Conserved Protein Domain Family
Glyco_hydro_42M

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pfam08532: Glyco_hydro_42M 
Beta-galactosidase trimerisation domain
This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation.
Statistics
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PSSM-Id: 369931
View PSSM: pfam08532
Aligned: 18 rows
Threshold Bit Score: 205.207
Threshold Setting Gi: 81545896
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8FA02       392 AEVALVHDIENARNWKHQ--PISTGLKfspvp-----------wsqvgYDIEMATWFSGMNVLNVNTHFRPASKiDFKNY 458  Leptospira int...
D9SM34       388 NEVAILYSSDQDFAFKIQ--PQVEGLY---------------------YLQQLKAFHNALIRLGVGTDIINWSE-SLNKY 443  Clostridium ce...
Q8A069       726 RRTAILFNHENSWSIERQ--KQNRTWD---------------------TFAHIEKYYRTLKSFGAPVDFVSEQK-ELTEY 781  Bacteroides th...
Q92UN3       396 AQVAIVLDYESRWATRVL--PQGRSYS---------------------ASAVALDWYSTVARLGVDVDFIGQHS-DIAGY 451  Sinorhizobium ...
ADE01962     394 ASVALVHDYESLWATRSQ--PLSPDWDywnhlrtyydalradveppsgVTSSLRTYYDALRARGVQVDIVSPEA-TLERY 470  Haloferax volc...
O31529       387 AEAAMTYSDRAKAFIKTE--PH-RGLR---------------------HRSLVTHFYERILNTGIHRDLIPEGA-PLDGY 441  Bacillus subti...
Q5WC61       410 ADVAIIYDWENQWAIDDAqaTNNIDKG---------------------YASQVQSHYRSFWKHGVPVDVVSMND-DISTC 467  Bacillus claus...
WP_002209897 403 ADVAIIFDWESRWAMDDAegPRNCGLE---------------------YEKTVAEHYRPFWERGIAVDIINADC-DLSGY 460  Yersinia pseud...
Q8XP01       407 pQVAVIYDWENYWAINDAqgPRIEQKD---------------------YFETCQKHYKAFWDMSIPTDVINMDC-DFSKY 464  Clostridium pe...
Q82N52       398 ARTALLFDWDSWWALEISdgPS-RLVR---------------------YQDQVHAYYRAAREAGADIDVVPVTA-GLRAY 454  Streptomyces a...
Q8FA02       459 KIIILPMYTMVNETVFKRLEEFVREGGTLVLGFRTGAKDLNGWMYDSQIPGPFAEMAGIKIRKFESVGNqkVKFRFRfFP 538  Leptospira int...
D9SM34       444 KVVIAPTLYLTDDNVTTELYRFVEAGGTLILTNRTGVKNMNNVCLMEQMPSNLKECAGVVVKEYDPIGH--SIHTIKdEA 521  Clostridium ce...
Q8A069       782 PVVIAPAYQLADKELVNKWIAYVKNGGNLVLTCRTAQKDRYGRLPEAPFGSMITPLTGNEMNFYDLLLPe-DPGTVV-MN 859  Bacteroides th...
Q92UN3       452 KLILAPDLVIAEEAF---VERLTRADAKVVFGARSGSKTRDMHIPEGLPPGPLAKLIDISVSRVESLPEf-HSETVL-YG 526  Sinorhizobium ...
ADE01962     471 DAVVAPTLYLVGDELSTALTDYVDSGGCLLLGARTGEKDPYNRLHESLAPGPLTALTGAQVARHETLPDh-VETRLS-YD 548  Haloferax volc...
O31529       442 RLLFTPFVPYLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKT--LFTFPMn-ENVNTGkAF 518  Bacillus subti...
Q5WC61       468 KIVVAPMLYMLKPGVAEQIEAYVKNGGTFIATYWSGIVDETDLCFLGGFPGPLKPVLGVWAEEIDSLYKh-ETVPFT-WN 545  Bacillus claus...
