Conserved Protein Domain Family
PAP1

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pfam08601: PAP1 
Transcription factor PAP1
The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression.
Statistics
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PSSM-Id: 369990
View PSSM: pfam08601
Aligned: 11 rows
Threshold Bit Score: 352.627
Threshold Setting Gi: 164426604
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGC49388      253 YRDNSLL-NGNDFSFQFPKF-GDLPGSHMF--GDGLPKAPSHQAKRGSasptilGYDYRTPatsvnsfksan---vasqp 325  Histoplasma c...
Q0CHW7        244 SRGTYGL-NNNDFMFDFPKF-GDLPGSHIFnnNNQLQKMNQNKPQEGQspt-arRSDSNVPgvlnrdslnta---rnagl 317  Aspergillus t...
Q4WMH0        244 SKGMYGL-NNNEFMFDFPKF-GDLPGSHLFt-NTQTSKSNQNKAKDnpt--atpRSEAQVPgvlnrndlk-------iss 311  Aspergillus f...
Q5AW17        240 ANRMSGL-NNNDFMFDFPKF-GDLPGGRIF--NGSVAKTNQNK-----------KDDTPIPgilrhsalqaangrasssa 304  Aspergillus n...
EPS28318      240 SQGAYGL-QNSEFLFDFPKF-GDLPGSHLF--NGQSNKNDQTQNR---------NQPSRAPgvlardalgg------isa 300  Penicillium o...
GAD97460      616 SRNVSGL-SN-DFYFDFPKF-GDLPGAHIFn-NGSLAKANQNASKENGsaarsaSEFRAAPgvlgrdslgp------asv 685  Byssochlamys ...
Q0UPL8        244 FSSMLSTgNNNNFSFEFPKF-GGLPGAQLLdnGPLSSKNKNVSAAPNAsgrnnsVAQGVSP------------------- 303  Parastagonosp...
EMD97914      246 FSSMLNT-SVNNFSFDFPRF-GGLPGAQLLdnSSL-TKNKNASVSSSVsgrhnsTGRDLSP------------------- 303  Bipolaris may...
XP_012746955  244 SQAPHNP-NDVNFSFEFPKF-GQLPGPPVL------SKPSKSTTSPGE-------------------------------- 283  Pseudogymnoas...
XP_957544     232 NSFVSNL-NDVNFQFEFPKFgGPLPGPQSA------NQTKKGTPV----------------------------------- 269  Neurospora cr...
XP_003001831  106 ASALGNL-NDVNFQFEFPKF-GVLPGPPVA------TKASPQNSTASV-------------------------------- 145  Verticillium ...
EGC49388      326 qnfnlgNTPqFVRTPDSMHSADTAKSQRRnttgiening--sfdnypgrpSRNNTGLS-----------YARSG-Tnsnn 391  Histoplasma c...
Q0CHW7        318 splktnSPA-ATSVPSTRGTPITSQGSTR---------------------SPALPKPL-----------YHRAA-T---- 359  Aspergillus t...
Q4WMH0        312 pnglsnGPSpAKSTPSGQ-TP-NSQTSTRp-------------------gSGTLNGAV-----------DNNGA-Argyq 358  Aspergillus f...
Q5AW17        305 spktvtSNNpATKSPVTADGRLTSHTSSVynyh----------------------------------------------- 337  Aspergillus n...
EPS28318      301 aptvksTTNtDTTGPGSVNSYYAGSAGTTp-------------------sSVHSSRTT-----------YNsyk------ 344  Penicillium o...
GAD97460      686 ngasqsSTAaARTPADKVNGTYASGAEQSn-------------------nTAAGAAPA-----------RQNTV-Gsqg- 733  Byssochlamys ...
Q0UPL8        304 ------ATQaNGSWTNSPDAISASPVTNGtqrnnsvngfagynnaankntN------------------RGSSE-Ssstv 358  Parastagonosp...
EMD97914      304 ------NSNaNGSTTDSPAPMSAGA---KtqrsgslngffgfnnnnnnnnSTPNAGAS-----------RSNTT-Sstgs 362  Bipolaris may...
XP_012746955  284 ------APSrSTSFTSNLSPLDSGSRNSLsfgsnqnlantnqsnnnysgnGAALEGMTngnfdymvhhnKGSTSaSsads 357  Pseudogymnoas...
XP_957544     270 ------SPPlSSTGRLEQPTNGVSTGTTPnygqigldtq-tkedlahysaDLFTPQSA-----------RGEGAnFstrg 331  Neurospora cr...
XP_003001831  146 ------SPHqSSARKPMSPPQSKSSSESPlgvgsdlnal--pkddissfsSFFNPAIT-----------RGSMStSrasv 206  Verticillium ...
EGC49388      392 yat--yqiqnyGSSna-snSASPSASSESQ--H-LSSIGTSPEPSVSSPSIGKla-----esGLNTi--nEQNGNHPEGE 458  Histoplasma c...
