7BMU,7DTI,8I53


Conserved Protein Domain Family
PH_TFIIH

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pfam08567: PH_TFIIH (This model is not part of the current CDD release)
TFIIH p62 subunit, N-terminal domain
The N-terminal domain of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity. The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal domain reveals that it adopts a pleckstrin homology (PH) fold. This PH-type domain has been shown to bind to a mono-phosphorylated inositide.
Statistics
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PSSM-Id: 518347
Aligned: 87 rows
Threshold Bit Score: 55.6961
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7BMU_A        35 TYK-----K-KEGILTLTE-DRkfLIWTp------LPATGP-PTVSLALDNITNLQQTPPGSAKVILKFTERPrpnaeP- 99  Thermochaetoide...
GAC75518      15 AFS-----K-VAGTLSLQTdQV--VKWVp-----sSSSSSV-SAFSISFGDIAGLQTSKEGAAQIALMLVLAN-----Gv 75 
XP_001729809  13 SFK-----K-VPGTLILHPnGV--LEWNp-----sSSTSSV-RGFRVPDIGLKGIQVSKPGAAQVALRIIAND-----Qt 73 
ELU42505      11 SFQ-----K-KPGYLVLTQ-RS--LSWT-------EDKQKE-PRLNLPNTSLQKMFFSKPGSASTSMKVMDGP-----D- 67 
4_pfamImport   1 VHK-----K-TPGTVWFTS-RR--ALWKa------ADGKAAvQRVEVAWAAVKSFQCSPASEARAMMRLLRV-------- 57 
XP_002288779  18 IYR-----K-TRGTLTLTE-RG--LLFKpegntaaDASSSSsTSVVLPWTQIEKHQVSPASHAKHLLKVIASss------ 82 
XP_048232194  11 KYKtslkdPgTPGRLLLTM-EK--LAFRp------NNPNSA-SKLDMDFKYVTNHKNTKEGSAKAMLNLTSN-------- 72 
Q55FP1        19 KYS-----S-QQGTLFFTS-LR--LVWV-------QSGYSE-PSLHLHISEIKNQFISTPKSAKALLRLSVRD-----Si 76  Dictyostelium d...
XP_020432736  19 KFA-----K-EAGTLYCTN-MR--LVWV-------QSGKIE-PSLHFHFSEIKTQFVSTSTSAKALLRLSVKD-----Ek 76 
XP_004362575  19 KFN-----K-EQGTLYCTN-LR--IVWV-------QLGKNS-ASLHFHLSDIKTQFISTEQSVKALLRLSVKE-----Qr 76 
7BMU_A       100 --GAPPpQYMFQFTHp--TdARAEANAIRDLLS 128 Thermochaetoides thermophila DSM 1495
GAC75518      76 qvASKP-KVLLVFNAa-qQtALDDREKFKTELA 106
XP_001729809  74 tiNGDS-SALLVFSAd-aDtAGKHRETFKERLA 104
ELU42505      68 ---PKInAYTFVFTS---LkAVAEGNNFKELIT 94 
4_pfamImport  58 --TEGQpPIIFRFTEtpgGtPREVLERAQAAVR 88 
XP_002288779  83 spTNTStSYTFAFLT------RNGLESARRDIT 109
XP_048232194  73 ----QGvSYIFEFEN------HDDLRICKEIVG 95 
Q55FP1        77 --KNALqEFVFEFTHp--TnARSDLNSFRDKIA 105 Dictyostelium discoideum
XP_020432736  77 -dSNATqDFLFEFSHm--SnARQDLNKFKERIG 106
XP_004362575  77 -dSIQTkDFLFEFIHg--QdARKDLNTFRDRIA 106
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