2OAJ


Conserved Protein Domain Family
Lgl_C

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pfam08596: Lgl_C 
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Lethal giant larvae(Lgl) like, C-terminal
The Lethal giant larvae (Lgl) tumor suppressor family is conserved from yeast to mammals. The Lgl family functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface. The N-terminal half of Lgl members contains WD40 repeats (see pfam00400), while the C-terminal half appears specific to the family.
Statistics
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PSSM-Id: 400768
View PSSM: pfam08596
Aligned: 13 rows
Threshold Bit Score: 412.5
Threshold Setting Gi: 74685309
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2OAJ_A        488 ELAVDKISFAAETLELAVSIETGDVVLFKYEV--------------NQFYSveNRPESGDLEMNFRRFSLNNT-NGVLVD 552  baker's yeast
Q6BJ57        555 CIDIVSVSLGLQNKEMAVGMGNGDVVICKFGK--------------VNIPP--NKGSSSGIDYHNCQVQHSNS-DAKIYN 617  Debaryomyces ...
Q6FMT9        549 NLSISDISFATDTLELSVATETGVVALFKFEV--------------NQFYDpeHKNKDRDMEMRFRRFSIGSS-KEMLID 613  [Candida] gla...
P38163        514 NLAIKNISFASETLELAVSSEVGDVILFKFET--------------NKFYG--QLPKSDALQLKFSRFSLDDS-KTILVD 576  Saccharomyces...
Q6C8J6        528 GVPVSKVSFAGQNAELAVAVSTGHVLLYKFDV--------------NKNPK-------PGLD-RMKDLNLSES-KEKVID 584  Yarrowia lipo...
Q59RK1        558 SLRVIFVSCAFENRELLVALATGEVVVCKFGK--------------NNR----NAGLSATKDYSDCAVQHANK-NAKLLD 618  Candida albicans
Q5KHB4        799 KVRIKSVHLAREALECVITFTTGEVLVTKFQKaktstdddryqeilNRGGDqvGEETEGSYFPPQPRQQGKSEwVEEVLE 878  Cryptococcus ...
XP_011395295  507 gVETTAMHMAQETGEFAAGTKTGEVIVWRWGI--------------NKNFG---KEAPRAEECE----------RGGLMD 559  Neurospora cr...
Q4WXX6        515 NVEVTEMSVSGSTGELSVGLKSGEVVVFRWGS--------------NGNFG---HEEPPGTNAG----------AGKLTR 567  Aspergillus f...
XP_662494     848 vVDVTEMSLGGSSGELSVGLRSGEVAIFRWGS--------------NQNFG---LEQPPGTNNG----------PGELTD 900  Aspergillus n...
Q10408        524 SAFITTASFSTYNPEFSCADSFGRVIVCKRKN--------------HKENL-----------------------PAQLAN 566  Schizosacchar...
Q75BT1        511 NVAVEHVSFAAETAELAVSVSSGDVLLYKFQD--------------NPMFN--PNGVAGELDGSFARLGIGNM-SELLVD 573  Eremothecium ...
Q6CPA2        491 SVAVDHISYAAETAELAVSIESGDVVLYKFQV--------------NQFFT---SQKDVALEMNFRRFSLNDKpHEILVD 553  Kluyveromyces...
2OAJ_A        553 VRDRAPTGVRQG--FMPSTAVHAN-KGKTSAINNSNIGFVGIAYAAGSLMLIDR-RGPAIIYM-ENIRE----------I 617  baker's yeast
Q6BJ57        618 IKDRVVGTFARSsnFLPVSLLKLDnQDQISCLKMSNIGFAAIGYKSGKMVVCDIsRGPAIIYNiDSIKKh--------lI 689  Debaryomyces ...
Q6FMT9        614 VRDRSPETVRQG--FMPSTVVNAQ-HGPTSALTNSNIGFVAIAYEDGTFVVVDR-RGPAIIYM-QNVRG----------L 678  [Candida] gla...
P38163        577 VSDRGPTNVKQG--FIPSTVIHAK-KGAVSAIMNSNIGFVAVGFIEGTLIILDR-RGPAIIFN-ENIRV----------I 641  Saccharomyces...
Q6C8J6        585 IRHRFTPGLKEG--FMPISLVNMN-YGNITALDHSNVGFVAIGYENGRVVIVDR-RGPAIIYD-EPCSQnsgggvfrsrG 659  Yarrowia lipo...
Q59RK1        619 ISGRVSGSLNASstFLPTSLLQIEpPEPISVIKMSNVGFGAIGYKSGRLVVCDItRGPAVILNlENIKEh--------lV 690  Candida albicans
Q5KHB4        879 IGHLAKPN-TDG--FKPVAIFTTK-QGEPISCAVSDIGFIAVAFSSKSLAIIDM-RGPDVILR-EGFDEdgammkkkkkK 952  Cryptococcus ...