WP_002209897 461 KLVIAPMLYMVREGFAERATRFVEQGGQFVATYWSGIVNESDLCHLGGFPGPLRPLLGIWSEEIDCLADg-ESNQVQgLA 539  Yersinia pseud...
Q8XP01       465 KVVVAPMLYMVRPGVGERLEEFVKNGGTLVTTYWSGIVDENDLCFLGGFPGPLKKVTGIWAEELDALYDe-DVNYVSiEE 543  Clostridium pe...
Q82N52       455 DVVLAPALHMVKGDLAGRLEAVAARGGTVLTTFLSGRVDTHDRAFLADVPGPLAPLMGIRVDEWDARPAd-TAHPVTlGD 533  Streptomyces a...
Q8FA02       539 GTC---------SKICEIL---EPTTAEVWARYTDgkKFYKGSPV----ITANNYHK--GKVIYVGS-----SLEPLSFV 595  Leptospira int...
D9SM34       522 GKVyq------cKQWCDIL---EPTTAKVIATYND--DFYIDEAA----VTVNKYKK--GNVYYLGT-----VFNSDYYI 579  Clostridium ce...
Q8A069       860 GKQye------wNTWGEILi--PASDSQVWATYAN--EFYEGGPA----VTFRKLGK--GTVTYVGVdshngALEKDILK 923  Bacteroides th...
Q92UN3       527 NEAye------aGGWRETVrtsETVIASFDGEYRN------GAPA----LVGS------DKARYLAV-----AANGALLD 579  Sinorhizobium ...
ADE01962     549 GATye------fRTWASWL---APEVGVPRGEYRT--GEAAGNTA----IVRNAAGD--GSVTYCGC-----WPGDDLAD 606  Haloferax volc...
O31529       519 GITap------lGLWSAVF---DTESGNTLGTVEA------GPGAghafLTERNYGE--GKIVMLGSlp-sgKEGDAMLE 580  Bacillus subti...
Q5WC61       546 GDTye------aHSFIERI---HLKGAETIAAFQG--G-SSPTPA----VTKNRLGK--GTAYYMAS-----ANEQRFYD 602  Bacillus claus...
WP_002209897 540 GNKaglqgpyqaIHLCDLI---HLEGATAVARYRD--DFYADRAA----VTVNFVGE--GKAWYVAS-----RNDAAFQR 603  Yersinia pseud...
Q8XP01       544 GNSlgmkgeyeaRIFCDLI---HSEGAEVLATYKT--DFYKGMPA----LTCNNFGE--GQAYYIAF-----RNNDEFLS 607  Clostridium pe...
Q82N52       534 DKDvvh---tdaRLVFEIV---LPRGAEPVGTYQA--DFYAGTPA----VTRHRFGErgGEGWYVAT-----ALAQPGVD 596  Streptomyces a...
Q8FA02       596 LLYRRILKE-AKIP 608  Leptospira interrogans
D9SM34       580 ELLSKILDE-KELP 592  Clostridium cellulovorans 743B
Q8A069       924 KLYAQLQIPvMDLP 937  Bacteroides thetaiotaomicron
Q92UN3       580 KVIGDALGW-AGLE 592  Sinorhizobium meliloti
ADE01962     607 ALVTELLDA-AGVE 619  Haloferax volcanii DS2
O31529       581 ALVRHYAEE-AVIS 593  Bacillus subtilis subsp. subtilis str. 168
Q5WC61       603 AFYELLINE-HGLA 615  Bacillus clausii KSM-K16
WP_002209897 604 DFFMNIAEE-LNLa 616  Yersinia pseudotuberculosis complex
Q8XP01       608 DFYSSLAKK-LTLk 620  Clostridium perfringens
Q82N52       597 WVVRRVLAR-HDLI 609  Streptomyces avermitilis
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