4ZMI,4RQI


Conserved Protein Domain Family
TRF

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pfam08558: TRF 
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Telomere repeat binding factor (TRF)
Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.
Statistics
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PSSM-Id: 400735
View PSSM: pfam08558
Aligned: 27 rows
Threshold Bit Score: 108.26
Threshold Setting Gi: 929984928
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZMI_A          1 SIWDIEKAsllvnDCQNIANMAEQKVMMVSAIFSESSkdivNP--ESFSERLGK-ETVKDLYEfNEQLTTkyglefrtif 77   Schizosacchar...
Q4QRH9         15 nrWSFDFY-----AFQAFSAFRNGDYT---------------AftHFINIIESVvVRPVDGHTdMIPKLR---------- 64   zebrafish
Q9PU53         28 nrWVLQFY-----FHQAVAAYRAGRNR---------------DfrQLRDVMQALlVRPLEREPaVAQMLR---------- 77   chicken
AAI52523       31 qsWIIDYY-----FATLCRHFRERSSV---------------EfrKELKLFEGLvDELESHSSqRT-------------- 76   zebrafish
Q2LK75         18 tnWMCDFM-----FASMCFYFREDRTE---------------DfqRSTHMLEWLlEGSQKIDAhRKTIP----------- 66   African clawe...
P54274         75 agWMLDFL-----CLSLCRAFRDGRSE---------------DfrRTRNSAEAIiHGLSSLTAcQLRTIY---------- 124  human
4RQI_C         11 nrWVLKFY-----FHEALRAFRGSRYG---------------DfrQIRDIMQALlVRPLGKEHtVSRLLR---------- 60   human
Q1WM12         24 nqWAFDYY-----FHTAVEAFRSDRHE---------------DfqEIRDIVSVLlLRPLETKAqNDCKLR---------- 73   African clawe...
Q2GV64        289 SLPVLGNI-----AVQILLRLSQQPRTETESLLADSG----SEfrKAYDMLRDIfRPTRKAFS-DSPLLS---------- 348  Chaetomium gl...
XP_001585495  151 SLLSLESL-----SVQMLNILSEGGYDDVVVMVTQRD----TPrgQSFQTLKDLfDRTKKIYGtSTFLSA---------- 211  Sclerotinia s...
4ZMI_A         78 FSYIRKYDAYwclfedLEKPLKSIQFFTGLIDLLDNTN--KHLTLRSIVLDALLSADe-eDSFYGD--ALVLFEELVIRY 152  Schizosacchar...
Q4QRH9         65 ----------------LMQFLSRINNGDKLDLTFEEPK--TPLESALDVLESICRDM---SVPHTE--QQLIRHAISEVL 121  zebrafish
Q9PU53         78 ----------------VMQFLSRIEEGENLDCTFDKETelTPLESAIGILQLIAKEF---SVPEKK--IELIHKVLKEAA 136  chicken
AAI52523       77 ----------------VCCFLARVMDGENLDVRYDHVAriTPLMSAVPVWESL-------KDFSDPtlHGKIQTLLMVQS 133  zebrafish
Q2LK75         67 ----------------IAQFLMRVAEGKNLDSQFDTDEslTPLETALMAFNQIEEE----EDLKHL--HEEIELLLKVQA 124  African clawe...
P54274        125 ----------------ICQFLTRIAAGKTLDAQFENDEriTPLESALMIWGSIEKEH---DKL-----HEEIQNLIKIQA 180  human
4RQI_C         61 ----------------VMQCLSRIEEGENLDCSFDMEAelTPLESAINVLEMIKTEFtltEAVVES--SRKL---VKEAA 119  human
Q1WM12         74 ----------------IMQCISRIEEGEDPDCTFNDNNneTPLESAVGLLDIIQEEMpldEDLFKT--NKQM---VKEAA 132  African clawe...
Q2GV64        349 PDELDITDSE------DRETIRMSNLAATAASVFGAHDv-AVHDVHDAFFSIFIPED---GEYKSP--LTDLLVSLKTRM 416  Chaetomium gl...
XP_001585495  212 -DQLNFRDPA------QREIIRLANHATFVTSVFGGQEv-GFYELNEHFVDIWTREG---EPISKA--SGQLLMNLKTQI 278  Sclerotinia s...
4ZMI_A        153 FGTD---SNPSIDASEFILSCLPYTSLDAL------NVVCGQVWKSQKICDFLKSTIGNTSNSP-----LQLRASFPAFV 218  Schizosacchar...
Q4QRH9        122 VMVCi--RSGEFEKAEEMLKHFSSSSDS----------------------AGKKKLLLNLIRCRrsshtVLQLSSYSHFK 177  zebrafish
Q9PU53        137 VIVCi-kNKEFSKALAVLKRHMEKDTGN----------------------QKKRTELQTIIREKnrahpIIRDFSYVNFQ 193  chicken
AAI52523      134 VAVCv-kKGYDKLAKETLQWLEEQTDVP----------------------EKLQRKLATIVNKKdaydqILMNFSFDELM 190  zebrafish
Q2LK75        125 VVTCm-eKGRFKLSAEILDRLFKESGSN----------------------KYLRMKLTMLIEKKdpyheFLQNFTYAQMM 181  African clawe...
P54274        181 IAVCm-eNGNFKEAEEVFERIFGDPNSH----------------------MPFKSKLLMIISQKdtfhsFFQHFSYNHMM 237  human
4RQI_C        120 VIICi-kNKEFEKASKILKKHMSKDPTT----------------------QKLRNDLLNIIREKnlahpVIQNFSYETFQ 176  human
Q1WM12        133 VLVCi-kKQKFDQAIRILKKYISNYSK-----------------------RKLRAELHTIIREKnqnhpLITNFSFTTIK 188  African clawe...
Q2GV64        417 LLDAlnkPEQSQPVSQLLDALFPVTFEESLkqrsgdLLLNPDEEGLVARIRETREQLVKSAADEsikrsLEDQSSSLKFT 496  Chaetomium gl...
XP_001585495  279 IVAAlsmEESDRPVPELIAEMFSSEIRNFLaqr-hpYPLTDDERQLLLDLEIRRVYLINQGNDPakineLCNLFNWESFL 357  Sclerotinia s...
4ZMI_A        219 NAVIH 223  Schizosaccharomyces pombe 972h-
Q4QRH9        178 QDMLQ 182  zebrafish
Q9PU53        194 QYMFQ 198  chicken
AAI52523      191 ETIDT 195  zebrafish
Q2LK75        182 KKIKS 186  African clawed frog
P54274        238 EKIKS 242  human
4RQI_C        177 QKMLR 181  human
Q1WM12        189 KMIYQ 193  African clawed frog
Q2GV64        497 GILST 501  Chaetomium globosum CBS 148.51
XP_001585495  358 RSTHI 362  Sclerotinia sclerotiorum 1980 UF-70
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