6AHR


Conserved Protein Domain Family
Ribonuc_P_40
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pfam08584: Ribonuc_P_40 (This model is not part of the current CDD release)
Ribonuclease P 40kDa (Rpp40) subunit
The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex.
Links
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Statistics
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PSSM-Id: 518357
Aligned: 45 rows
Threshold Bit Score: 193.31
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6AHR_L        76 ELITPEFISTFIKKGSCYALTyNTHIDEDNTVALLPnGKLILSLDKDTYEETGLQGHPSQFSgRK--IMKFIVSIDLMEL 153 human
Q6C7H2        66 redgSSFSASVFQKSDAWIIS-KSRIDSDNVFAVWR-GNVHMSLTRSTYQTSGLNGKKSRYGd------KYLISFNLRNP 137 Yarrowia lipoly...
EFQ85767      86 EIIESDFMNGYIKQGNIMMLS-EGRPLLDDRFELYE-GILRMELTRPTYERCGLQGSPVEDGgRKhqKQRWIVEYDLRAN 163
EPS33562      82 DLLEHEFFNTYIKTGNVMMIS-EGQAGSDTLFTLND-GILRIELGREKFERVGLSGKPVRSGgRKhtKERFLIELNLRLP 159
XP_002341661  83 TLLEGDFFNDFVKPGSVLILS-EGRPGVDDVFSLEQ-GILTLQMSRDKYERTGLTGKPIRSGgRKheKERFAIEIDLRQP 160
Q5B728       103 SLIEGDFFNTNIKSGNILMIS-EGRSGLDNVFTLRE-GVLKLELGKEDYEKTGLTGKPVRTGgKKhgKERFVIELNLRLP 180 Aspergillus nid...
Q0CT78        83 SLLDGDFFNTYIKSGDVLMIS-EGQSGSDNVFTLRD-GVLRLELGKEIFERTGLTGRPIRSGgRKhaKERYLVELNLRLP 160 Aspergillus ter...
XP_001272075  83 ALLEGEFFNTYIKSGNVLMIS-EGRSGSDNVFTLRD-GILRLELGKEIYERTGLTGKPIRSGgRKhaKERYLIELNLRLP 160
Q4WQB1        69 ALLEGDFFNTYIKAGNILMIS-EGRSGSDNIYTLKD-GILRLELGKEVYERTGLTGKPIRSGgRKhaKERYLVEINLRLP 146 Aspergillus fum...
XP_001239226  83 DILDGEFFNKYIKTGNILMIS-EGQSGVDNVYSLRD-GILRLELDKSSYERAGLVGKSVRSGgKKhvASRYVVEINLRLP 160

6AHR_L       154 SLNLDSKKYERISWSFKEKKpLKFDFLLAWHKTGSE---------ESTMMSYfskyqiqehqpkvALSTLRDLQCPVL-- 222 human
Q6C7H2       138 NFHIGTKQHNRFLFGLEQLDkLHPDLEYSVTVHANDaryvseylsNVKEVPLk------------TTVSERNVLVPSMtp 205 Yarrowia lipoly...
EFQ85767     164 SMKHGKGRFSRLEWACKNVLdKSLTWLF-YNFNPSSaes-----ltEGKEPIskhqpwih-eirpnatiMEKLLVPRVsl 236
EPS33562     160 SMLHGKKGFDRIVWAFKNVLdRSVAWLF-CDLDSISspq--------asNPIekqspqwi-tpemaktsLNRVSMPPLe- 228
XP_002341661 161 SMLHGKKGFERIIWACRNVLnASVTWLLICDAVSQNsld-------kaAAALqkyqpril-dcefeeiaHPVVRVPPLsm 232
Q5B728       181 SMLHGKKGFQRVEWAFKNVLnQPTTWLF-FDLGTEStgv---aegGPGDPTLkgnnpeli-pcepvlttYDNVVTPSFs- 254 Aspergillus nid...
Q0CT78       161 SMLHGKKGFERIAWAFKNVLnHSVAWLF-YDLSPTSngi------sqDDTELkgnhphii-dtevvttrRANMLVPSFde 232 Aspergillus ter...
XP_001272075 161 SMLHGKKGFDRIVWAFKNVLdQSVAWLF-YDLTSGVqgi------snGDLLLkgnhphii-dcevmrteHRNVLTPSFne 232
Q4WQB1       147 SMLHGKKGFDRIVWAFKNVLdHSVAWLF-HDLAPGFtgi------seGDPTLkgnhpqii-dcvvsrthYRDIITPSFse 218 Aspergillus fum...
XP_001239226 161 SMLHGKKGFERIVWAFKNVLnESLTWLF-SDLSPSSdls-------gqDAPIkrhspqif-sctstksrFQNVLTPSFtp 231