XP_011395295  560 ISSRAEPSLKEG--LQPFVMHNMA-QGRVTVVAVSDVGFVAAGSEGGQLSIIDL-RGPKVIYH-GSVTEwskgekrglfK 634  Neurospora cr...
Q4WXX6        568 ITHRADPGLKQG--MLPLTLLNMQ-QGPVTAVKHSHVGFVAAGFQNGSFVIMDL-RGPAVIHT-AQVSDfaktskrgsfL 642  Aspergillus f...
XP_662494     901 ITHRTDPSLKHG--LLPLTLLSMQ-QGPVTALKHSPIGFVAAGFEGGSIAIIDL-RGPAIIHT-ANISElskqnkrssfL 975  Aspergillus n...
Q10408        567 GIYRLDDTLVLEgtLHAQYYIDLK-RGRVTLNQMSNIGFVCIGYQDGGITIIDM-RGPHILCN-TSISE----------L 633  Schizosacchar...
Q75BT1        574 VSDRAPSHMKVG--FCPLSAVRAN-LGKVSAVTNSNIGFVAVAYEDGSLLVIDR-RKPAVIYM-ENLRR----------- 637  Eremothecium ...
Q6CPA2        554 IRDRAPNNIREG--FMPVTAVHAR-KGRVSSLCNSNVGFVAIAYEDGTIIVIDR-RGPAMIYM-DSISK----------I 618  Kluyveromyces...
2OAJ_A        618 SGAQSACVTC------IEFVIMEYGDDGYSSILMVCGTDM-GEVITYKILPASGGKFDVQLMDITn----------VTSK 680  baker's yeast
Q6BJ57        690 TTESNCYITT------MEFAIMEYGQDGYSSVILLCGTNGgGNLMVFKIIPQGNGGFEVVFMNKTtnlnyrvlggeDAAD 763  Debaryomyces ...
Q6FMT9        679 PGIKGRKFTA------IEFAIMEYGDDGYSSILILCGTDV-GELVTLKILPDSGGRFVVEFVEIKq----------TNDK 741  [Candida] gla...
P38163        642 SKAGSSYVST------VHFCVMEYGDDGFSSILMLCGTDI-GELMTFKILPATNGRFEVKFTDATk----------TNNQ 704  Saccharomyces...
Q6C8J6        660 SGVGSAHVTR------FEFSICCIDDDEFSSIVLFAGTSN-GELITYRFVPNGRGGYKVEYVNRL-----------RICD 721  Yarrowia lipo...
Q59RK1        691 SVQGNCYPTS------IEFSIQEYGNDGYSSIVLLVGTNCgGNLVTFRITPMGNGGFEVVFADKTahlnyrttdasGAEG 764  Candida albicans
Q5KHB4        953 GNIQNVLPETsvv-gsLKWTVSGMGGDMVNRPRLIVSYVK-GLTKIYALI-NVLGEWVVEAKPPT-----------FTND 1018 Cryptococcus ...
XP_011395295  635 HSSSSSHGGKpewptvIEFGVMTLEGENYSSICCFVGTNM-GRVATFKLLP-SGQGYSVQLAGVA------------NMD 700  Neurospora cr...
Q4WXX6        643 KHRATESTAPewp-tsIEFGVLTLEGEDYSSICCFVGTNR-GNLATFKILPGDDGAYMGQFAGVT------------QLD 708  Aspergillus f...
XP_662494     976 KTRSSSETIPevp-taIEFGILTLEGEEFSSICCFVGTNR-GNLATFKILPSSGGAFVASFAGAV------------ALE 1041 Aspergillus n...
Q10408        634 GLERRGKPDPdfl-tsAEFVVMNPKGSP-SSIYVVTGTYR-GMTLLFRIDPSSSGRFSAYFESSR-----------QLDI 699  Schizosacchar...
Q75BT1        638 LKLKSAYVKS------IEFSIMAFRDDGYSSILLFCGTDA-GELLIFKVLPELSGRFVVNFVDNLs----------LHDQ 700  Eremothecium ...
Q6CPA2        619 SKVRSSYVSQ------FEFTIMEYGEDGYSSILLLCGTDA-GEVILLKIIPDPSGRFTVQPYDALk----------ATDD 681  Kluyveromyces...
2OAJ_A        681 GPIHKIDAF------SKETKSSCLATIPKMQ-----NLSKGLCIPGIVLITGFDDIRLITLGKSKSTHKGF-KYPLAATG 748  baker's yeast
Q6BJ57        764 SKLDKLIPI------NSSNGESAVANMEMFQ-----KLSHGIVIPGMIITTSNRDIRVLQLPKTKLSHKVVdESCLACGV 832  Debaryomyces ...
