6EIX


Conserved Protein Domain Family
TGF_beta_GS

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pfam08515: TGF_beta_GS 
Transforming growth factor beta type I GS-motif
This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
Statistics
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PSSM-Id: 400699
View PSSM: pfam08515
Aligned: 21 rows
Threshold Bit Score: 33.6671
Threshold Setting Gi: 1752348268
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EIX_A        10 TLADLLDH-SCT--SGSGSGLPFLVQRTVAR 37 
EDO30434     152 SLCDLITNaDIS--TGSGSGLPLLVQRTVAR 180 starlet sea anemone
XP_026799719 216 SLKDLIEQ-SQS--SGSGSGLPLLVQRTIAK 243 striped catfish
EFX86076     191 TIKDMVDH-SQS--SGSGSGLPLLVQRTIAK 218 common water flea
XP_005640249 115 TLQDLICD-VAA--SGSGSGLPLLVQRTIAR 142 dog
OWR50038     240 TLRQYLEG-SAT--SGSGSGQPLMVQRTLAK 267 Danaus plexippus plexippus
Q659I3       133 YFPEFTD-------SGSGSGKPFLVSQTIAR 156 Echinococcus multilocularis
NP_001093904 173 NMQDLLDD-KDFstTGSGSGLPLLVHRTIAR 202 vase tunicate
Q4H2Q1       171 GHNEMMENwSSLagTSSGSGMPLLVQRTISR 201 vase tunicate
XP_014237384 195 TLKEYLEGqSLT--SGSGSGLPLLVQRTLSK 223 Trichogramma pretiosum
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