6VVO,7Z6H,1IQP,6VVO,8DR0


Conserved Protein Domain Family
Rep_fac_C
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pfam08542: Rep_fac_C (This model is not part of the current CDD release)
Replication factor C C-terminal domain
This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.
Links
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Statistics
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PSSM-Id: 518328
Aligned: 305 rows
Threshold Bit Score: 38.983
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6VVO_B        258 PHPLLVKEMIQHCvN-ANIDEAYKILa-HLWHLGYSPEDIIGNIFRVCKTF--Q--MAEYLKLEFIKeIGYTHMKIAEGV 331 human
XP_025172391  250 VPDDIINDLIESAaS-KSYDKIQETVs-NVIASGYFGKQIIEQVFFQVLQDl---rFSENHKCNIGEsIGIVDKRLVDGG 324
XP_002432549  266 IPDSVITELINTCnK-NNYTTIEDFVn-EVTYQAYSVAQLMEQLTEYIIQDf---kLSDKAKATIFDkLSLCSSRLIDGA 340
EFA02756      261 VPERWLKKFLDVCkT-KDQNKLQAFLk-EMMFEAYAASQILEQLNQYIVNFe---gFTDQQKAIIGQkLGVVSFKLQDGG 335
XP_006637459  264 VPCKMIDSLLQTCyN-STFEKMESSVk-DLIDQGFAATQILNQLHDSVFEDe---rLNDKQKSAIAEkMAEVDKCLADGA 338
XP_005451167  268 MIDNLLQICFRGTfE-KLEVAVRNMVd-EGYAATQILTQLHECVIEQDLSDk----QKSTITEKMAVvCKCLSDGADEYL 341
27_pfamImport   1 VPSKMIEGLLQTCfK-GTFERLEVTVr-NLVNDGYAATQILSQLHESIIEs----dLKDKDKSIITEkMAVVSKCLSDGA 74 
XP_006351139  239 IPNEVVQAMFSACrS-GNFDLANKEVn-NVIAEGYPVSQMLSQLYDIVVDAd---dISDEQKARICKkFAEADKCLVDGA 313
A0BFQ2        257 IPDEQIEDLVSVIqT-KSIRSVQEECt-RVIQQGYNIEQLILQFLDVVLATd---tIKEKQKAKMMEiAAYTEKCLIEGS 331 Paramecium tet...
XP_004027236  258 IPDEHVINLYEVL-LqKNLNELRKSVqqFIYQ-GFSADQLINQFSDIILYSndIneIK---KARIFEkIAQADQGLNERA 332

6VVO_B        332 NSLLQMAGLLAR 343 human
XP_025172391  325 SEFFQVLSLLCK 336
XP_002432549  341 SEYLLLIDLCCT 352
EFA02756      336 SEFIQLLDLGCS 347
XP_006637459  339 DEFLQMIALCSV 350
XP_005451167  342 QLLSLCSVIMQE 353
27_pfamImport  75 DEYLQMLSLCSV 86 
XP_006351139  314 DEYLQLLNVVSS 325
A0BFQ2        332 AEDLQIFNLMAQ 343 Paramecium tetraurelia
XP_004027236  333 DSELQILNMFSC 344
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