Conserved Protein Domain Family
BT_3987-like_N
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pfam08522: BT_3987-like_N (This model is not part of the current CDD release)
BT_3987-like, N-terminal domain
This domain, previously known as DUF1735, is found in a number of proteins mainly found in firmicutes, including BT_3987 from Bacteroides thetaiotaomicron, which displays hydrolytic activity against Hy-type N-glycans, probably initiating the degradation of this type of glycan in the human gut. This domain adopts a beta-sandwich fold.
Links
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Statistics
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PSSM-Id: 518314
Aligned: 144 rows
Threshold Bit Score: 34.2835
Created: 15-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013443969   27 FKYs--sVYFA-----------YQYP-VRTITLGedi-fdtSLDNQHK--CA-IYAT-MGGvyDNKk----DVIINF--N 81  Paludibacter p...
Q8AAM3         28 RDN----LMVN-----------DQIGlLHSTYTEt-----eIFRGMDTp-YQ-LFVI-KSG--KGKq----ETEVSI--S 76  Bacteroides th...
WP_015782912   31 YQG----VFLD------------GNN-VVEVYVQe-----yQDNKIQN-----LKVKlIRA--AGK-----IVSAQL--I 74  Capnocytophaga...
18_pfamImport   1 LFLqimdVIMPal--------gFTST-SVTVDQYn--------yGSAPd-LN-KNIG-IGLd-TDNk---wDITGQL--V 54 
3_pfamImport    1 ------nQLFLqlkevitptigFKDS-YVNVKAYt--------yGLVSk-IS-EKVP-FKLd-TNNk---wDIECEF--V 56 
5_pfamImport    1 YSKr--vSYLT-----------LDVTqENGVGFEegknsvmVAGNESFtgYD-LPLMaYIA--SDN-----DINIGL--E 57 
Q8AAM3        162 IVPtikePYLQmd-------vpGMSP-VTDFMPTf--------gDLNE--RE-LFVK-IRT--NYSnd--eDISFQI--E 215 Bacteroides th...
Q8A176         33 FEKr---TYLI------------ENG-WKDYQLEv--------dDDNT--AI-LPVY-FGI--NGTslndkDITLTL--D 80  Bacteroides th...
WP_014790192   28 PES----KMIAng-------enKIFN-KANPSEDy-----tKATGDES--IN-LVVE-LNS--EVSi----NTPITIanE 80  Ornithobacteri...
WP_014791526   29 FAShq-gIYFT------------------QQSLQa-----fVAEGASSt-IDgLKLN-LVN--KENk----NSFATI--E 74  Ornithobacteri...

WP_013443969   82 V-ADSICTGY-NlvsnptggraaNPT------VpisFMPHDYYTLTsNQIVIK-KG--DISGGVEVQLTDkffadp--ks 148 Paludibacter p...
Q8AAM3         77 V-DETVLQSY-Ntd--------nGTSi-----Q---LLPSDCYTI--LQPALRlNDs-DYRKAFDIKWNAdrlsdl--ls 133 Bacteroides th...
WP_015782912   75 TgDAQTLTDY-Naq--------yGTDy-----K---LLPTDKYSId-ENAIFNt---yETETPIDITISEltfp------ 127 Capnocytophaga...
18_pfamImport  55 V-DEAYIAEY-Nee--------nGTVy-----Q---MLPEGTYTVP-ESVTLA-SG--ITNSGISVSVTAstl------- 105
3_pfamImport   57 V-DNEYITQY-Nnt--------nGTVf-----Q---ILPENSYSFA-SSMPLP-NGt-TE-TTLLVEVKGsql------- 107
5_pfamImport   58 V-DNSLVAAF-Nsk--------yGTAf-----K---TLAVSDWEL--ADVALP-AG--STTATGHIAYKGetsq-----f 109
Q8AAM3        216 V-DPQLVIDY-N-----------TAHgt--ayK---MLPESSFTVDnKGVILTg----MKETFIKIKYHKkglipeegty 273 Bacteroides th...
Q8A176         81 V-DPDTLERY-Nwe--------kYKNqkelylK---LLPEESYTFDaSSWTIP-SGelNTSAYIKISLDKikevg----s 142 Bacteroides th...
WP_014790192   81 SqTEKIVEKFkKfk--------nTKDy-----Q---ILPTDYYEI--SEGTLT-AG--TKSTELQVDIKSyadl------ 133 Ornithobacteri...
WP_014791526   75 YgDEKQLEAY-N-----------KENgt--syI---MLPKDMYNAk-SSVSIK-PN--YITSSIPIQLKDlkfs------ 127 Ornithobacteri...

WP_013443969  149 ltnNYVIPLQMTTATNVD 166 Paludibacter propionicigenes
Q8AAM3        134 tgkEYGLPIQMSVVQNFI 151 Bacteroides thetaiotaomicron
WP_015782912  128 nneVYALPIQIRGRNNIE 145 Capnocytophaga ochracea
18_pfamImport 106 epgDYMLPIRINSVSQFS 123
3_pfamImport  108 qpgDYMLPIRIKNVSQFE 125
5_pfamImport  110 agdNYLVPIKIKSVTSPG 127
Q8AAM3        274 lfgDYVLPLRITSVSKYG 291 Bacteroides thetaiotaomicron
Q8A176        143 lynDYVLPLRINSSVGEP 160 Bacteroides thetaiotaomicron
WP_014790192  134 pqgNYVLPIQIDV-NGks 150 Ornithobacterium rhinotracheale
WP_014791526  128 regDYALPIKIIGGSADV 145 Ornithobacterium rhinotracheale
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