Conserved Protein Domain Family
VIT

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pfam08487: VIT (This model is not part of the current CDD release)
Vault protein inter-alpha-trypsin domain
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.
Statistics
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PSSM-Id: 518287
Aligned: 257 rows
Threshold Bit Score: 70.986
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_020431418   58 LKSMTINANVTDTCSLTKVEQRYGalhpNDSTLKigddsnFEAVYSLLLPPYAAISSLEVEYEGKLLVATIKEKETAANE 137 
WP_014006525   41 LQSLQVSGEISGGMAQTTVQMVFF----NPNRRL------LEGQLQFPLLDGQQIVGFSLDIEGRQRPAVPVEKAKGRQI 110  Collimonas fu...
WP_008512768   39 LQQLKIDVAIYGNISRTTWQMTFA----NSTSRV------LEGTLTFPLKDGISVSRYALDINGKIREAVPVDRGKGAVV 108  Mucilaginibac...
WP_014084189   35 MNKMITNVKIVGNIAYTTTEMHFV----NTSNRQ------MEAALVFPLPEGVTVSRYAIDINGKLRESVPVNKNKGKQV 104  Flavobacteriu...
WP_012863408   39 LDTMSVNVEINGDISVTTYDMTFY----NPNTRI------LEGEFSFPLQEGQKVTRYALDVNGKLREGVAAEKEKARTA 108  Sebaldella te...
WP_012862486   46 LDSMKISAEIKRNISTTTYELTFY----NPNSRI------LEGEFEFPLLNGQTVTGYALDINGKMRDGVVVEKEKARQT 115  Sebaldella te...
Q21GR2        134 IPKVAIHTEITGRNAKTTVELSVT----HATDQT------YEAMLRFPLPSSATLTAYALDVEGVMIDSVAVEKARARQV 203  Saccharophagu...
WP_012798819   37 LAELNLEAHVSGLYAQVTQTLVIA----NPNNRS------LSVSVTVPMPDRAVVCGYALDIDGQLIDGVVVPKEKARVA 106  Slackia helio...
XP_002681249   76 LVSHRVQCHVTYPIVQVVSTMTFC----NQNQKT------IEGELLLPMPDGATLIGYAMEVDGQLIDAVPVPKEKAKEV 145 
XP_002674298  113 LVSHHVKCHVTYPIVQVVSTMTFN----SPHGKT------IEGELVLPMPDGATMMGYAMEVNGKLVDAVPVEKEKAKAV 182 
XP_020431418  138 YNDAIASGNSAFLASKSQ--SGQFQVSLGNIDIRSSVVVRFTV 178 
WP_014006525  111 FEAIERRRVDPGLLEATQ--GNNFKLRIYPIPANGTRTVEIKY 151  Collimonas fungivorans
WP_008512768  109 FESIERRRVDPGLLEKVE--GNTFRTRIYPINPNSTRTVTIGY 149  Mucilaginibacter paludis
WP_014084189  105 FEAIEHRRVDPGLLEKVD--GNNFKTRIYPILPNTERIVVIGY 145  Flavobacterium branchiophilum
WP_012863408  109 YENTIRQKIDPGIIEKTA--GNNYKTRIYPIPSNGYKRVVIAY 149  Sebaldella termitidis
WP_012862486  116 FEAVERQNIDPGILEKTK--GNNYKTRIYPIPANGYRKIRITY 156  Sebaldella termitidis
Q21GR2        204 FELIEDENIDPSLVELTN--SNELAIEIYPINQGQPRSIRFTY 244  Saccharophagus degradans 2-40
WP_012798819  107 FETEQRRGADPGLVESVK--GNAYQTRVYPVPGHGSRTVRLTY 147  Slackia heliotrinireducens
XP_002681249  146 FEAEVRAGNKVSMVEKVSq-SNSFKTRVYPLPYNKDKTIQVKY 187 
XP_002674298  183 FESEVRAGGTVSIVEKLTqaSNCFKTKVYPMHPNQDKTVQVKY 225 
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