4F52


Conserved Protein Domain Family
Kinetochor_Ybp2

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pfam08568: Kinetochor_Ybp2 
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Uncharacterized protein family, YAP/Alf4/glomulin
This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS). The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12.
Statistics
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PSSM-Id: 400745
View PSSM: pfam08568
Aligned: 28 rows
Threshold Bit Score: 270.122
Threshold Setting Gi: 45476903
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4F52_E     3 M------------------------------------------------AVEELQSiikrcqILEEQdfKEEDFGLFQLA 34  human
Q7JRC9     1 M-------------------------------------------------QEQEME------VEVGDpaKASNLLRLIKQ 25  fruit fly
Q5U3W2     1 M------------------------------------------------ALDQLSDmvqrcqTVKDEsfSPEDYDLFTAA 32  zebrafish
Q6PCE9     1 M------------------------------------------------AAADLQSitekfqNLSEDdfKEEDTNVFLVT 32  African clawed frog
CAK48534   1 MallpvspsgclflpprvsavpprpaaispagwpslpshsftpsctsdlAMAAEED------PLIQAlpPATDYLTYLTL 74  Aspergillus niger
Q0CVJ5     1 M--------------------------------------------------AESED------PLVQAlpPATDYLTYLTL 24  Aspergillus terreus...
Q2UAW5     1 M--------------------------------------------------AEEED------PIVQAlpPATDYLTYLTL 24  Aspergillus oryzae
Q7RZR9     1 M------------------------------------------------DSEKAIA------AIKEArpPATDRFTYLTI 26  Neurospora crassa
EDN95705   1 Me-----------------------------------------------PRIDPVV------DIKANapPVGDHLAYLNF 27  Sclerotinia sclerot...
Q76PC4     1 M------------------------------------------------DWKEAIP------GAAKVaiETKDYITYSTL 26  Schizosaccharomyces...
4F52_E    35 GQRCIE----------EGHTDQLLEII-QnEkNKVIIKNMGWNLVGPVVRCLLCKDK---EDSKRKVYFLIFDLLVKLCN 100 human
Q7JRC9    26 LLLek----------aYDGVRMLFQSAqEsEkNTRLLPHIAMDLYHDVCLENISDEVnsqEPELFDCSDELLKLLAKYAP 95  fruit fly
Q5U3W2    33 GSTCIE----------QGDSAQVLSILvD-EkNQNIVRCMGWNLLGPLVKMLLKKE-----DKTLPHCHAILLHLLEVCS 96  zebrafish
Q6PCE9    33 CQKCLE----------EEEVALLLEIIrD-EkNQAIVKNMGWNLIGPITKCILRSSN----NDTSKICLDMIHYLCMLCN 97  African clawed frog
CAK48534  75 LEYql----------tPARLPILHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------DCLHDIARLGN 127 Aspergillus niger
Q0CVJ5    25 LEYql----------tPARLPVLHKLL-Q-D--ETLTTNIGWDLVQMLLPMLPQSS-------------ECLQDIARLGN 77  Aspergillus terreus...
Q2UAW5    25 LEYql----------tPARLPTLHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------ECLQDIARLGN 77  Aspergillus oryzae
Q7RZR9    27 VETnl----------sPAVLPTLNEVL-Q-D--AELTQEIGWDLVYNLV-NLPGSD-------------ECLETIARLGN 78  Neurospora crassa
EDN95705  28 ITKVLIddqpa-vdlrLELLSSLNDVL-Q-D--KERANLIGWDIMPTLL-RVPGSE-------------SCLITIARLAN 88  Sclerotinia sclerot...
Q76PC4    27 LELILEearikdideqRELIKCLHEELkQ-EkNDHITREISWDIIGMVLPYVGKVQNe--AD-------EFVDFLAKNGN 96  Schizosaccharomyces...
