Conserved Protein Domain Family
MBF1

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pfam08523: MBF1 
Multiprotein bridging factor 1
This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilizing the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.
Statistics
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PSSM-Id: 400707
View PSSM: pfam08523
Aligned: 111 rows
Threshold Bit Score: 46.113
Threshold Setting Gi: 75034805
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EER44566       4 DWDSVT-RIGSKVRgggggglRETVVRGRSALNAAARSGAIIGTEKK-YTTGNTASKPhvEGQHLTKVDRSDDIIPLQ 79  Histoplasma capsu...
Q4MYI3         5 DWKPVVwTKHENFK----------GPNKESALNKARRAGVELDTQKKfLGGQNKTTKSf-LPPNAAKIENENESFHIE 71  Theileria parva
XP_001608675   6 DWTPVVwSKKDNCR----------GPQRKAALNDARRTGEDISTEKKfLGGLNKSTKAy-LPSNAAKIDNETEDFRIE 72  Babesia bovis T2Bo
XP_002142398   4 DWNTVVwNKGSTRTk---------GVSKEQDLNIARRRGEEIITEKKfFGGKNTSTKKl-AMPNAARLDQDTGDYRIE 71  Cryptosporidium m...
Q8II81         5 DLKPVIwHKTEKKT-------------KPKDIHEARKLGIDVEVEKKyFGGKNKSSKGnlIIENKAKIEQETENFKID 69  Plasmodium falcip...
EEH52158       5 DWKPVV--LTKKKP-------TGGMNGVPKSADAARRMGMAVDTVKKqGGGYNA--------QRMGKLENETDELQHK 65  Micromonas pusill...
Q388C5        11 DWEPQVfNIHNRKNtqq-----rpTRVSEAEANRALQRGGNVEVIKKeHFRSNVQKGG--PGANAKRLDEDTETLKVK 81  Trypanosoma brucei
XP_003373148   8 gWDTVTi-LRKNQP-------RKSEARQEKVVRAAQRSGQEIETSKKfNAATNRqh---qMSASVSKLSSDLEEFHHN 74  Trichinella spiralis
CBX85978      12 DPNVVTm-ITKRGP-------VNKTLKSASQLNAAQRSGAEISTEKKtMSGGNRqh---tANKNTLRLDEETEELHHE 78  Caenorhabditis br...
PDM75273      12 DPNDVTi-IRKHQP-------ASRVLKSQADINAAQRRGANIETNKKvMAGGNRqh---sAAKNTLRLDEETEELHHE 78  Pristionchus paci...
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