pfam08518: GIT_SHD (This model is not part of the current CDD release)
Spa2 homology domain (SHD) of GIT
GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ). The function of the CAZ might be to define sites of neurotransmitter release. Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase.
Jiyao W et al.(2023). "The conserved domain database in 2023.",