7SZC,4WW5,8K20


Conserved Protein Domain Family
CGI-121
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pfam08617: CGI-121 (This model is not part of the current CDD release)
Kinase binding protein CGI-121
CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.
Links
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Statistics
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PSSM-Id: 518382
Aligned: 143 rows
Threshold Bit Score: 54.0738
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7SZC_B        23 FKDVKNA--GDL-------RRKA--MEG-TidgSLINPTVIVDPFQILVAANKAVHLYK------LG---KMKTRT-LST 80  human
Q8I3Y9        20 FKNVVNS--KDLlesytksMNdnicy--indffLLLDSNLVYNENHILHSIYRAHHNF--------------QSKKrITK 81  Plasmodium falc...
XP_001329122  16 FENIGDP--QTI-------NDYIkanq---ppvALIDARTIISLAHVQVAILNMRTIQE-------------RDQT-QSK 69 
WP_013179548  19 ILGIKNAvvNNE-------IFQLnkk----fefQMINADYIATIEHIKHAILQAM-----------------TKKN-ISN 69  Methanococcus v...
Q18DI5        16 FVSIVDKieKGT-------GATI----------QAFDARYIVNQKHIKRAIECADRARR-------------RNNN-IAR 64  Haloquadratum w...
Q4DY70        12 YHDVRDA--ASL-------HEQFkkRSI-Sa--AVIDSAYIMSRLHLVVALHRISSAPLiighddCQpkmTRKSTArTAR 79  Trypanosoma cruzi
Q4UGL2        65 FNSIKTP--KSIldfn--------------vlfLVLRPSLILSVDHLLHSVARALTNVL-------------SSKP-VSS 114 Theileria annulata
XP_001019173  26 YEKISNP--LQV-------IELL--NSKna-nfTFLNAKLIVSLKEILIGLNRIY-----------TqqeNLTSKS---- 78  Tetrahymena the...
XP_034422320  20 FKNVTNS--KDVleiynkqSDDIsssdqqnkffLILDSQLVFNEGHILHSIYRGYHNF--------------KTKKkITK 83  Plasmodium berg...
XP_002259700  19 FKNVTNA--KELlrvynekTQAVdpdm--rrffLLLDGQLIFSDNHILHSLYRAYHNA--------------LTKKrVTR 80  Plasmodium know...

7SZC_B        81 ----EIIFNLSPNNNISEALKKFGIS--AN-DTSILIVYIEEG-------EKQINQEYLISQVE-G-HQV-SLk-----n 138 human
Q8I3Y9        82 niflEILFLLSPHENINECVKQYQIK--ND-SSSVIYVGINIS---------KDQVDMFIKSVQ-G-DQA-DFn-----e 141 Plasmodium falc...
XP_001329122  70 siylEILRCLSPDGRLNGALKFCAIQ--KD-TTAVIAITFEDEfpsipglSDPKTFDQFLANPK---------------- 130
WP_013179548  70 nfwvEILVRASATRQIATAIKLLGAK-----SGDVCLICNDEE-------TANIIIDKIGGIVQ-K-NSVeFLdvpndvn 135 Methanococcus v...
Q18DI5        65 drsiEMLLYAAGRRQITEALE-IGVS--SGlNRIVVAIDGGNE-------------IEAAKSIEsN-----TLdtpadev 123 Haloquadratum w...
Q4DY70        80 ----DVFAALSHTRNLYRVLEHLTCS--ET-TRAVVIVLSAPT---------EEDVAAVLDIVQgVrHGLlSLet----- 138 Trypanosoma cruzi
Q4UGL2       115 nfttEVAFMLSGSSSVGKSLERVLLSknDK-SSPALILTLSQN----------KSRDSILDIINgVqDDIsNLdky---- 179 Theileria annulata
XP_001019173  79 -----LIFYLSPESSKAPEIELFKVF--DFnQPSILVLQQLEG---------CNIFDELDANIK-G-NEL-PIs-----q 134 Tetrahymena the...
XP_034422320  84 niilEIFFLLSSHENINECINQYKMN--EN-STSIIYVGVNMP---------NDQMIEVTKIIQ-G-KSA-NFd-----e 143 Plasmodium berg...
XP_002259700  81 nivlEVFFFLSAHENINECLKQYQIR--DS-SSSVIYVGVNIP---------RDEVHSFTNLIC-G-QST-SVd-----d 140 Plasmodium know...

7SZC_B       139 LPEIMNITEVKKIYKLSs-qEESIGT-LLDAIICRMSTKD 176 human
Q8I3Y9       142 LSFLHDKKKILENFKCD------NMDnLERFIYHNIASKK 175 Plasmodium falciparum 3D7
XP_001329122 131 ----TDFDKIKKAFKLSd--AMLATYsHEQLVITTLSVLA 164
WP_013179548 136 NEK---FKKIVELYGLK---NVNSSKeLVKRVLEEIAIIE 169 Methanococcus voltae
Q18DI5       124 LGS-YDPDLVQPYFDITaneIDVVNGdTESLVLERVALLA 162 Haloquadratum walsbyi DSM 16790
Q4DY70       139 ---yRDEAAVREFYGVG----ESEAAaLEVTIVNRLATSD 171 Trypanosoma cruzi
Q4UGL2       180 ----tkVDDLTKEFKITq-eELKLPGgLEASILCRIGVKR 214 Theileria annulata
XP_001019173 135 IGSFIDLEQIKRLYGITe-qEADLETdIRGSIYNIISMKK 173 Tetrahymena thermophila SB210
XP_034422320 144 ISSLHCEKKILEHFNTD-------INnIDRFIYHNIASKK 176 Plasmodium berghei ANKA
XP_002259700 141 IRFLHDEKQIMQNFKCT-----GEVAnLERFIYHTIASKK 175 Plasmodium knowlesi strain H
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