1V06


Conserved Protein Domain Family
AXH

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pfam08517: AXH 
Ataxin-1 and HBP1 module (AXH)
AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1). ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans. The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression.
Statistics
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PSSM-Id: 400701
View PSSM: pfam08517
Aligned: 44 rows
Threshold Bit Score: 121.506
Threshold Setting Gi: 196003098
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1V06_A        12 FLKGTRLCFHKEsn------kEWQDVEDFAraascdNEEEIQ-M-----------GthkgYGSD-GLKLLSHEESVSFGE 72 
EKC21404     196 FIKDTRVHFVGGsarqtrelwDWQSVEQLA------LQERIA-SqaagadskpgqS----FGGS-GLRLCSINKRADTID 263 Pacific oyster
XP_023807920 205 FLKGSRLRFHSGvn------vEWQDVEDLE------SAERQR-Tdeels--dflkS----YGSE-GLQLMEHAETVLSGQ 264 Japanese medaka
XP_003455770 212 FLKGTRLHFHSSsk------iEWREAEDLE------SAEEDS-Adekqs--rflkS----YGSE-GLQLVEHAEIVLSGQ 271 Nile tilapia
XP_027899893 194 FLKGTRLRFHRGsc------mDWQDVEDMG------SGDEHR-Adeers--rflkS----YGSE-GLQLVEHEETVSCGQ 253 Monterrey platy...
CAG08710     161 FLKGTRLRFHRGpn------vEWQEAEELR------DSDDDS-DdemmpssssrkR----YGSE-GLKLVNHEETVSFGQ 222 spotted green p...
XP_001628206  11 FLDGTRVQLEGEs--------DWRFAEDLG------NDDIPR-V-----------S----LPEE-GLKLTSCHRVDLNME 59  starlet sea ane...
XP_002111416 201 FMKGTKIKFSASnq-----qvSWIAAEELG------KNDKLV-Rqlgq---iegpT----TYAPfGLKLMEVKEIKGNSD 261 Trichoplax adha...
XP_031162351 207 flkGTHLRFHRGsn------vEWQDVEDLD------SAHEDSgDeeqp---rslkS----YGSE-GLQLVEHSEIVLSGQ 266 pike-perch
CAF96275     177 FLKGTLVRFHGGsr------mKWQDVDDLD------STEEDS-Adeeq----slkT----FGSE-GLQLVDHTEIVLSGQ 234 spotted green p...
1V06_A        73 Sv-----lKLTFDPGTVEDgLLTVECKLDHPFYVKNK---------------------------GWSSFYPSLTVVQHGI 120
EKC21404     264 Nkg----lRLSFSTGVTDQpSLQVECEEAHPFFVKDK---------------------------GWSSINPTLTYDRYGI 312 Pacific oyster
XP_023807920 265 Tv-----lQLTFDPGVFGHtPVTVRCPLDHPFYIKSK---------------------------GWSSFYPSLTVVHHGI 312 Japanese medaka
XP_003455770 272 Av-----lQLTFDPGTFGYiPLTARCQLDHPFYVKNK---------------------------GWSSFYPSLTVVHYGI 319 Nile tilapia
XP_027899893 254 Av-----lQLTFDPGVFGHtPITARCQLDHPFYVKNK---------------------------GWSSFYPSLTVVHYGI 301 Monterrey platy...
CAG08710     223 Av-----lKLTFDPGS-DDgMLTAECRLDHPFFVKTK---------------------------GWSSFYASLTVVHHGI 269 spotted green p...
XP_001628206  60 Eky----vLATFHSTTADQpSLRAEVACGHPFFVKAK---------------------------GWSSFRPSLTAEQYGI 108 starlet sea ane...
XP_002111416 262 KrkrknllIMRFSSTVNGQpRIAARCLADHPFYVKEK---------------------------GWSSFCPELTNSQYGI 314 Trichoplax adha...
XP_031162351 267 Av-----lQLTFDPGAFGHtPMTARCQLDHPFYVKNK---------------------------GWTSFHPSLTVVRYGI 314 pike-perch
CAF96275     235 Av-----lQLTFDPGAFGRtRVTTRCQLDHPFYVKNRggsdsgddpaphmvqahshpffslffpGWSSFYPSLTVVHHGI 309 spotted green p...
1V06_A       121 PCCEIHIGDVCLPP 134
EKC21404     313 PCNVLSELDLCLPP 326 Pacific oyster
XP_023807920 313 PCYEMEVGDTCLPP 326 Japanese medaka
XP_003455770 320 PCYEMEVGDVCLPP 333 Nile tilapia
XP_027899893 302 PCYEMEVGDMCLPP 315 Monterrey platyfish
CAG08710     270 PCYEMQLGDVCLPP 283 spotted green pufferfish
XP_001628206 109 ICQTLACGDVCLPS 122 starlet sea anemone
XP_002111416 315 NSKFLKINDVCIPP 328 Trichoplax adhaerens
XP_031162351 315 PCYEMEVGDVCLPP 328 pike-perch
CAF96275     310 PCYDMEVGAVCLPP 323 spotted green pufferfish
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