3MDY


Conserved Protein Domain Family
TGF_beta_GS
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pfam08515: TGF_beta_GS (This model is not part of the current CDD release)
Transforming growth factor beta type I GS-motif
This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
Links
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Statistics
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PSSM-Id: 518307
Aligned: 13 rows
Threshold Bit Score: 29.1142
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3MDY_A        10 SLRDLIEQ-SQS--SGSGSGLPLLVQRTIAK 37  human
XP_009025657 402 TMKGLIDQ-TST--SGSGSGAPLLAQRTVSR 429
XP_004074823 202 SLKDLMEH-TRSigSGSGSGLPLLVQRTIAR 231
XP_046441157 217 TIKDMVDH-SQS--SGSGSGLPLLVQRTIAK 244
XP_069043487 164 TYGDMFDE-FCT--SGSGTGLPYLVQRTVAR 191
EDW47022     291 TIHDIIE--MTT--SRFGFGLPLLVQRSIAR 317
EEC15972     179 TIKDMM-E-MTT--SGSGSGLPLLVQRSIAR 205
XP_032524110 240 TLRQYLEG-SAT--SGSGSGQPLMVQRTLAK 267
EDO30434     152 SLCDLITNaDIS--TGSGSGLPLLVQRTVAR 180
XP_008102181 173 TLEDLMED-DCT--TGSGSGLPFLVQRTVAR 200
Q4H2Q1       171 GHNEMMENwSSLagTSSGSGMPLLVQRTISR 201 vase tunicate
NP_001093904 173 NMQDLLDD-KDFstTGSGSGLPLLVHRTIAR 202 vase tunicate
NP_001071834 208 TLADWME--SAT--SGSGSGLPFLVQRTMAR 234 vase tunicate
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