Q0CHW7        360 -----------STNda-snSDSPSSSSDSHqsQlLSSSGTSPEPSTNSPANKP---------QDNH----HHTCTYNTID 414  Aspergillus t...
Q4WMH0        359 vnssysastkqATHdt-psSDSPSSSSDSHqsQlLSSNGTSPEPSLHSPAVKA---------TESSt---PHACTYTTIN 425  Aspergillus f...
Q5AW17        338 --------qpgQGHdt-stSDSPSSSSDSH--QfLSSSGTSPEPSVQSPDNQA---------KESHe---GHTC---TID 391  Aspergillus n...
EPS28318      345 --------tasASHreastSDSPSSSSDSHqsQlLSSNGTSPEPSLSSP-LQT---------KPSDn---INACEIHGSN 403  Penicillium o...
GAD97460      734 --------qapISStv-snSDSPYSSSESHqgRlLSSSGTSPEPSSNSPGGKPnd-----qgQQDSk---EHECG-GTID 795  Byssochlamys ...
Q0UPL8        359 qsrvfqfnsgsSTH-----SGSPASSTSPTggQ-DSSCGTSPEPSHTSPGQPRds-------------iaEGYVCHGNSE 419  Parastagonosp...
EMD97914      363 qsrifqfnsgsSNH-----SDSPSNSSTSPtnQ-NSSCGTSPEPSHASPNQQAdt-------------itDGYVCHGNSE 423  Bipolaris may...
XP_012746955  358 gsgptstghntSHS-------SPTSSNSHHg--tSSSCDTSPEPYTQSPPASKtaaaaaaaaTTTLstigEESHADPAID 428  Pseudogymnoas...
XP_957544     332 tdsqynagagtSTS-------SPSSCASNMggA-SSSCGTSPEPLTHSPVGLKs--------VDTMatigEEQPG-VIGS 394  Neurospora cr...
XP_003001831  207 dsnpysfnngtATS-------SPSSSTQSNagP-SSSCGTSPEPFTQSPMGFKp--------VETMttigEEQTALTTGQ 270  Verticillium ...
EGC49388      459 GEKSFYEKLGRACGCAENPVPAALSDS--NRLPKLPDHNNhnnntnnssnnninfpgDGL---LGIDWLAQQNGGQFDPV 533  Histoplasma c...
Q0CHW7        415 GQESFCAQLGLACGNINNPIPAVRNKS--PSVSNTPGQAGe---------------aEQF---PGLDSLAQQNGGQFDPV 474  Aspergillus t...
Q4WMH0        426 GEESFCAQLSMACGNINNPIPAVRQNS--ESASNTPSHANs---------------sDKA---LGLDFFAQQNGGQFDPV 485  Aspergillus f...
Q5AW17        392 GEKSFCAQLGMACGNINNPIPAVRQRS--ESATNTPNAPSs---------------tDNV---PGIDFMAQQNGGQFDPL 451  Aspergillus n...
EPS28318      404 GEESFCAKLGMACGNINNPIPAARDESkpKSVSSDQSETAp---------------aQDQ---VAFDWLAHQNGGQFDPV 465  Penicillium o...
GAD97460      796 GEKTFCEKLGLACGNIKNPIPPAMNGT--NRLSRTPGQSQp---------------sSDQqhpLGLDWLSQQNGGQFDPV 858  Byssochlamys ...
Q0UPL8        420 GEVLFCEKLNMACGNPRNPVPRAMSKSddKPPPVITATKSptpq----------------pqaNGLDYFANQNGGQFDPT 483  Parastagonosp...
EMD97914      424 ------------VLSAKSPTPAV----------------------------------------SGIDYLANQNGGQFDPT 451  Bipolaris may...
XP_012746955  429 SQSSFYSKLSQVCGSASQPIPRTMTSPplAPSTTAPTPAS-----------------NSSfdiNSLDWLAAQNGNQFDPQ 491  Pseudogymnoas...
XP_957544     395 GQPDF----------------------------------------------------NTFgvdNTLNWLPQDN-FQFDPQ 421  Neurospora cr...
XP_003001831  271 NSNSSNSNLGH----------------------------------------------FASvenSSFDWLAQQNGGQFDPQ 304  Verticillium ...
EGC49388      534 LFGDYRDPQDAVLSQ-DF-GNFFNDAL--PFPEFGGSLDS--LNELSNGnaTttlspttpQKH--DLLKQIDNVVEg-kD 604  Histoplasma c...
Q0CHW7        475 LFGDWREPQDAILSQ-DF-GTFFDDAF--PLPDLGSPSHN--FSELGHQ--Q--------PKK--DLISLIDDKLD---E 533  Aspergillus t...
Q4WMH0        486 LFGDWREPQDAILSQ-DF-GTFFDDAF--PLPDLGSPSHN--FSEATKQpaA--------PKK--DLIAEIDSKLD---E 546  Aspergillus f...
