5U0P


Conserved Protein Domain Family
Med20

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pfam08612: Med20 
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TATA-binding related factor (TRF) of subunit 20 of Mediator complex
This family of proteins is related to TATA-binding protein (TBP). TBP is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of the preinitiation complex. Human TRF has been shown to associate with an RNA polymerase II-SRB complex. This Med20 subunit of Mediator is found in the non-essential part of the head.
Statistics
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PSSM-Id: 400779
View PSSM: pfam08612
Aligned: 32 rows
Threshold Bit Score: 133.637
Threshold Setting Gi: 74851683
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U0P_T        14 MA----TFLSPAQDN---------LVRTYFAQHLKKWVVQYKLYRNAVT---------------------P-------KT 52  fission yeast
Q6CAY6         1 MVt---ILQYSADVTattistyrsELSAQLAQNLGKWSFELKMYKPNPAsigrsehhngnipqgqqeaaaAdqeiggvAA 77  Yarrowia lipoly...
EDK46012       1 MVsa-vILVQHATPEtiiq--fedQLSNELPTRRGNWGFTFKIFRNNLYsvpe-------------aiagThernptsQF 64  Lodderomyces el...
A3GGE8         1 MVsa-vLLIQKATPEtitq--fhdQLSNELPTLRGKWNFNFKIFRNNPYsipq-------------elaeTatvapesKW 64  Scheffersomyces...
EDK40006       8 RSvs-iILVSNATPDtilq--fhdQLSNELPVLKGNWNFSFKIFRNNPYsippekal------elsqsdeS-------KY 71  Meyerozyma guil...
Q6BXG1         1 MVsa-lILIQKATPEtivq--fhdQLSNELPTLKGKWSFSFKIFRNNPYsiapelae------tsvtsseS-------KF 64  Debaryomyces ha...
Q75F10         1 MKrtavIFIEKATPStitq--fhdILSTHVLAIQEKWSFELKTFRSSIKnlpp----------------------sdtKV 56  Eremothecium go...
Q6CTQ9         1 MTyygvLFVEKCTPStitq--lqdVLSTDLISMGDKWSFELKTFRTSAKntdp----------------------ndtKV 56  Kluyveromyces l...
XP_001645545   1 MVrtavIFLERATPGtlte--fkdALSNMLSSILDPWSVEFKTYRCSIKnlpe----------------------gssKV 56  Vanderwaltozyma...
EDN62279       1 MGksavIFVERATPAtlte--lkdALSNSILSVRDPWSIDFRTYRCSIKnlpa----------------------dvsKL 56  Saccharomyces c...
5U0P_T        53 LEFLKQNINPSMLACVDEAT----------------------------------MIDAEPELEDIIVRTK-LWNFRQSFT 97  fission yeast
Q6CAY6        78 LYTLTQAHSKGDMVYVTQgsavq---------------------------gqpgVVVSDSFDMVLQNKMKsIWILRQTLR 130 Yarrowia lipoly...
EDK46012      65 LFTLAPTYLPGSTITIINGHsagvfcnsiqeevielgnnpelsipdnhlhlgatTGLNDSFDLFLNQKLQsLWTQKQIIK 144 Lodderomyces el...
A3GGE8        65 LYTLSPSYLSDSSISLINGKsvgvftnlikeeagehghsvelsipnshlhkgatTDLNDPFDFFVAQKLQsLWTQRQLIR 144 Scheffersomyces...
EDK40006      72 LHTWSPSYLPGTGVALINKSsscvfsqviaeeagne--nveftipdahlhqgatTGLNDPFDYFVAQKLQsMWTQRQTVK 149 Meyerozyma guil...
Q6BXG1        65 LYTLAPSYLVGSCISLINKNsacvfsnvieeesaeisngsefsipdshlhqgatTGLNDTFDFFVNQKMQsLWTQKQNIK 144 Debaryomyces ha...
Q75F10        57 LYSLQLTHRDNQTVVIKNQSaivtgqhst----------------daltsngcsSGFPEPFDNILTSKLSnIWTQRQSTK 120 Eremothecium go...