4F52_E   101 PKELLLGLLELIEEPSG--------------------------------------------KQISQSILL-----LLQPL 131 human
Q7JRC9    96 LHELMLELMERLEESSS-----------------------------------------------INVFGA-----YLRAL 123 fruit fly
Q5U3W2    97 PKELLVGLLEQVEEADS--------------------------------------------GFIAETITL-----LLKPL 127 zebrafish
Q6PCE9    98 PKEVLLGLLEQIDEAAG--------------------------------------------EQISQVVLL-----LLQPL 128 African clawed frog
CAK48534 128 PREVILRVSDALMQLQPededddsddgtak------------------adeapqdatdggsKNAALPRHIlqfntLVSML 189 Aspergillus niger
Q0CVJ5    78 PREVILRVSDALMQLQPeded----------------------------------------------------------- 98  Aspergillus terreus...
Q2UAW5    78 PREVILRVSEALMQLQPededdddddddeenetaepaaahdtepvdtelkaatdrdaeksnIQNNLPRHVlkfnaLVAML 157 Aspergillus oryzae
Q7RZR9    79 PREVILKVLETLELLSqddgyqsdd----------------------------eseagetnGEKSVPFKQkf-itLVNML 129 Neurospora crassa
EDN95705  89 PREIIIGVVEAMSELDLedvednwde---------------------------epieneegTAVKESNEIdrfclLLSLL 141 Sclerotinia sclerot...
Q76PC4    97 PREVFLKCCELLINGGF--------------------------------------------------ESPqqfisLNSAI 126 Schizosaccharomyces...
4F52_E   132 QTVIQKLHNKAYS--IGLALSTLWNQLSLlpvp-yskEQIQMDDYGLcqccKALIEFTKPF------------------- 189 human
Q7JRC9   124 QVVLQRQGRDKPQa-VEWSLNSIFTHLKDlplpeylsEGYDEAQARLieqnEQVEDLLAHYitvglfr-----------e 191 fruit fly
Q5U3W2   128 QTVLLRLGMKKASs-VGMALSTLLSQVSRlpvp-vtaEQEEDDVFGLcrccSALLQFVKPFve----------------- 188 zebrafish
Q6PCE9   129 QEVLLKLGKRKAYs-VGLSLSTIHSRITClpvp-ftkEQTQEDKHGLcqccCAMVQFTKPF------------------- 187 African clawed frog
CAK48534 190 SVLHSRIQTKSPSrfLATSLQAVLEAYTLmpt---neTTYALLEFF-----RDVSPSKRPAppprvpsessv----lrls 257 Aspergillus niger
Q0CVJ5    99 ---------degGrfIATSLQAALEAYTLmpt---seTTMSLLEFF-----RDVSPSKRPApppraasessv----lrvs 157 Aspergillus terreus...
Q2UAW5   158 SILHSRIQTKSPSrfFATSLQAVLEAYTLmpt---neTTLALLEFF-----RDVSPSKRPApppraasessv----lrvs 225 Aspergillus oryzae
Q7RZR9   130 SILHKRIKTKYPSrfLATSLQTIYNTYRPnh-----eMTAAVINLV-----RSLAGNKRPPlptrkssvnvanpdqhgda 199 Neurospora crassa
EDN95705 142 AIIHPRIKTKHPSrfLANSIDTITNAFHPsh-----kAVLAVGKFI-----QTLSGKKRPTlpgrksslsitnfmrhevd 211 Sclerotinia sclerot...
Q76PC4   127 LSALHRISTKRPVlfVNNFLISLFSGLANi-------------------------------------------------- 156 Schizosaccharomyces...
4F52_E   190 ------VEEVIDNKENSLENEK--LKDELLKFCFKSLKCPLLta-------------------------qFFEQSEEGGN 236 human
Q7JRC9   192 plrdeiLQQDVRTPSQIFRDCGvnRRNIFTCFFIQLLGRPLA-----------------------------LLEMNHAKE 242 fruit fly
Q5U3W2   189 ----eiKEVVKDNNSISKDNE---LRVELLKFCMKSLSEPLLe--------------------------vQLKDTDTLQR 235 zebrafish
Q6PCE9   188 ------VDVVSQSKALIIEPDTaeLRKELLAFCFSCLKYPLLta-------------------------qLNLFPENTDD 236 African clawed frog
CAK48534 258 eksapdPEAEVQSPSPASDDESvlVQKFLQFGLIEALKSYLLsftgpsdpgmswairlqeklqpglrlakQETPSDAFAN 337 Aspergillus niger
Q0CVJ5   158 easapdPEAESQSTTPADNEEPalVRRFLQFGLIELVKSYLLsfssptdpgmcwairlqeklrpgtrmpgGQSQTEAFSE 237 Aspergillus terreus...
