTSASS 805  Kluyveromyces...
XP_001524316  784 RIDNLILIENEDGDIIRRYKVnrhasnipkpnrsrsstl--------------vgkmksfvgmkdkeqqqQAlaSSLAGA 849 
CCE44430      778 RIDNIITIENEDGDIIRRYKVnrhvsnppnptpnrs-------------------rsstlvgkmkslvgmKPntTATATA 838 
EGW30681      754 QVDDLIVIENEEGEIIRRYKVnrhhskfrnppqeqeggt-------------rprsttlvgkmksilgfnESepTSPTTP 820 
EMG47527      780 RIDDLIVIENEDGDIMRRYKVnrhtgnptttpqqqqqqadpnqptsgnktrsrsgtlmgmmksivglkpsDKtkSASPET 859 
EER35378      783 RVDNLIVIENEDGEVIRRYKVnkhaadpaqqaaqsksra-------------rsgslmgmvksivgmksgNSnpSSPTAT 849 
EDK37276      644 QVDNLIIIENEDGDIVRRYRVnkhstnrersgsl-----------------------mnralskvgirsrQGstSAPEPV 700 
Q6BMF1        762 QVDNFIVIENADGDIIRRYKVnrhtanrarsntgn----------------------smvgkalnfvglkKNnpKNNVDA 819  Debaryomyces ...
XP_011275006  746 KLDNQLIIENEDGEILRRYKInhhktvqqktrsgs---------------------iaggfgkalsavgiKSniGANKDE 804 
CAR25108      856 AQpqssvakirdrrltpvpt------------------------------------------------------------ 875 
Q6CQI7        806 GSslnsrqnfknkviarqltp----------------------------------------------------------- 826  Kluyveromyces...
XP_001524316  850 NGelqqqhqqqqqqqptvhvtdlekgthhtilvpqddeknqhsphladgldkvedkiagilesrhqhgghelvrrasppp 929 
CCE44430      839 TTttntshtgastnqtptnpdevsqvhvtdlekgthhnilipeavrdphpds-------akldkiedkiatiletkhqtg 911 
EGW30681      821 TIqvsnydleqgnsnmiiphegdegdtkleh------------------------------------------------- 851 
EMG47527      860 SVpistlnsdleqgnsnpvlvadvgnqpldsrteqkledklanml--------------------tqksetgnkatvtrm 919 
EER35378      850 SPqtsatanfdlekgnmnrvllphneeelhehmgsklehkledklts----------------ilehgqdtgsksqptrk 913 
EDK37276      701 LTqvhdstkpnsplrdskletkienqlvdiftkkkg--------------------------------------pgqpkg 742 
Q6BMF1        820 NDlekndienilipehddtnnpnhplknpkfenaiesk-----------------------------------ltkilld 864  Debaryomyces ...
XP_011275006  805 SPldnsnteikdhlqlepleqpep-------------------------------------------------------- 828 
CAR25108      876 -----------sgamdvgssedeeeeseEDGSSDEESERAIDDEPEsASDYDGSEDGSYTdeg------fsdEEPETAIE 938 
Q6CQI7        827 ----------lpvvdhlseedddddnedDDDYSDEENS---------ENISSEEEDTSADdd--------eeEEDETEVE 879  Kluyveromyces...
XP_001524316  930 pihgdineegededgdvvddddengedsEEYDTDSDEEEEEEEEGG-DGHGELMDDEAESd------------eEETSVE 996 
CCE44430      912 hhsairkasppppppnrlgddavdeyddEDSTADEEEE----------------EDEDESd------------dEETEVE 963 
EGW30681      852 klsnmlskkksppprvlsdedeedsnesQDSEEDVSEV------------DSEVDSEEDSd------------eHETEVE 907 
EMG47527      920 ssppasqqqqqhpiveasdedlensdlsQDSEVED----------------------DDDd------------eEETEVE 965 
EER35378      914 asppppahrnnafddeeeeeeeedselsEDSEADE---------------------------------------EETEVE 954 
EDK37276      743 qaaiqrkrspppavaeatdededqedydHDSEDDDASV------------------DSEEde----------ilQESNVE 794 
Q6BMF1        865 drskssnflsvgnksetiqedsergvsdDDYDTSSGSE----------------ETDEDEdq----------vlEETDIE 918  Debaryomyces ...
XP_011275006  829 ------vranddsiheeadsdleeitsgEEESDSEE--------------VDSDEDSEESdddediaprpagFQEETAAE 888 
CAR25108      939 RARRLTALGHVSAp-rREDDEE 959 
Q6CQI7        880 RARRLTALGISTAp-rHQDDEE 900  Kluyveromyces lactis
XP_001524316  997 RARRLQALGRIPNrnrDEDDEE 1018
CCE44430      964 KQRRLQALGKLPNrnrDQNDEE 985 
EGW30681      908 KRRRLQALGKLPVh-rHQDDEE 928 
EMG47527      966 KRRRLQALGKLPTtrrHEDDEe 987 
EER35378      955 KRRRLQALGKLPTgrrNRDDEE 976 
EDK37276      795 RQRRLAALGRIPDk-rDRDDEE 815 
Q6BMF1        919 KKRRLAALGQMPTh-rRKEDEE 939  Debaryomyces hansenii
XP_011275006  889 RDRRLAAIGQVDAp-rDESDEE 909 
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