3F6G


Conserved Protein Domain Family
LeuA_dimer
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pfam08502: LeuA_dimer 
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LeuA allosteric (dimerization) domain
This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyzes the first committed step in the leucine biosynthetic pathway. This domain, is an internally duplicated structure with a novel fold. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich.
Links
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Statistics
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PSSM-Id: 400689
Aligned: 52 rows
Threshold Bit Score: 98.3966
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3F6G_A   1 KVLTIKSCNIHSGIG-IRPHAQIELEY----QGKI------HKEISEGDGGYDAFMNALTKITNRlGIsipKLIDYEVRI 69  Leptospira interrogans
Q8UD63 440 ARIKFVDHHTYPAGD-FKGVRIVAAEIt--dNGEV------KRIEGKGTGPIDGFINALSVYLGV-DL---SVNDYSEHS 506 Agrobacterium fabrum ...
Q97MC5 440 SPYYLKNYKIHSIQNiEEEKNTVDIEAvisvNGKD------TSIEGVGNGPVDAFFNAMNNKKYN-GC---KFISYDEHA 509 Clostridium acetobuty...
Q8KAP9 441 EPYLMKKCTISWSDEdPDRNDEVATIV----SASMvgpqgeFSFRAKGNGPLDAFVRGMVSHTGI-DF---HVDEYAEHA 512 Chlorobaculum tepidum
Q88P28 441 APYALVSHRLQE----ENGHSAVEVEV----AGEGet---tLHWRGKGNGALEALVAGLPIAV--------EIMDYNEHA 501 Pseudomonas putida KT...
Q12166 477 IYVTLLNYEVKKLNP-ERRALVGQVEI----NDKV------VNIEGYGNGPISSLVDALSNLLNV-KL---SVQNYSEHS 541 Saccharomyces cerevis...
O59736 462 GRFSVNDYTLSSNGP-QSKCIKCVVDI----KGEKkdtpsrVVIEGVGNGPLSALVDALRRQFNI-SF---DIGQYSEHA 532 Schizosaccharomyces p...
Q9CB76 493 QPLERIKQRVNAAEE-DGGSTSIAATVk--iNGEE------TEISGVGNGPLAAFIDALGH-VGL-QV---AVLDYSEHA 558 Mycobacterium leprae TN
P42455 492 APVEQIALRVENAQT-ENEDASITAELi--hNGKD------VTVDGRGNGPLAAYANALEK-LGI-DV---EIQEYNQHA 557 Corynebacterium gluta...
Q8G6Z2 512 GRLKLLKVAVSSGED--GSDTVLKARLldrgVNVGvdapveREVSGIGNGPIAAFLNAISN-FGV-DA---SIMDYVEHT 584 Bifidobacterium longum

3F6G_A  70 PPGGkTDALVETRITWNksldlEEDQT--FKTMGVHPDQTVAAVHATEKMLNQIL 122 Leptospira interrogans
Q8UD63 507 LQHG-SNASAIAYVEMEh----PGGK---LFGAGVNTNIVAASLEAIVSAANRVL 553 Agrobacterium fabrum str. C58
Q97MC5 510 LNIG-SHSKAVAYVQIEs----QDKK---YFGVGISDNIDTASINAIVSALNRSK 556 Clostridium acetobutylicum ATCC 824
Q8KAP9 513 IGHS-SDAMAIAYIRLSf----DDVAL--VCGSGIDSNISLASIKAIVSALNRYK 560 Chlorobaculum tepidum
Q88P28 502 IGAG-TNAKAAAYIELRv----AGGRP--VHGVGIDENITTASFKALFSALNRSL 549 Pseudomonas putida KT2440
Q12166 542 LGSG-SATQAASFINLSyikdiNNHATsnMWGVGVSEDTGDASIKAVFATVNNII 595 Saccharomyces cerevisiae S288C
O59736 533 IGSG-NGVKAASYVEIIf----NNTS---FWGVGIDADVTSAGLKAVMSGVSRAS 579 Schizosaccharomyces pombe 972h-
Q9CB76 559 MNAG-DDAQAAAYVEASv----HGHT---AWGVGIAPSITTASLRAVVSAVNRAM 605 Mycobacterium leprae TN
P42455 558 RTSG-DDAEAAAYVLAEv----NGRK---VWGVGIAGSITYASLKAVTSAVNRAL 604 Corynebacterium glutamicum ATCC 13032
Q8G6Z2 585 MSVG-TDAMAASYVECQvgeadDAQI---VWGVGIDSSITTSALKSIISAINRFQ 635 Bifidobacterium longum
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