Q2UAW5   226 easapdPEAEVQSPNPS-NNEPalIKRFLQFGLIELIKSYILsfsgpmdpgmswti-rlqeklqtrhltgQVSETEVFAN 303 Aspergillus oryzae
Q7RZR9   200 tknapdPEADKDTEH---PTETaiQERLLLSFATCILESFVNkndvawaprll------efhnpekivpgRKTLMARFRE 270 Neurospora crassa
EDN95705 212 sslptaPDPESEEEE---SYESaiQQKLLQGFAVHILGLYINehpiewagrlq------elfepervvagRTSLCVAFRV 282 Sclerotinia sclerot...
Q76PC4   157 ------lQIDSDELYCVWKISIssIQDAMHRFPVSECYLACLkacsilaqlfls-----ketlmlsfrslLQTKDQYAEF 225 Schizosaccharomyces...
4F52_E   237 DPfryfaseIIGFLSAIGHP--FPKMIFNHGRKKrTWNYLEFE-----------------------EEENkqlADsmASL 291 human
Q7JRC9   243 DLtrsyvqqVTESLTQDANQflGDPFYLLNLVEQrARWLRKLDasrgvye---------mscqnvfLIEEklpLHavAMY 313 fruit fly
Q5U3W2   236 SPlrdfateILIILSDIGES--LPDLLSRNVLRRrKVP--GFL-----------------------EEEVrypKEslACM 288 zebrafish
Q6PCE9   237 NPffqfakdILGTFVLLGEP--LSVAFLQHGDRTpILEIEDVR-----------------------PEEGkctAEtfACL 291 African clawed frog
CAK48534 338 HKelkerdmIIAKITAPkdqp-----------------------------------------lpldFEEPprkAD----- 371 Aspergillus niger
Q0CVJ5   238 SKelrerdmIMAKITALS----RDFGLEDkllleivslp------------------senqpppldFDELpkkAD----- 290 Aspergillus terreus...
Q2UAW5   304 NKelserdmILGKITALS----RDFGLDDkqllavvsqp------------------adkhpqpldFDEPprnVE----- 356 Aspergillus oryzae
Q7RZR9   271 EKelsekdgAVGQLVALI----ADLGLSSCDktflsqvte-----------------gtlqtdplsKTEDiakPE----- 324 Neurospora crassa
EDN95705 283 DPglqirdeVTGQIVALC----RDLGLADynllfdtiyatp-------------piarvrsehedpRDNLpdsPE----- 340 Sclerotinia sclerot...
Q76PC4   226 REelsgattNCDKLDTLSKS---IINIFDYLLSH-LPESWSIItehmaqeltkatyvsqsssisseDEEIaknADvpAEV 301 Schizosaccharomyces...
4F52_E   292 AYLVFVQGIhIdQLPMVLSPLYLLQFNm--------------------gHIEVFLQRT--------EESVISKGLELLEN 343 human
Q7JRC9   314 YHSLFVGNQlPtNAPKVYAPLFLFETIv--------------------yLAEVLLRQQ--------EPPLQYCGLRLVEH 365 fruit fly
Q5U3W2   289 SHLLFVDHIaVdIFPAVFSPIFVLQCNm--------------------eYIELLLSRT--------EENRLQKGLELYEK 340 zebrafish
Q6PCE9   292 SYLLFVQHIgLdDFPFVFGPTFLLKTNm--------------------qHVDVLLKRT--------EESILSKGLELLEN 343 African clawed frog
CAK48534 372 ------------EIPLERHGSLLLLAAraataelfssg-qvspivifpdLARIFQNFVggynspdeVAFGQPQVLLDSLL 438 Aspergillus niger
Q0CVJ5   291 ------------QIPLERHGALLLLAAraamaelfssg-qvipiavfpdLANIFANFVggyntpddVAFGQPQALLDSLL 357 Aspergillus terreus...