Q6CTQ9        57 MHTVQLSHKNNETVTIKNQSaiitptyvt----------------kalydngcvFGTPEPFDYMLSNKLSnIWTQRQSIK 120 Kluyveromyces l...
XP_001645545  57 MHSVSFSHHDKRSILIQNKNaiittsnskdi-------------pnslifngcsTGTAEPIDSILSTKLSnIWSQRQGIR 123 Vanderwaltozyma...
EDN62279      57 MYSITFHHHGRQTVLIKDNSamvttaaaadv-------------ppalvfngssTGVPESIDTILSSKLSnIWMQRQLIK 123 Saccharomyces c...
5U0P_T        98 IEGSI-YEV-----GSFKVAIANVLQKSVWKGILFHVTYDG-------------TESVDLARPIIQEFFLKCFLQNNKSV 158 fission yeast
Q6CAY6       131 GDGAE-YELmgdayGRVKVRLANVFLQGTFRGLLFQYEYEG-------------DTLDDRQQQHLMEFIQSSGFPSSNLI 196 Yarrowia lipoly...
EDK46012     145 GDGGQiYELe---nGKVLIKTSNVFMHGSFKGLLVQIEVDDsyrkrggaisataVTEREEDANIIRQVLAKYNVPQGKIS 221 Lodderomyces el...
A3GGE8       145 GDGGRiYELe---nGNLTIRTSNVFLHGNFRGLLVQIEINQnl---------cnVDDVSSFASTFETIRNKYGIPAGDLS 212 Scheffersomyces...
EDK40006     150 GDGGEiYELe---nERVIIRTSNVFLHGVFKGLLIQIEIPS---------------ITTADATVFDPVIQRYRIPQGRIC 211 Meyerozyma guil...
Q6BXG1       145 GDGGQiYELe---nGSLIIRTSNVFLHGIFKGLLIQIEVENes----------sEHETSSLSEPFERVLSKYNIPRGKMS 211 Debaryomyces ha...
Q75F10       121 GNFGTtYKT-----SELIIRASNVFSSSGFKGLLLEIECTDpv----------sAEEFDRRVANIRAMLSEIDINDYKLN 185 Eremothecium go...
Q6CTQ9       121 GEFGVsYQT-----ADLSIRVNNAFSYSGFQGLILELESKSsd----------nLEAFEKNVERVRTMLSGMGLSDVRVS 185 Kluyveromyces l...
XP_001645545 124 GDAGEtLKT-----AELLVRAVNLFSSTGFKGLLIELESIEdi----------sEDEFMKSLQNIRSILNDINSKDFKVS 188 Vanderwaltozyma...
EDN62279     124 GDAGEtLIL-----DGLTVRLVNLFSSTGFKGLLIELQADE-------------AGEFETKIAGIEGHLAEIRAKDYKTS 185 Saccharomyces c...
5U0P_T       159 TpVYESFFNQPRHSLdSKLLLQlFKQRID 187 fission yeast
Q6CAY6       197 I-------GGNGSGL-VQTGTQ-FVEALA 216 Yarrowia lipolytica CLIB122
EDK46012     222 F---DVLDTAASDRY-GNLCLQ-YSRTLD 245 Lodderomyces elongisporus NRRL YB-4239
A3GGE8       213 C---EVLDPKRLDTY-ADLIYQ-YSKILN 236 Scheffersomyces stipitis CBS 6054
EDK40006     212 A---EVLDPNLLDKY-GDLCLQ-LAEILN 235 Meyerozyma guilliermondii ATCC 6260
Q6BXG1       212 C---NVLDSKLLDKY-GDLCLQ-YSEILN 235 Debaryomyces hansenii CBS767
Q75F10       186 K---DEMNEGKPVFL-CDLAYQ-YVKVLD 209 Eremothecium gossypii ATCC 10895
Q6CTQ9       186 S-DKSQGSKQEDSSL-FDLAAH-YLKVLG 211 Kluyveromyces lactis NRRL Y-1140
XP_001645545 189 T---DQLYPDKQNYL-GDLAYQ-YVRVLE 212 Vanderwaltozyma polyspora DSM 70294
EDN62279     186 S---DSLGPDTSNEI-CDLAYQ-YVRALE 209 Saccharomyces cerevisiae YJM789
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