Conserved Protein Domain Family
Fes1

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pfam08609: Fes1 
Nucleotide exchange factor Fes1
Fes1 is a cytosolic homolog of Sls1, an ER protein which has nucleotide exchange factor activity. Fes1 in yeast has been shown to bind to the molecular chaperone Hsp70 and has adenyl-nucleotide exchange factor activity.
Statistics
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PSSM-Id: 400776
View PSSM: pfam08609
Aligned: 102 rows
Threshold Bit Score: 46.836
Threshold Setting Gi: 162682772
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P0CN68         4 INELLRWSIANstapdtdASEQLQIRFNPnstqsgtstlhasdsgppdispastpgpvtpddgsslplppgtEVPVtkkE 83  Cryptococcus ne...
KRH75713       8 wDGLLKWSIah------sDGTRPTRNLSE--------------------------------------------------- 30  soybean
EMS58400      12 wNGLLKWSLah-----gsDGTNPPRALSE--------------------------------------------------- 35  Triticum urartu
XP_006650814  10 wNGLLKWSLah------gDGTTKPRALSE--------------------------------------------------- 32  malo sina
VDC62528       8 wdGLLKWSLsh------sDGASPSRPLSE--------------------------------------------------- 30  field mustard
XP_002876226   8 wDGLLKWSLsh------sDGSSSSSRISE--------------------------------------------------- 30  Arabidopsis lyr...
EDQ62463       8 wKGLLKWSIan------sDGTADPRELSE--------------------------------------------------- 30  Physcomitrella ...
EDQ69188       8 wKGLLKWSIah------sDGTQAPRQLSE--------------------------------------------------- 30  Physcomitrella ...
XP_001958338  13 LQNVLKYTVQH-----------HDKNGTE-------------------------------------------PKEN---E 35  Drosophila anan...
XP_002030318  13 LQNVLKYTVQH-----------HDPNPEA-------------------------------------------APKL---E 35  Drosophila sech...
P0CN68        84 DLTTEMLDLI---LG---KGDSITMKEKMAFATDE-------NNSVEDRVEALDDFEMLIELIDNANNM 139 Cryptococcus neoformans va...
KRH75713      31 ----EDRRWFmeaMQsqtIDVVKRMKEITLVMQTPeqvlkdqGVTPADIEDMLDELQEHVESIDMANDL 95  soybean
EMS58400      36 ----EDRKWFmeaMQantVDVVGRMKEIAQVMKTPddvlqshGVTPENIEDMLDELQEHVESIDMANDL 100 Triticum urartu
XP_006650814  33 ----EDKKWFmeaMQantIDVVKRMKEITQVMKTPddvlqsqGVTPENIEDMLDELQEHVESIDMANDL 97  malo sina
VDC62528      31 ----EDRQWFmeaMQghtIDSISRMKQISQIMKMPeqllesqGVTIDDLEGMLDELQEHVESIDLANDL 95  field mustard
XP_002876226  31 ----EDRQWFmeaMQahtIDSISRMKVISQIMKMPeqvleaqGITPDDLEGMLDELQEHVESIDLANDL 95  Arabidopsis lyrata subsp. ...
EDQ62463      31 ----QDRQFFaeaMQsqtVDVIKRMKEISMVMNLTvedletqGITVEELEGMLEELQEHVESIDMANDL 95  Physcomitrella patens
EDQ69188      31 ----EDKRFFaeaMEsqtVDIIKRMKEISMVMNMPsevlesqGVTVEELEELLEELQEHVESIDMANDL 95  Physcomitrella patens
XP_001958338  36 TPDVEKSKFLeeaLTamtTDASKELKAALIVLEDG-------ESSLDEKKDSFEVIRSHIDDLDNANSL 97  Drosophila ananassae
XP_002030318  36 TPDPERAQFLanaLNamtVDAAAALKAALVILNSE-------EASTDDQIESLDVIRSHIDDIDNAItl 97  Drosophila sechellia
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