4APT,1V06,2M41


Conserved Protein Domain Family
AXH

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pfam08517: AXH (This model is not part of the current CDD release)
Ataxin-1 and HBP1 module (AXH)
AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1). ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans. The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression.
Statistics
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PSSM-Id: 518309
Aligned: 36 rows
Threshold Bit Score: 123.872
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4APT_A        12 FMKGSIIQLA---NG---ELKKVEDLK------TEDFIQ----S------------AEISNDLKIDSSTVERIEDSHspg 63  human
2_pfamImport   1 FLKGSRLRFH---SGvnvEWQDVEDLE------SAERQR----Tdeels---dflkSYGSEGLQLMEHAETVLSGQTvl- 63 
7_pfamImport   1 FLKGTRLHFH---SSskiEWREAEDLE------SAEEDS----Adekqs---rflkSYGSEGLQLVEHAEIVLSGQAvl- 63 
5_pfamImport   1 FLKGTLVRFH---GGsrmKWQDVDDLD------STEEDS----AdeeqslkvqgaaTFGSEGLQLVDHTEIVLSGQAvl- 66 
XP_006633384 227 FLKGTRLRFH---KGnnvEWQDAEDLA------DSDDES----Ederdsq-chslkSFGSEGLKLVAHEETVSFGQSvl- 291
XP_006006054 227 FLKGTRLCFH---KGhtrEWQDVEKFA------NGETHY----Egkrdin-wntykGYGSDGLKLISHEETLSFGQSvl- 291
XP_017947540 220 FLKGTRLCFH---KGrkkQWQDVEEFA------KSTRCR----Nergi----dsykGYGSDGLKLVSYEECVSYGESvl- 281
XP_008109779 214 FLKGTQLCFH---KGakkEWKDVEDFA------RFTGYK----Neaeds--mssckEYGSDGLKLISHEETVSFGESvl- 277
1V06_A        12 FLKGTRLCFHkesNK---EWQDVEDFAraascdNEEEIQmgthK------------GYGSDGLKLLSHEESVSFGESvl- 75  house mouse
XP_046786734 214 FLKGSRLCFH---KGrnkEWQDIEDFA------RSEGCG----Kednls--vsaykGYGSDGLKLISHEESISFGESvl- 277 chicken
4APT_A        64 vavIQFAVGEHRA-QVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLT 124 human
2_pfamImport  64 --qLTFDPGVFGHtPVTVRCPLDHPFYIKSKGWSSFYPSLTVVHHGIPCYEMEVGDTCLPPG 123
7_pfamImport  64 --qLTFDPGTFGYiPLTARCQLDHPFYVKNKGWSSFYPSLTVVHYGIPCYEMEVGDVCLPPG 123
5_pfamImport  67 --qLTFDPGAFGRtRVTTRCQLDHPFYVKNRGWSSFYPSLTVVHHGIPCYDMEVGAVCLPPG 126
XP_006633384 292 --kLTFDPGSQEDgLLTAECSLDHPFYVKNKGWSSFYPSLTVVQHGIPCYEMQVGDLCLPPG 351
XP_006006054 292 --kLTFDPGSPEDgLITVECRLDHPFYVKSKGWSSFYPSLTVVQHGIPCCDIQVGDICLPPG 351
XP_017947540 282 --qLTFDPGTTDGgLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHVGDVCLPPG 341
XP_008109779 278 --eLTFDPGTEGDcLLTVECKLDHPFYVKNKGWSSFHPSLTVVQHGIPCCEMHIGDICLPPG 337
1V06_A        76 --kLTFDPGTVEDgLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPG 135 house mouse
XP_046786734 278 --kLTFDPGTVEDgLLTVECRLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEMHLGDLCLPPG 337 chicken
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