2A05


Conserved Protein Domain Family
Crisp
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pfam08562: Crisp (This model is not part of the current CDD release)
Crisp
This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.
Links
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Statistics
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PSSM-Id: 518343
Aligned: 63 rows
Threshold Bit Score: 45.3197
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2A05_A          3 CASCPNNC-ENG--LCTNSCDFEDLLSNCESLKTSAG---CKHELL-----KTKCQATCLCEDKIH 57  house mouse
XP_001602209  215 CSACGGHCrLGK--LCKNACPWADLWANCQQLRATWPgwlCDTDTEqgrerRQFCRATCRCDGKII 278
EFX86285      224 CGRCKGSCkLRK--LCTNSCSYADLWVNCRELNTTWNqwlCHNNSKegldrKKHCRATCECTGKIY 287
XP_973363     206 CSLCRNNCfARK--LCTNSCHVADLWANCKELYKVWPqwlCDTTSVkgqerKKHCRATCTCKNKIH 269
25_pfamImport   1 CSSCAQHC--RKgkLCTNNCDGVDLWFNCREIHRTWPqwlCESDGAkglerKQNCAATCNCKGKIT 64 
XP_049536718  215 CGSCQSHClSRKtrLCTNICSTADLWANCRELHRTWPgwlCNTATPeglerQRNCAATCTCQGKIH 280
XP_019698612  208 CSECKDHCvQEQ--LCTNACYYTDLWSNCAELVRTFDswvCETNTKegrerRKFCGATCNCKDKIY 271
14_pfamImport   1 CGDCPNHC-DKG--LCKSSVLYVDKYENCTHIRKRKG---CDTTYI-----ETNCPATCKCPSEMK 55 
XP_003215375  185 CGDCLDNC-EDG--LCTQTCEYMDAREDCKTMVLMFP---CENVYI-----QQVCAGTCKCPPGLV 239
XP_001846484  204 CSSCHQHChSKKikLCTNTCSSADLWANCKELYKTWPgwlCNTVTLeglerQRNCLATCTCQGKIH 269
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