Q5AW17        452 LFGDWREPQDAVLSQ-DF-NTFFDDAF--PLPDLGSPSHN--LTEVGLGa-Q--------QKK--SILEEMDNK-----E 509  Aspergillus n...
EPS28318      466 LFGDWREPQDAVLSQ-DF-GSFFNDAF--PLPDLGSPSHN--ITEVSTQpnQq------pPKK--DLIAQIDSKLE---E 528  Penicillium o...
GAD97460      859 LFGDYRDPQEAVLSQ-DF-GNFFNDAF--PLPDLGSPFHN--FPDVASPpaTa-------PKK--DLITEIDNKLD---E 920  Byssochlamys ...
Q0UPL8        484 LFGEYRDTTNAIVGDgDFtGGFFNDAF--LNTGYASPFHFgdTPAVQKS----------------NPLEEIERIQD---G 542  Parastagonosp...
EMD97914      452 LFGEYRDTQNAIVGDgDFtGGFFNDAF--LNTGYASPFHFgdTPAVQKP----------------NPLEEIERAQDgqdG 513  Bipolaris may...
XP_012746955  492 LFGDYREPHDNILTG-LYdDSFFTEAFaiPGEFSGSPFTLdaTPQSQQTqqTtqqqhhqgGKK--DLIGEIDAQL----G 564  Pseudogymnoas...
XP_957544     422 LFGDYREPQNNVLNN-GFdDWLTNDAF---DADFLAPYNL--PPTAPGLlpPqpeaesqpPKK--DLIAQIDEVNA---S 490  Neurospora cr...
XP_003001831  305 LFGDYRETQTTVLPTaTFdDSFFNDAL---DTDFFMPYNMapSPAV--------------PKKsnNLIDQIDAANN---A 364  Verticillium ...
EGC49388      605 DeEVVPAEDPSQMLSCTKIW-------------------DRLQSMEKFRNGEIDVDSLCSELRTKARCSEGGVVVKQDDV 665  Histoplasma c...
Q0CHW7        534 D-EVVPGEDKTQMLSCTKIW-------------------DRLQSMEKFRNGEIDVDNLCSELRTKARCSEGGVVVNQKDV 593  Aspergillus t...
Q4WMH0        547 DeEVVPGEDKSQMLTCNKIW-------------------DRLQSMEKFRNGEIDVDNLCSELRTKARCSEGGVVVNQKDV 607  Aspergillus f...
Q5AW17        510 EeEVVPGEDKAQMLSCTKIW-------------------DRLQSMEKFRNGEIDVDNLCSELRTKARCSEGGVVVNQRDV 570  Aspergillus n...
EPS28318      529 --EVVPGEDKTQMLTCTKIW-------------------DRLQSMEKFRNGEIDVDNLCSELRTKARCSEGGVVVNQRDV 587  Penicillium o...
GAD97460      921 DdEVVPGEDKSQMMTCTKIWygsltdigaahshlptmyrDRLQSMEKFRNGEIDVDSLCTELRTKARCSEGGVVVNQRDV 1000 Byssochlamys ...
Q0UPL8        543 EdEVVPGDDINSMLNCHKIW-------------------DKLSSRPDFKDGTIDIDNLCSELRAKARCSESGVVVDHKDV 603  Parastagonosp...
EMD97914      514 DdEVVPGEDVNSLLNCHKIW-------------------DKLSSRPDFKDGTIDIDSLCSELRAKARCSESGVVVDHKDV 574  Bipolaris may...
XP_012746955  565 EeEVVPAA--SEMLTCTNMW-------------------EQIQACPAVQNGEIDMDSLCSQLQQKAKCSGEGPVIQETDF 623  Pseudogymnoas...
XP_957544     491 DdGV------REQLDCSKIW-------------------DKLRSCSSVQNQEIDMDALCSDLQKKAKCSGYGAVVDEKEF 545  Neurospora cr...
XP_003001831  365 DdELAKPDQIETNYGCTKVW-------------------ERLQNCPKVQNGEFDLDDLCSELQKKAKCSGQGPVVSETDF 425  Verticillium ...
EGC49388      666 EAIISR 671  Histoplasma capsulatum H88
Q0CHW7        594 DDIMGR 599  Aspergillus terreus NIH2624
Q4WMH0        608 EDIMGR 613  Aspergillus fumigatus
Q5AW17        571 DDIIGR 576  Aspergillus nidulans FGSC A4
EPS28318      588 DDIMGR 593  Penicillium oxalicum 114-2
GAD97460     1001 EDIMGR 1006 Byssochlamys spectabilis No. 5
Q0UPL8        604 EAALKR 609  Parastagonospora nodorum SN15
EMD97914      575 EEALKR 580  Bipolaris maydis C5
XP_012746955  624 KDVLDT 629  Pseudogymnoascus destructans 20631-21
XP_957544     546 KSVLKK 551  Neurospora crassa OR74A
XP_003001831  426 QKVVQK 431  Verticillium alfalfae VaMs.102
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