Q6FMT9        742 SPILKIDTF------EKKTTESCFATISKMQ-----DLGKGVVINGMVVVTSETDIRFVDPGKSKEGHKSF-KHKIATSG 809  [Candida] gla...
P38163        705 GKILGINSF------AKDTGYSCSATISKMQ-----GLSKGIAIPGFVTISGANDIRLVSPGKSKDTHALF-KYPIATSG 772  Saccharomyces...
Q6C8J6        722 DRILAINAI------DAERGSAALAFPHIMA-----KLGQDVLIPGTVVVTSVHDVRVIRPSASKMTHKKFpQYSILGGS 790  Yarrowia lipo...
Q59RK1        765 SCISQIIPI------NSVTGESAVANMSTFN-----KLSQGIVIPAYVIATSDREIRVLKLPKQKLSHKVVeDFCLKCSV 833  Candida albicans
Q5KHB4       1019 SLFGPIASFvldpmtGNELATSATALQAAMQeptdyGKGKEASVHCLWIAASKKSIRCAINFSGERIAKVElEDEELSNV 1098 Cryptococcus ...
XP_011395295  701 DKVVAICPI------EVQTGREAGATGPIVA-----GLREGKQVDGVLVAVTQTESKIFRPPHARGASKSF-DSGILCDA 768  Neurospora cr...
Q4WXX6        709 DKVLNIIPI------DADQGTPALATASIVA-----GLRTGAKVNGVVIAVTVSGCRIFKPATSKGAHKSW-DD-YLCDA 775  Aspergillus f...
XP_662494    1042 DKIINIIPI------NADDGSLALATGKAFG-----GLRNGTRVHGAVVAVTVNSCRIFKPATSKGAHRSW-DD-YLCDS 1108 Aspergillus n...
Q10408        700 KNIYKICSL-------TQDGQIATATGSSLQ-----SVGYPLPQEVFLVYIGDSGISVFNKINNQVGNLDW-RKPVCCRA 766  Schizosacchar...
Q75BT1        701 SPILKVETL------SIEHASSCQASIGKMQ-----ELKTGTIIRGCVVLTSGSGIQLITDWAVKPTCKSF-SVPLATTG 768  Eremothecium ...
Q6CPA2        682 GPIVSLATF------SKESGSSCRASIPRMQ-----QLSKGLRVQAQIVISGRTDIRLITPGKSKDTHRIF-KYPIAVSG 749  Kluyveromyces...
2OAJ_A        749 LSYistveknndRKNLTVIITLEINGHLRVFTIPDFKEQMSEHIP--------FPIAAKYITESSV-LRNGD-IAIRVSE 818  baker's yeast
Q6BJ57        833 IKV---------KDKGIVLASLVKLGFIKFSSIPSLNDIADVKIPkeiynklkNALESPISSQSDI-LITGE-MFVRLGP 901  Debaryomyces ...
Q6FMT9        810 ISHitfinavgqKQSLCVLIVLESNGTVKIFTTPDMKELKSMQLP--------FPIQAQYIRESSV-LRNGD-IMTRTGK 879  [Candida] gla...
P38163        773 LSFipiidgkgeRKLSTIMIVLLINGDIKVLTVPELKEVKNLRCP--------VPLSAQYVENSSI-LENGD-IVIRTGK 842  Saccharomyces...
Q6C8J6        791 ICFl-------rEGDSMALVCITDTSELVCLALPSLREMSVKKLP--------YRIDPRTGVNSVF-SLTGD-IIIQIDR 853  Yarrowia lipo...
Q59RK1        834 VNY---------HNKGIVLAILVKSGFVKLCSLPSLSDIANVKLPkevyaqvkESLESGMATQSDL-LRSGE-LFVRYSK 902  Candida albicans
Q5KHB4       1099 FYVt--------RHGHKIIIAVTTTGSALVYTVPFLQYITRINLF--------FGPQGRSSGKLSIdDRSGD-FVEYSGP 1161 Cryptococcus ...
XP_011395295  769 AAVtpad--tsmSSHGYALVAVFNDRTLRSYTLPGLREIAKHPL---------PMLDPLRTISTVI-SKTGD-VLGFTGP 835  Neurospora cr...
Q4WXX6        776 AAVvkt------egRGYSLVGLFGDGNARAFSIPGLKEIGCTSIH--------QIADMRRLSDSTV-CPDGS-VLTWTGP 839  Aspergillus f...
