Conserved Protein Domain Family
SPA

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pfam08616: SPA 
Stabilization of polarity axis
Yeast AFI1 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarisation-specific docking factor.
Statistics
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PSSM-Id: 400783
View PSSM: pfam08616
Aligned: 23 rows
Threshold Bit Score: 97.7453
Threshold Setting Gi: 229271741
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001643016  376 NQKILRFLSKFYPFINKL--TLQNFSWRLIINSTTFSKDELSHFILVLSNYVNScfdCDATTYykqnsiliFPY--MDIS 451  Vanderwaltozy...
Q55D43        566 DYKVIGLVQKFGNDVMKIf-NGVLSQKRIIFLGYGCGADEICNYVLAACSMVCPplkGTRERC--------FPN--INLH 634  Dictyostelium...
EEN42632      180 EADIFKCLHPVLPHVQMLw-ELVLTTEPIIVMAPSPTV--CSETVLALTSMISPlnfCSDF----------RPYftIHDS 246  Florida lancelet
CAR29254      269 DTKISKFLLNFIPLLHKRd-ANDSFHFKLVIYSSQYKGSGLSQFAIALSNLMGL---TNGTRSfsnkpcltLPF--VDVS 342  Zygosaccharom...
CAR24421      316 NDHVLKFLLKFIPQLDEL--PRSRFSWRLFVNSTKLPKDTLCQFILSLSNFIK----HFDFHYfenaqviiFPY--MDIS 387  Lachancea the...
Q75BQ9        342 KDHVLKFLRQFIPQISLL--DRNDPSWRLMVNSTTLSKDSLCQFVLALSNFINA---FDHQHYfqnssviiFPY--MDIS 414  Eremothecium ...
Q6CPS0        322 NNSILKLLARLIPLLTEI--PDSTYSWRLIINSTERSKDELCQFVLALSNLIN----GFSSEYfdnssiciFPY--MEIS 393  Kluyveromyces...
EFC35937      470 GTSLVQLVQYFGLETMLVcwNALLLDKRIMVIGSPAKL--VSQICLTLPLLIYPfqyn---------vnrvHPY--VPLS 536  Naegleria gru...
EFC40537      366 QTSLCRLVTNFKENTMLIf-NAILYQKRIVFFSGQQLAGQVVNTLLSSLVMFPFlhdLLKKRT--------FPY--ASFS 434  Naegleria gru...
XP_001467119  587 RYSLESLIETLGPSSLHLl-LGILTEKKILILSRKGEAADVCEAALSLGIIGNMldrDFMARKv-------FPY--VSVS 656  Leishmania in...
XP_001643016  452 M----VDALRKYLNdksgnisnkfAIIGVANPIF-----KYQQNL-WDCYYDLDTETLYDSI 503  Vanderwaltozyma polyspora DSM 7...
Q55D43        635 Hqi-lIDKLPPSTG----------VILGVSNPVF-----EERSEW-WDILCNIGTGKVILNP 679  Dictyostelium discoideum AX4
EEN42632      247 EfkeyTTKTQAAPP----------VVLGVTNPFF-----AKTLQH-WPHIIRIGE-MGNIGK 291  Florida lancelet
CAR29254      343 I----IGPLKEYLAlqdr---gifLIMGTTNPIF-----KSQDGL-YDYYYDLDNELISEAA 391  Zygosaccharomyces rouxii
CAR24421      388 F----LDALREQLVlqng--rrmfTIVGVSNPIF-----EYQKDV-WDFYYDMDAGSL--QT 435  Lachancea thermotolerans CBS 6340
Q75BQ9        415 M----IDELRNEFSvkkt--gnyfSIVGVSNPIF-----EMQKDV-WDFYYDLDSATLLTQA 464  Eremothecium gossypii
Q6CPS0        394 I----IDMFRENFTeeftk-gnffSVVGVSNPIF-----QYQVDA-WDFYYDLDSDSLLNSK 444  Kluyveromyces lactis
EFC35937      537 EmddvLSATSKIPE----------YIIGTTNALFetqgkNQRTQW-WDVCLSVNSRKVQLAE 587  Naegleria gruberi
EFC40537      435 N-----LEFLDVEG----------YIVGVCNPMF-----AQREEY-YDLLVDIDKMEVKVSQ 475  Naegleria gruberi
XP_001467119  657 S----VNYFMQVPG----------YIVGTLNPIF-----DNVNPWgWDLLCDLDNKSVITAA 699  Leishmania infantum JPCM5
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