6QW6


Conserved Protein Domain Family
PRP3

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pfam08572: PRP3 (This model is not part of the current CDD release)
pre-mRNA processing factor 3 domain
This domain is found in U4/U6 and U4/U5/U6-small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. The pre-mRNA processing factor 3 (PRP3) domain, responsible for the binding to stem II of the snRNA duplex, is highly conserved among eukaryotes and is found N-terminal to pfam06544. The human PRP3 has been implicated in autosomal retinitis pigmentosa.
Statistics
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PSSM-Id: 518351
Aligned: 108 rows
Threshold Bit Score: 88.4179
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QW6_4A      308 NTFFD----------PRVSiapsQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEIs---------QAARKT------ 362 human
XP_001643871  39 NPYLStnnqspnssyRKVH----ERYRKGLKFFQKGEISAKYELERKVKADEEARQQEederkrikeeEEQEILkvkvan 114
XP_003958609  35 NPYLAtsak-----------nstPYRHKLLRFHKPGEVSAIIERQREERKTEDIKRRQdalrlqeldkKRNEEEklkils 103
XP_003679017  43 NPYLStstl---rsnDKVT----KRLERGLKFHEKGEVSSQIERQREEQRLEYERQKEqeilnkirreKEQAETsakiar 115
XP_003671523  68 NPYLStfntq-pstkTRKG----QRIQ---TFFQPGEVSKRIQHERELQRKVLEQERKfnelerqrrtKEDEVTklkiqn 139
XP_003673750  74 NPYLStlnkh-tgyeNKIH----KRYQRGLSFFQKGEISSKISDERQVQREELERNRQfnerekirleKEDKKRrikier 148
XP_056087093  68 NPYLSdiqg--pspsNKLN----RRYERGLKFYKKGEISKRIAQERELRKFQEDEDSKrrl----kleEEEREReklves 137
XP_004180844  44 NPYLQdsss--kfvdYKLQ----RRFDRGLKFFKKGEKLNEIAKKRKIIHDSIEKNKLelqlqnelerKRLNDLrtkien 117
Q6FJ58        41 NPYLSdig----qqnGKVF----KKYKDGLRFYKKGEISAQLHKEREELARRLKEEELraaaekahrvSLAEQKrerian 112 [Candida] glabrata
XP_002555281  45 NPYLSrerf--dtvaSKVS----KRYSRGLKFRTPGVLAKELDEKRAwlake-----------relqkEQDNLRkakvra 107
6QW6_4A      363 GIHTSTRLAliapkkelkEgDIPEI------EWWDSYIIPNGf-DLTEE-NPKRED----------------YF------ 412 human
XP_001643871 115 GELPDFSTGenkylkdltN-IPT-V------EWWDKPYLd-----DRLEiFDKYRVpcregdn--tdeeeeeDEdfde-- 177
XP_003958609 104 GELPDLSIGedkflknsnD-IPDTV------EWWDKIYLd-----QTFNiLQKYEDetyn--------sddeDEdd---- 159
XP_003679017 116 GELPDTKVGedkyirrieD-VPE-V------EWWDKPYLd-----DQLNvLPKYQGgyee--------esesDEed---- 170
XP_003671523 140 CELPDLALGedkyipnvdD-IPD-C------EWWDVVYLd---tTDKTKiLDKYSMqypsvee---dedfvsDEedee-- 203
XP_003673750 149 GELPDLELGedkyilkasS-VPT-V------EWWDLPFLe----EKSLQiLDKYSMpypnd------edfisDEgdve-- 208
XP_056087093 138 GHLPDLKLHedtyildlpK-FETYYnanhghEWWDTVYLd-----EKGEvMEKYRMkgtspaeedgkydnddDDdddd-- 209
XP_004180844 118 AELPDQTKNeekylksieT-IPK-V------EWWDEPYLNETsnSDTLTlVDKYRNdysnln-----edddsDEdded-- 182
Q6FJ58       113 AEIPDDSIGeelymqrfkD-IPN-Y------EWWDESYLd-----KSGNiLPKYTTeypedmds-dydsddmNSgvecmk 178 [Candida] glabrata
XP_002555281 108 GELPDESIGeqny--litD-VPQ-I------EWWDAIYVq---sPEDWTiKTKYSKsygtm------dedsdDEqdse-- 166
6QW6_4A      413 --------GITNLVEHPAQLNPPVDNDTpv-----tlG-VYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRI 478 human
XP_001643871 178 -----nmkPSIRYVLHPIPIKV-D---Evv-----pvSkVYLTKTEIKKARRNRRKIEREELETKIKLGVLPKPAPKVKL 243
XP_003958609 160 ------etPSISYVQHPIPIKVH----Dir-----vpSkVYLTKKEQKKLRREKRKLKREEIETKIKLGLQPKPEPKVKV 224
XP_003679017 171 ------evPSIQYVHHPVPIKVH----Npk-----ptTkVYLTKKEQKKIRRNKRKFEREEKETRIKMGLDPKPEPKVKL 235
XP_003671523 204 -----erhPSIRYIQHPVPIKM-ELSNQgg-----rpNkVYLTKKEQKKIRRNKRKLIRQEIDEKIKLGLEPKPVPKVKL 272
XP_003673750 209 -----eihPSIRYIQHPVPIKV-E---Evk-----ikDkIYLTKKEQKKVRRNTRKLIRQEKEEKIKLGLEPKPLPKVKL 274
XP_056087093 210 -----dkhPSIRYVAHPIPEKI-N---Yak-----vsVkTYLTQRERKKIRRNRRKMFREAQEVKIKLGLLPKPEPKVKL 275
XP_004180844 183 -----glhPSLRFIQHPVPIAAKA---NstsessvviPkLYLTKLETKKLRRNNRKLIREEKESRIKSGLDPKPDPKVKL 254
Q6FJ58       179 sqteetgpPSIRYVQHPVPIKI-P---Eei-----taPkMYLTKLEHKKARRRNRKLQREEKMAKVQLGLEPKPETKVKL 249 [Candida] glabrata
XP_002555281 167 -----sesPSVRYVQHPVPVQAAE---Hap-----skPkIYLVKREQKKIRRNRRKLLQEEHEQKIKLGLEPKPAPKVKL 233
6QW6_4A      479 SNLMRVL-GTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLT 521 human
XP_001643871 244 ANMMSVYeNNQNITDPTSWEKTVRNQVEERKRKHEDMNLQRHEE 287
XP_003958609 225 SNMMNVLeSNQNITDPTSWEKTVKEQQEERKRKHYEMNEKRHEE 268
XP_003679017 236 SNMMSVYeNNQNITDPTQWEHTVIEQVEQRKRKHLETNMIRHEE 279
XP_003671523 273 SNMMNVYeNNQNITDPTSWEVTVKQQMEERKRKHEEINQKRHEE 316
XP_003673750 275 SNMMNVFeNNQNITDPTTWETTVKQQVNARMRKHEEENNERHEl 318
XP_056087093 276 SNMMSVYeNDQNIADPTAWEKTVKDQVDLRKRKHMEENERRHEE 319
XP_004180844 255 SNMMAVFeNNQNITDPTAWENTVKTQINDRKQKHLQENEKRHLE 298
Q6FJ58       250 SNMMNVLdNNKNISDPTAWENMVKDQIEERRQRHIQENEKRHEE 293 [Candida] glabrata
XP_002555281 234 SNMMSVYqNNENITDPTSWEQTVKAQAEERHQKHVETNIRRHYE 277
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