Conserved Protein Domain Family
GIT_SHD

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pfam08518: GIT_SHD 
Spa2 homology domain (SHD) of GIT
GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ). The function of the CAZ might be to define sites of neurotransmitter release. Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase.
Statistics
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PSSM-Id: 400702
View PSSM: pfam08518
Aligned: 56 rows
Threshold Bit Score: 42.3841
Threshold Setting Gi: 195997397
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESA44030            118 ARDKLQRLTEVQFLELSTDVYDELKRREQ 146 Neurospora crassa OR74A
EDS44164            602 GRQKLARFSQQEFNGLISDVLIDARRRQN 630 southern house mosquito
WGS:AAPP:GF11095-PA 375 GRQKLARFNRAEFAGLLTDVLVDAMRRQN 403 Drosophila ananassae
XP_028038181        325 GRQKLARLSPRELAALLRDVLLDATRRQR 353 wild silkworm
XP_967293           319 GRQKLARFSTPELKSLVFDILIDTQRRQL 347 red flour beetle
XP_015784059        342 GRQKLARFSAKNFTSLLIDVLIESKRRQL 370 two-spotted spider mite
XP_001636194        328 GRQKLALFNAQELTTLIIDILNEARRREQ 356 starlet sea anemone
TDH12875            319 GRQKLARFNAHEFATLVIDILSDAKRRQQ 347 yellow perch
EFX84315            338 ARQKLGRLNAREFATLLIDLLSEAKRRQQ 366 common water flea
Q1RLG9              325 GRQKLARFTQQEFFVLITDILCDIIRRQs 353 vase tunicate
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