Conserved Protein Domain Family
Duc1

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pfam08588: Duc1 (This model is not part of the current CDD release)
Domain of unknown function at the cortex 1 (Duc1)
This entry represents the Duc1 (Domain of Unknown Function at the Cortex 1) protein, which is involved in maintaining proper plasma membrane lipid composition and cytokinetic ring anchoring in Schizosaccharomyces pombe. Duc1 localizes to the plasma membrane, except at the cell division site, and its localization is controlled by interactions with the ER-PM contact site proteins Scs2 and Scs22 through a FFAT-like motif. Duc1 promotes proper localization of the PI-5 kinase Its3, thereby maintaining appropriate levels of PI(4,5)P2 at the plasma membrane. This function is important for proper anchoring of the cytokinetic ring during cell division. Duc1 contains a conserved domain previously known as the DUF1769 domain of unknown function.
Statistics
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PSSM-Id: 518360
Aligned: 338 rows
Threshold Bit Score: 50.9402
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OAQ27264       2 ALTIRVGps---rqQESLKPCSINRDSEP-------VYIs-SEHFEGLIT----VRIQHhhpatssssspiNKSASTCAY 66 
THU75592      14 NFLTISR-------SRKVVLARSESSSTPt------KLS----NFRPRTD------SRE--------------------- 49 
KDQ13356       4 RIALTVGps----pSQLKPMYPNDGKWVP-------VVGp---NFEGRVAvhanGHVDE------------NGNTFQSPY 57 
XP_001418798 108 PLHMTIPsy---agCKITRGALTYNSEIPf------EFE--TSVFAGRCL----IRFRDcpppp--aaaapDAARRLEEY 170
XP_003080562 167 PIHMTTPsy---arCEITKGEMTYNDDVPf------QFE--TPVFKGKCL----CRFRDcdppp---satgRTMRWLDAY 228
XP_002504706 340 GGRGDAGggggagsKAPSKVPSPVDTCCPvntetwmNFE--SELFVGKIV----CRFKGigcp-----anpAAVKTKEDF 408
XP_007510193 256 EENEEEGeea-yaeWNELTDTCPVNTETAl------EFE--TDIFKGKVV----CRFLG------------MEGETPEQF 310
KOO25316     221 LLRLACG--------AEPYRTVGFNDPSS-------VFPieTEYFVGKGY----VRLRS-------------LPGEPTEY 268
XP_002289523  15 NLPCDAHnd----eEPVLLNSLPIDGTVV-------QFN--GPNFDGKLV----SRVRDsptaa--anvqeRKLMSNNEY 75 
KAG8462874   102 MLRIASGv-----hEGQQVEFNLPSSVFPv------ETE----LFEGKMY----FRLRG------------CAHEPKDYF 150 Diacronema lutheri
OAQ27264      67 Fe---nHSRV-------FSLQWQGRFkatNPWSKdglwdADEVLFVAEVeGKihvP--------M-GT---SIATAFAR- 123
THU75592      50 ------RSSA-------ISKDLK--M-------------GKRVSISRERiEKg-----------------lLGAYRYKA- 83 
KDQ13356      58 FelgedKDRKnv----sWSVQAQGRV---LQPIS-----VDDLLVGVVF-EE---Pl------nL-PWg-vLPLISFLSr 113
XP_001418798 171 Fr---gRART-------FQCVVQGKF---KRRIR-----ADETVTGHEF-FQ---Pll----giPgKRf-vKTLVHILRa 223
XP_003080562 229 Fr---gKKRT-------FQYVVQGRF---KQSVR-----VDRVFTGHEF-RK---Plv----giPgKFl-iKAMLRVVRv 281
XP_002504706 409 F-----KTQKrc----tFQVLVQGRF---KERVR-----ASEIQTGGEF-GK---Pfq----dvPpHYl-iKAGCKFFQa 462
XP_007510193 311 Y-----IERGqicnniaFQVVVQGEF---KERIR-----MDQVVTGGEF-KR---PfenipprtIvy--tgQELFKVIT- 370
KOO25316     269 Fk---gKARQ-------MSTVIQGHF---KKPLP-----AHELATGFEF-DH---Plq----nlPaRTv-lRILLSLIRq 321
XP_002289523  76 Fq---gRSRQ-------FQWTVQGRF---SRRMR-----FDEVTTGQEF-GR---Pfr----ntPsSKm-vKRGLDLLKh 128
KAG8462874   151 Fg----KQRR-------LSAVVQGRF---KERLV-----MGECYTGYEF-RA---Pfk----nvP-APfliRTGLSFIRt 202 Diacronema lutheri
OAQ27264     124 ---TIdP--SF-IADgiWDPk---RPWVGSPLVSGMN-VLRVwkapllptsdsappttatairisrgtgsgsgdcssten 193
THU75592      84 ---ID-P--TL-THD--LASpt--kPWALSPLISTML-HFAHt------------------------------------- 114
KDQ13356     114 ---LN-PqlKE------GASea--rPWVTAPLLSTATyASHI-------------------------------------- 143
