Conserved Protein Domain Family
rRNA_processing

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pfam08524: rRNA_processing 
rRNA processing
This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.
Statistics
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PSSM-Id: 400708
View PSSM: pfam08524
Aligned: 28 rows
Threshold Bit Score: 57.3165
Threshold Setting Gi: 891585818
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001524784               6 HSKKRFTnrKET--KTADIKRALTHRA---RLRKNYFKLLKSEGLEEHEKlnleADKRSNDEDESGDSHDDSASDEEVgd 80  Lod...
WGS:AAFB:cds.EHI_140020A  33 KTKEKIEqlKQMkkNEKKIEKLIAENAnpnSFYDKYFKGELDDEMEEENNvgfkELIKNQEKQQTKKTIQQARE------ 106 Ent...
XP_002597411              14 KGRQGFAd---------------RRKK---KVMYEYRKLLNKERKKKGGTaaaaATGSAGVEEGYTEQKGDGNTQAGGee 75  Flo...
XP_001607665              28 FNKKKYRe-QKYsnKFKVNQWEEKRKK---AILKGFYKDLKKEEKAANFKfsrkSNSENPEDDNSESSSKKAK------- 96  jew...
EFN84662                  28 FDKKKYRl-KKYsnKYKINQWEERRKK---TVLRDFHKELKRDQQNSTQAsinsNNTSKDAQE-TSN-SKKA-------- 93  Jer...
XP_012061822              28 FDKKKYRl-QKYsnKYKINQWEERRKK---AVLREYYKELKKDQQNSAGTssnlSNTSKNTNE-TSKLKKNS-------- 94  Att...
EFN70173                  23 FDKKKYRl-QKYsnKYKINQWEERRKK---AVLREYYKELKRDQQTSSQIssncA--SKNTNE-MSNSKSKS-------- 87  Flo...
BAH71391                  12 FDKKKWRt-KKYsnKQKFQDWDERRKK---AVIRDYYKELNKSGNERP------LDTLNDEDNNLTKQQKRP-------- 73  pea...
EFX88179                  16 FNKKKWRe-TQYshKERVSEWESKRKE---AVKRKYRKMLKKDESTSSvq--ttYQLYNAEEGNVNGYSEPPRQRL---- 85  com...
CCE87048                  11 NTRFSYKdrHEL--KSKEIKKSLTHRA---TLRRKYFKMLENEGLSSNAGeakeREGASGDHESEEASLSEKPEHGESre 85  Mil...
XP_001524784              81 kehteklisknkkhsisskqkpLNFAERAAIAKQRKEEQRKAKLAQVQEKLQHI---EKQQKIRELKKQQLKQKTKYGQP 157 Lod...
WGS:AAFB:cds.EHI_140020A 107 --------------------------ERKEIIKEKKKELEEQKLNQLER--------EKRKKEKLKEKKILLQKTKKGQP 152 Ent...
XP_002597411              76 qkrf------------kkkppvTAFSRQQQEFKKKQAEKEQRIKEAEQRKEDRIkaaAKHNKERWKRHVQLGKKNKKGQP 143 Flo...
XP_001607665              97 ----------------------IPFFSAKQEYLKKKQEKDRKKEELLKAQEERKkalEKYKEKKMQTYKQLSKKTKKGQP 154 jew...
EFN84662                  94 ----------------------YAFHKAKQKYQETKKEKERKKQETVRIKSEREealKRYKEKKMQTFKVLSKKTKKGQP 151 Jer...
XP_012061822              95 -----------------------AFFKAKREYRRKQEEKKNRLENAIRVKTEREealKKYREKKLQNYKVLSKKTKKGQP 151 Att...
EFN70173                  88 ----------------------YAFYKAKQEYKRKQEEKKKRIQDMIRVKAEREealKKYKEKKLHNFKMLSKKTKKGQP 145 Flo...
BAH71391                  74 ----------------------NPHKEAQERYNQIQEEKKARRFEASKKKEEIRqalEEYKQKKKLKNKKLGKKTRKGQP 131 pea...
EFX88179                  86 ----------------------SEFQRAKLEYERIQGLKEEARLEREQKIKEREiaiMKSKQMRLERIKKLTQKTKKGQP 143 com...
CCE87048                  86 hearekt-------nvkqtkkaLPYIERAKKVKELKEKRRQEKLKQIRDQLKAS---ESKTLQRQKEKEILSQKTKRGQP 155 Mil...
XP_001524784             158 VMGPRINNLLDKIKRD 173 Lodderomyces elongisporus NRRL YB-4239
WGS:AAFB:cds.EHI_140020A 153 IMNNIMNKLLKDIEHq 168 Entamoeba histolytica HM-1:IMSS
XP_002597411             144 VMANRIEFLLNKIQKE 159 Florida lancelet
XP_001607665             155 VMKGRMELLLEKIQQS 170 jewel wasp
EFN84662                 152 IMKGRIEMLLEKIQQs 167 Jerdon's jumping ant
XP_012061822             152 VMKGRIEMLLEKIQQi 167 Atta cephalotes
EFN70173                 146 VMRGRIEMLLEKIQQs 161 Florida carpenter ant
BAH71391                 132 VMKERLELLLEKIQAs 147 pea aphid
EFX88179                 144 VMKGRIEILLQKIQKQ 159 common water flea
CCE87048                 156 LMGPRINNLLDKIRKD 171 Millerozyma farinosa CBS 7064
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