Conserved Protein Domain Family
DUF1746

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pfam08508: DUF1746 (This model is not part of the current CDD release)
Fungal domain of unknown function (DUF1746)
This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.
Statistics
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PSSM-Id: 518302
Aligned: 60 rows
Threshold Bit Score: 79.145
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001528055  48 SIQVVEVVLIIIIYLRDVS-FFKLIIRYVVHLSIKAIDPHHIIQNfGmsgqnaslsgehrrsMVKISLRGLLLGNLFCLL 126
XP_001387587  46 tVQYLGFILLAIVYLRDLS-MVQLGMRAFSQFSISNPFPTahnills---------denkraISKFLLVGIIMGNGLCII 115
XP_001482297  46 sflALGYILLGIMYLRDNS-LVLLVVKFNMHYRVSLCRGNGKETStD---------------EAMMIGQRTIATYLFSLA 109
XP_002619750  40 lmgtLGYVFIAMAYLRDFS-LVLFILRCTLQFLLSEPFPNvgpefgs--------tfnikegQARFLMRSVLIFNGICLF 110
XP_013933100  33 rLDVSCYLALIILYLADEN-LILLLLRGFQQFMLGHPPNSieasavl--------tpaiqriLAQKVLSLGLAFNVLGLI 103
KDE05342      93 SLDAIIWILFVHSYLLSPShLLTFLLRLFSHVQFSSSRKIHPARSlC------------------HLLSVWFFVNASSVI 154
XP_011390919  11 SLDLLCFILFVYIWLLDNC-TVPLIIRAALQVQFCNPSLMHPTWTlP------------------FFVVFLCCLNLIFAL 71 
EST08862      11 SLDLLCYVLFVYTWLLDNR-TLSLLFRAVLQWQCHNSIHIQPTWTlP------------------FLVVFLSGINGIFAL 71 
XP_012188369  11 SLDLLCFVLFVYTWLLDNR-TFLLLVKAALQVQFCNPLQICPTWSlP------------------FIVVFLCSLNLTWAL 71 
GAC77680      78 SLDLLCFVLFVYTWLLDNR-TLLLLIKSALQVQFCNPLQLHPTWSlP------------------FFVVFLACLNALLAL 138
XP_001528055 127 SHLLLGVRTQKVGvfGDE-YSYGGMNVMFIGEKLPSSRFE----IVAFDLAIFATQLI 179
XP_001387587 116 IHILFGRYSKSPY--PDG-YLYGGLTVQFIGERIPYSTWE----LLALDVLVLGVQLV 166
XP_001482297 110 YHLIFGVFKTY----TNDhLLHGSLTLQFIGESPASSRFE----LIFYDIITFAV--I 157
XP_002619750 111 VHLIFPLPVSPL---PSGhYYYGSSSMQFIGESAPCTSWG----ILAYDVATFFLQLV 161
XP_013933100 104 VHIAFSARGGL----GQG-ISYGAYIINIMGENRFEGWFHkllyLLLWDFVLVALQfs 156
KDE05342     155 VHAWQGSRGTK----GTKrWSSTGLIVDFVGQAITPSKSH----LVLLDLLIALSQFV 204
XP_011390919  72 AHLWAPPSTTN---------AGTAILIDFVGHTTLPGRLH----MLFIDALVWFVQLV 116
EST08862      72 AHLWSPPSITN---------TGEALLIDFVGHSYLPGRLQ----VLTIDMGIWFIQLL 116
XP_012188369  72 VHLWTPASKTN---------TGESILIDFVGHTTLPGRLH----MLLIDAVVWGAQLL 116
GAC77680     139 AHLWAPASATN---------RGDAILIDFVGQDAAPGRLH----MLGIDLCVAAVQLL 183
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