XP_001418798 224 --mN--P--SLrMSL--FAR----KPQVWTFLGASAQ-VISI-------------------------------------- 252
XP_003080562 282 --mN--P--SLtANI--FAN----HPQLWSSLAGSAQ-TISV-------------------------------------- 310
XP_002504706 463 --lT--P--GLeIDL--LCD----EPYYMALLGGTVT-TLAI-------------------------------------- 491
XP_007510193 371 ------P--GL------ACDvtanEPYYLALLGGLVS-QMSV-------------------------------------- 397
KOO25316     322 --iA--PaaSF--DL--LGD----KPVVLNPLFETVQ-RLHV-------------------------------------- 350
XP_002289523 129 klpE-----TFeCDF--FSD----EPRFEHPLLAGCN-HFRV-------------------------------------- 158
KAG8462874   203 ---La-P--TLvEDI--LGDr----PYFLNPLCQTIQ-VMHV-------------------------------------- 231 Diacronema lutheri
OAQ27264     194 qdRGGDGNGEGRENgvgpw------iyhgVHRLEEGHvdllseagarrqqlqvsstvstasmdSITTPPSKATTAtgqqk 267
THU75592     115 --RLVSLTDNLDTP---------------ACSPVDSD------------------------------------------- 134
KDQ13356     144 --RHPETEPLPPAPpldkpiregihtlvqSHISSPAE-----------------------------LQQFDRPRK----- 187
XP_001418798 253 --DTPGDEPDITRG---------------SFEENNSKf------------------------gGAFASGRLTSAQ----- 286
XP_003080562 311 --DDPGGEPDIASA---------------DFVENTHRfg-----------------------gAFARRRHVSCKK----- 345
XP_002504706 492 --DETEDAAADPLT---------------DVAEDNGR---------------------------MFGGESYSVSR----- 522
XP_007510193 398 --DTKETVPNILDFmip---------ehcDIVEGNDGf------------------------fQGVKHLNMQARG----- 437
KOO25316     351 --ARPGDEPEITKV----------------FEEDNALl------------------------gGAFAKWPIGWKE----- 383
XP_002289523 159 --DIPEDFEGVSESd-------------iHGIGDDGNvied-------------------ttlLDDAAIPSDGVS----- 199
KAG8462874   232 --SEPGSEPSITDA----------------LHESNARl------------------------gGIFAERRCDRIK----- 264 Diacronema lutheri
OAQ27264     268 lqgltsyqRRRY--Ft-kTEHRQAaVLAPDL-VIAGDFF--NN------FT----NFETRrv-smGI-------SIRMDR 323
THU75592     135 --------VPEFp-----SNQ----SLTNDTsPLHL--AivSP------TS-----LSSS-----IP-------DSPPSS 172
KDQ13356     188 --------RRAY--FanlANRSSM-VITPSD-VLSMELC--YGrv---tFP----DLRLR-----LPfg----iTLDLLK 237
XP_001418798 287 --------RRRLla---dVKKAKQySFSTDD-VYTFDFY--QHvfdpktFTlnilGLDAF--------------RVDVAR 338
XP_003080562 346 --------RRRL--LsnpKHASRH-EFRPEH-VYTFDFY--QH------FFkp-drYVVD-----VPgilgrsrVIDVAE 399
XP_002504706 523 --------RSRT--LgnpDTAAEY-WYNTSD-VYTFDYF--QSvllfdeYC-----LDIG-----IV-------KLRLDR 571
XP_007510193 438 --------SRRVkeLanpATAKKY-YYEPGL-IYTF-----DNmqsylhLD----SYSFD-----VGkv----lTLKLER 489
KOO25316     384 --------RKRL--FvsrTPAGGPyMIDPAL-VYTMELY--EDklcpstYE-----LAIG-----MF-------RYSLGR 433
XP_002289523 200 --------RRKY--FaknCNLEKY-YYEPEL-LYTFDFya--------nFF-----SPMRhrlelTPf-----fSIDLIP 249
KAG8462874   265 --------RKNY--FasaANGRQH-AFEPSL-VYTMEFYedKFdp---aYF----DLMIIg------------lRFNLNR 313 Diacronema lutheri
OAQ27264     324 V-LqDD--QPLRFI--------CKSRRRH---LEKQKQEYGLG 352
THU75592     173 A-FsSS--SSLSFLssrkqqqqQSIPLNK---DALTVVAVHIR 209
KDQ13356     238 L-T-GN--QRARTMl------cRRNANGGrpkDEDILFCWEMH 270
XP_001418798 339 H-V-GD--QPPQIM--------ARTSRPG---EYLFCFCMWHE 366
XP_003080562 400 H-T-DG--EPAQIM--------ARDRSTG-----HYLFCFALW 425
XP_002504706 572 H-L-NG--NPICIM--------AKHVDGR------YVYNFEIF 596
XP_007510193 490 H-L-NG--QPIQFF--------AKTGDGR------YAFCFEMW 514
KOO25316     434 IlV-GGtkKPQCVT--------SMGQVGFqphSRQYIFNIEMW 467
XP_002289523 250 Y-F-NG--YPL-FMs------mARDKNSG---QYLWATELWHK 278
KAG8462874   314 Y-L-GA--QPLQIM--------GKHGAVPhggRSLFNVEMWHE 344 Diacronema lutheri
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