Q2UAW5   357 ------------EIPLERHGALLLLAAraamaelfssg-qvtpiavfpeLAQIFDNFVgahdkpdeIAFGQPQALLDSLL 423 Aspergillus oryzae
Q7RZR9   325 ------------DIGLSTGGCVILLAYwvfsttvfdsdhpvpdmhifpdHLAMLEKFLqdd---aeDQIRKAPGTVQALV 389 Neurospora crassa
EDN95705 341 ------------EIPLSPNGSLFLLTSlvfsslmfktkspepvmsifpdHAKLVARFFd-------SADGSSIAIVDAVV 401 Sclerotinia sclerot...
Q76PC4   302 DNNSTKADDkRdEIEFDTKGCLALLTIksfyqsgnff--ldflkekfpsTILETLQQLvs-----wEIQLDSVGFKDIAV 374 Schizosaccharomyces...
4F52_E   344 SLLRIEDNSLL----------YQYL----EIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQG-KYTLFRC 408 human
Q7JRC9   366 HLSTLQ-HSVP----------TSSL----QLDVHKRFCEALCKIVGYSPQVALRQLGIHVLRQFVLAFDDHG-KYLILKN 429 fruit fly
Q5U3W2   341 SLVRVEENSLP----------VDLL----ELKTFFSVPQNLVKVMTMCPDQTLRTKGLKVFQLSIDKFNTEA-KYKFFRG 405 zebrafish
Q6PCE9   344 SLLRVEDESLH----------QDFL----EIKAVLHVVQDLEKVMTLCPIEHLRKRSLKLLQLMIDKFGEEG-KYKLFRC 408 African clawed frog
CAK48534 439 TLTVFSMQKPSd---------tTPH-----EKDFVDFVLTLTACTARQN----YSSVRRIPGTIIRTHPSQVtQFKVIRT 500 Aspergillus niger
Q0CVJ5   358 TLTVFSMQKTIg----------tPA----TEREFQDFILALTACTARQH----FSSVRQIPGIIVHSNPSPTaRFKIIRN 419 Aspergillus terreus...
Q2UAW5   424 TLTVFSMQRSIg----------ePS----TEIEFRRFILSLTACTTRQS----YNSIRRIPGTILHSHPSHIvRFKTIRL 485 Aspergillus oryzae
Q7RZR9   390 TIGLWLHDKGLisaipkaplaNQTTnpdeATSDYMRYILFVTLIAVFHPQLHVRNAASCLAGLVLHADPADDdRLKILYD 469 Neurospora crassa
EDN95705 402 AIGLWLEHSNKf--------vSGEF----KDNDYMAHLRALSLWSATNPSPGLRYCTHKLTSAILHAHPVDAiRLVFISK 469 Sclerotinia sclerot...
Q76PC4   375 YQGYLLDLPHFq---------VPDS----ELEHLSSLLHGYHFMASSTELPWLRVTCNAIVTKCLDSQLPSV-RLSYILD 440 Schizosaccharomyces...
4F52_E   409 LLNTSNHS----GVEAFIIQNIKNQIDMSLKRT------------------------------------RNNKWFTGPQL 448 human
Q7JRC9   430 LMGTLQHG----GLMGYLGGMYKDLVDKALGQSg-----------------------------------pMPEVYSGKLF 470 fruit fly
Q5U3W2   406 MLKTSHHA----GVEGYIIKNIKNQIDSSLKPGn------------------------------------SNDWFLGKHL 445 zebrafish
Q6PCE9   409 LFKSSNHA----GVQGYIIQNIKNQIDIALQTNs------------------------------------NSKWFLGPRL 448 African clawed frog
CAK48534 501 VLEDDRFQ----SVKDSAIGWLRTGILEAANSSkag------------------------------tsaEPSVYLDPHYF 546 Aspergillus niger
Q0CVJ5   420 VLEEENYL----TVKDSAIGWLQNEILSAVNESpt---------------------------------aEPSIFLNPHYF 462 Aspergillus terreus...
Q2UAW5   486 VLEDDRFQ----LIRDSAIGWLKDEILDANKKPsg--------------------------------spESDIFINPHYF 529 Aspergillus oryzae
Q7RZR9   470 LLENCDYA----SLKACAVTWLREELIAAAPNAqaapqnlaalnnqaplpspslqpgtatpgtrsragtNMNVFAGPQAL 545 Neurospora crassa
EDN95705 470 TLQGSPDEisaiALKVSAITWLKEELITAHERKs------------------------------------QNLFSTSSVL 513 Sclerotinia sclerot...