XP_662494    1109 ASVvnl------pgRGCSLVGLFGDGNARAFSIPGLKEIGCAKIG--------HMADMSRLSQSTV-SPNGS-VLFWTSP 1172 Aspergillus n...
Q10408        767 ALVls-----tvSKHMGSVVCVNSDLSVNWYSLPNLREERKMQLP--------LDIDKNRLKEGDI-LGNGDyIFPTLGA 832  Schizosacchar...
Q75BT1        769 CAFvpykgakdqLLTGIILIALQINSEIKLLSLPDLKELKTLVPP--------TTPQAQYLRNSSV-LHNGD-LMLRVGP 838  Eremothecium ...
Q6CPA2        750 LSIvpflnakneHSIATVLVTVLINGEIKVLSLPELKEIKSFAPL--------ANVHSKYVKESGV-LVNGD-IVYRVSK 819  Kluyveromyces...
2OAJ_A        819 FQASLFSTVKEQDT------------------------LAPVSDTLYINGIRIPYRPQ---VNSLQWARG-TVYCTPAQL 870  baker's yeast
Q6BJ57        902 TEGINLSAYISESKekk-------------------lkEPHATDLLFNENAIIPPRPA---AGAIQWAKGqTRYISNEDL 959  Debaryomyces ...
Q6FMT9        880 FQSYLFSTFDQRAIglnka---------------ytqeQVEKQDTLYNPGLKIPWRPQ---VNSLQLARG-TSYCTREQL 940  [Candida] gla...
P38163        843 FQASLISVLNESATgtnht---------------adisQHTPIDTLYNPDLKIGYRPQ---VNSLQWARG-TIYCTPYQL 903  Saccharomyces...
Q6C8J6        854 HEAGLISVFGKGVKf-----------------------EDIPGDLLYDPLKVCPPRPV---VSTLQWVRG-SVYTTKEDI 906  Yarrowia lipo...
Q59RK1        903 TESVYITTNEKTRHk-----------------------DDTNTDRLFNENAIIPPRPT---ASTLSWAKGqISYVSVDDL 956  Candida albicans
Q5KHB4       1162 LDINLRTFFHFRKP-------------------------LPPRIDPCAHKKAIPPQPQpvnAGVISWIWG--ATLTGAQL 1214 Cryptococcus ...
XP_011395295  836 SEITVLPVWGGSGRa-----------------------LENTLDTMINMAQELPPRPT---ISNVQWLSG-TQYISPTDL 888  Neurospora cr...
Q4WXX6        840 SEVAVFSVWGS-GTglygplsldpvfvqrkerpankhdRRSSDCRLFNPQAAIPARPT---ITNLQWISG-TQYVSPADM 914  Aspergillus f...
XP_662494    1173 SEIGLINVWGAGIE------------------------LRPSEDQLFNPQAVSPPRPT---ITNLQWISG-TQYISTADM 1224 Aspergillus n...
Q10408        833 HELAFGCVLGSGRTl----------------------aNLAPMMLITHNASHVPPRPS---KSLWNWLLG-EQSTSAEEL 886  Schizosacchar...
Q75BT1        839 AEAILFSILPGQSQdnt-------------------saADAETDVLYNPKLHFPARPH---VGALQWARG-SMLVKCDEL 895  Eremothecium ...
Q6CPA2        820 TEAFLLTVIKKSSTtsq-------------------sqNSEETDSLYNPNLRIKCRPY---YNSLQWVRG-SIYCKPEDL 876  Kluyveromyces...
2OAJ_A        871 NELLGGVNR-PASK 883  baker's yeast
Q6BJ57        960 IGLIAGPNR-RSTK 972  Debaryomyces hansenii
Q6FMT9        941 DLLLGGERR-PQSK 953  [Candida] glabrata
P38163        904 DELLGGIER-PESK 916  Saccharomyces cerevisiae S288C
Q6C8J6        907 DKLIGGARR-PKSQ 919  Yarrowia lipolytica
Q59RK1        957 AMLVAGPNR-KPPK 969  Candida albicans
Q5KHB4       1215 DALIGGPLRaPPPK 1228 Cryptococcus neoformans
XP_011395295  889 DLLIGGPDR-PPSK 901  Neurospora crassa OR74A
Q4WXX6        915 DLLIGGPDR-PPSK 927  Aspergillus fumigatus
XP_662494    1225 DILIGGPDR-PPSK 1237 Aspergillus nidulans FGSC A4
Q10408        887 DILLGGENR-AESK 899  Schizosaccharomyces pombe 972h-
Q75BT1        896 AELLSGGNR-PPPK 908  Eremothecium gossypii
Q6CPA2        877 DHLL-GEGR-PEQK 888  Kluyveromyces lactis
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