6QB5


Conserved Protein Domain Family
STAG
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pfam08514: STAG (This model is not part of the current CDD release)
STAG domain
STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.
Links
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Statistics
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PSSM-Id: 518306
Aligned: 98 rows
Threshold Bit Score: 77.9912
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6QB5_C         79 GDYPLTMPGPQWKKFRSNFCEFIGVLIRQC-QYSIIY--DEYMMDTVISLLTGLS-----DSQVRAFRHTSTLAAMKLMT 150  human
XP_004364425  350 GEYPLAASGTEFRRFKSGFPDFLHRIFSRC-TGDLLH--DQALIDVAITWLSALS-----TAHIRAFRHTATAACLEICS 421 
Q19555        184 ADYPLVHGGS-LKKVRANLHNFIHTLIIRT-KASMLF--DSNLMDGFVQLLTGMA-----DSQVRAFRHTATFCAMKITS 254  Caenorhabditi...
Q54QR0        107 QHYPLGNKRS--KILIENFNQFWSELVEKC-KKSIIF--DNYLLDMVALWLHELS-----FAAKRGIRHVATQAAIQITS 176  Dictyostelium...
XP_004359027  259 STFPIGGKKA--KGLHNLFIEFFRAIYAKC-QTSIFFehEAYLLNMVIPWTNKLG-----MFKVRGVRYASTLAAIQLAN 330 
XP_001415613  151 GDDPLAKRSRDFKGFRENFLDFIDKCIRDAsEGGELY--DGTLFATLAEIVSTCA-----GSKARPLRMAATMMGLQMIS 223 
Q01FV9        149 GEDPLAKRSQDFKGFRENFMEFTDKLIKDTaEGEELF--DGRLYASVAEIVTTCA-----QCKARPMRAAATMMGLQIIT 221  Ostreococcus ...
EFJ20861       72 VEDFVTSKQKDLRGFKDNLTLFWDTFVLEC-QNGPLF--DEQLMEMCINFVTALSwqvkkNTPPRHFRHVSTLIGLQLAT 148 
Q60D95        140 VEDNYNTKQKDLKNFKENLVSFWDTLVHEC-QNGPLF--DGSLFQKIKDYVVALS-----CTPPRVYRQVASLVGLQLVT 211  Japanese rice
XP_003521521  150 VEDYQNSKKKEIKNFKENLESFWDNLVREC-QHGPLF--DQVLFDKCMDYIIALS-----CTPPRVYRQVASLMGLSLVT 221 

6QB5_C        151 ALVNVALNLSIHQDNTQRQYEAERNKmiGK-RAN----ERLELLLQK 192  human
XP_004364425  422 ALVTAVKTVHAALDNSQRQLETERSK--RG--ANsssaAQLERRIEN 464 
Q19555        255 ALVDVTIELTQSKEKTSKQIEAEKAK--LK--NNsagnEKYEALVAQ 297  Caenorhabditis elegans
Q54QR0        177 SLISICNDLRKDLNVTTRQLAGETK-------NS----SRQKQLKDN 212  Dictyostelium discoideum AX4
XP_004359027  331 TLIKLWAQIKQDLTLTRQRLAKENK-------ES----ESFEQYKKN 366 
XP_001415613  224 SLITVVNNLQKARDLKQNQVDIELKK--KK-SGG----EVVKSLKRQ 263 
Q01FV9        222 SLISVVNSLQSTRDLKQNQLDNETKK--KNgVDA----EIVKSLKRS 262  Ostreococcus tauri
EFJ20861      149 SFVTVAKTLSQSRETKQRQLIAEEKK--KR-KDA----ARIESLNKV 188 
Q60D95        212 SLISVAKTLSGQRETTQRQLNAEKKK---Q-TDG----PIVESLNKK 250  Japanese rice
XP_003521521  222 SYITIANMLRAQRETTQRQLEAEKKK---R-TEG----PRVDSLKKR 260
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