Q76PC4   441 TLEECPLL----NIKTAILNYYQKQCSLVKDSNeeg----------------------------------lknFVSPNTL 482 Schizosaccharomyces...
4F52_E   449 ISLLDLVLFLPEG-----------AETdllqnSDRIMASLNLLRYLVIkDNendnqt-glwtelGNIENNfLKPLHIGLN 516 human
Q7JRC9   471 REMLLLCVCVLPHd----------VKSdlllhSDRLCHALNILRYFAArDKndvtg---fwqalPEIEKElLDPLGTALN 537 fruit fly
Q5U3W2   446 LPLLRLVLCLPQG-----------PETdllqnLDRIMESLNLLRYMLI-RDkewdnetgiwtelYKIEDNyLKPMRTGLN 513 zebrafish
Q6PCE9   449 TPLLHMVLSLPEG-----------AETdllqySDRIMASLNLLRYLIIrQDnevdtktavwtelGRIENNyLKPLHIGLN 517 African clawed frog
CAK48534 547 SVVFPSLFNSSDLfmnvssdlvasFIKfsqtlSPSIHAALSLYYTIVSsPHlrkqlq--lektyVYFRNRfLEPLKSLCH 624 Aspergillus niger
Q0CVJ5   463 SVLFPSLFNPAQLllnvssdivasWIKfsqslVPSIHAALNLYYILVSsADlrsrlq--lgktyLFFRNRfLEPLKTLLH 540 Aspergillus terreus...
Q2UAW5   530 SILFPLLFNSSELllnvssdivasWIKfsqtlTPSIHAALSLYYILLSsSTlraqlq--lektyIYFRNRfLEPLKSLLH 607 Aspergillus oryzae
Q7RZR9   546 ETVQYVVFPNMGFlkel---dlqkLVNelgtnAPFFLQAVNFGLFLWSsADkwrrvl--ppnldATVKERwFAPLHDAVA 620 Neurospora crassa
EDN95705 514 LETKSQIFPNLSIlvdd---sdeeLTNdlmasFAVHMAALNFLFFITAeqyani----ippgmmTQVESEyIVPLKTAQE 586 Sclerotinia sclerot...
Q76PC4   483 LDVFKVFDAME-------------DVEldsqsLSYIHQTLVFLYSLEIqNLls----------qNQFPTVyFTKISDQIN 539 Schizosaccharomyces...
4F52_E   517 MSKAHYEAEiknsqeaqk----------------skdlcsitV--SGEEIpnmppemqlkvLHSA 563 human
Q7JRC9   538 FSMAHYKAYkervekgqsasddelmqrqlnmlavnisnsgmaGgdAESKLpdigrqekldvLASS 602 fruit fly
Q5U3W2   514 MSKAHYEAElrstkenrkigl----------keakasvcsvtV--GNEKLpnmtpetqiqvLQSA 566 zebrafish
Q6PCE9   518 MSKAHYEAEmksasekkkgl------------hskkaicsvtV--GENKLpdmtpeiqlqvLRSA 568 African clawed frog
CAK48534 625 AFEADLAQNggdg-------------------------kieaA--VGESLsqvgmarsvglISYM 662 Aspergillus niger
Q0CVJ5   541 AFQADLTQNggdg-------------------------kiesA--VGEDMchtgmarsvelISHA 578 Aspergillus terreus NIH2624
Q2UAW5   608 AFESDLTQNggdg-------------------------kiesA--VGENMcqvgmarsvglVSHA 645 Aspergillus oryzae
Q7RZR9   621 KVKKAVDSG------------------------------------EIEGQelgslqfdldvLSER 649 Neurospora crassa
EDN95705 587 RVLKFSGSS------------------------------------EDTEAphmelellgeqISMC 615 Sclerotinia sclerotiorum 1980 UF-70
Q76PC4   540 NYEGELpt---------------------------------------------------dgLKYY 553 Schizosaccharomyces pombe 972h-
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