6AHR_L       223 --------------QSSelegTP-EVSCRALELFDWLGAVFSnvDLNNe---PNNFISTY---C-CPEPSTVVA---KAY 277 human
Q6C7H2       206 pvvpeltdahsgakVDVsqkyRDhLFESWALGLQEWVGLASIgaGRIAsddnVNNLFSQYqveDgQPA---------NVT 276 Yarrowia lipoly...
EFQ85767     237 ------------sdPTSlyaeED------ALGLLEYFRMVQLksPRIEkgddINPHLSRY---E-VP-DFGKGVslrNMV 293
EPS33562     229 -------------gLVSsqmaED-EMQQNCGALSEWIGLTQMrsPRISaddqIDPYLSRY---E-VP-GTEVCKt-vDLV 288
XP_002341661 233 ------------deVRSqsslAA--LEDYCNEVSEWLGLVSLqsPRISvddvIDPYLSRY---A-VPQSESTQLqstALV 294
Q5B728       255 -------------eLNAmtqsEP-DLRDICGEVSEWLAMVSIrsRRVSatdsIDPYLCRY---V-APEISGKAAiatDLI 316 Aspergillus nid...
Q0CT78       233 ------------lnITDrtphED--LKESCEELSEWLGMMALgsPRILedddTDPFLCRY---S-VPGREGSVQs-lNLV 293 Aspergillus ter...
XP_001272075 233 ------------kdFTea-psED-LLKDKCEDLSEWLAMVALdsPRVSkdddIDPYLSRY---S-VP-DNEDRNs-tDLV 292
Q4WQB1       219 ------------ttLTea-ssES-ILKEDSQNLSEWLAMVALgsPRVSkddeIDPYLSRY---R-VP-DDGPVRt-vDLV 278 Aspergillus fum...
XP_001239226 232 ------------stFQAeseqAIsELSDTCVEIQEWLALAFLgtPRLNaddsIDPYLSRY---S-VP-NKENCTs-sNLV 293

6AHR_L       278 LCTITGFILPEKICLLLEHLCHYFDEPKLa------------------------PWVTLSVQGFADSPVSWEKNEHGFRK 333 human
Q6C7H2       277 NIQVVGM------CPLLASKLKILGEQTNa------------------------PFFAFTVYGVQDTPYSWDNKEHQYDN 326 Yarrowia lipoly...
EFQ85767     294 VVHWIGLISPAFIRDLFLIVRRDGF--KGkrkanstqdedvsmegsslvdekdeeWFAMSAQAFG--------------- 356
EPS33562     289 SLKWHGLIPAKWILDLYACLLSNGPKASHgsdln---------------skllsSWFVLAASTLRTQAVE---------- 343
XP_002341661 295 ILRWQGVMGSRWINQLLVSYLL-----QRelrt-----------------drlsVWSALSASAFPRVAVE---------- 342
Q5B728       317 SLKWGGLIPPHWITQLFITLFRKSAPRFCkt----------------------pAWFALSANTLGRDAIE---------- 364 Aspergillus nid...
Q0CT78       294 RLKWHGLIPPKWIMQLFITLSRETLSAPAd-----------------------rAWFALTSNALGRDAVE---------- 340 Aspergillus ter...
XP_001272075 293 SMQWKAFIPPSWILALFTTLLRETASKTSpa----------------------sTWFALSSGALGREAIE---------- 340
Q4WQB1       279 SLTWHGFLPASWILDLFITMLRETASKSSpa----------------------sTWFALSSSALGREAVE---------- 326 Aspergillus fum...
XP_001239226 294 KLTWKGLLPSHWITQLLIATLRSTAgs--------------------------dSWFAISSHALGKEAVE---------- 337

6AHR_L       334 GGEHLYNFVI 343 human
Q6C7H2       327 GGENDYTIID 336 Yarrowia lipolytica
EFQ85767     357 -GKHAWTVMQ 365
EPS33562     344 -GKDGFTIVT 352
XP_002341661 343 -NKDGYTILS 351
Q5B728       365 -SKDGYTIMA 373 Aspergillus nidulans
Q0CT78       341 -GKDGYTIMA 349 Aspergillus terreus NIH2624
XP_001272075 341 -AKDGYTILL 349
Q4WQB1       327 -AKDGYAIML 335 Aspergillus fumigatus
XP_001239226 338 -GKDGYMILa 346
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