6HLU,4DJT,2EW1


Conserved Protein Domain Family
Roc

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pfam08477: Roc 
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Ras of Complex, Roc, domain of DAPkinase
Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.
Statistics
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PSSM-Id: 400669
View PSSM: pfam08477
Aligned: 169 rows
Threshold Bit Score: 88.7619
Threshold Setting Gi: 1207167200
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6HLU_A        482 KVHLIGDGMAGKTSLLKQLIG--ETF--DPK--ESQTHGLNVVT--KQApN-I-K--Glend-delKE--CLF--HFWDF 544  Chlorobaculum...
TDH16768      631 KMLVIGPPRQGKTALLEALQT--GRV--APF--TPAECSISTST--WELdK-P-N--Ggkn---skdS--VAF--NVWDI 691  yellow perch
6_pfamImport    1 KLMLIGDPRAGKTTLLHSLM---KTR--SRK--RSLISGYSGATpdKEVtT-L-AtvGvdvnewklKHknKLYsvSAWDF 71  
XP_014347483 1230 KLMIVGNAGSGKTTLLQHLMRc-KHS--DVR--EKATVGIDVKD--WVIp--V-K--Vkv-----kKE--LIL--NVWDF 1288 coelacanth
XP_015706993 1339 KLMIVGNTGSGKTTLLQQLMKckRTE--LGC--PKATVGIDVKDw-----I-I-Q--Gkgk---mkKE--LIL--NVWDF 1398 Japanese quail
XP_008109800 1348 KLMLVGNTGSGKTTLLQQLMK--CRR--PDLglQNATIGIDVND--WKIp--V-R--Gkv-----kKD--VVL--NVWDF 1407 green anole
XP_013004740 1401 KLMIVGNTGSGKTTLLQQLMK--TKK--SDLgvQGATVGIDVKD--WPI-Q-I-K--Gkk-----kKD--LVL--NVWDF 1460 domestic guin...
XP_021326175 1352 KLMVLGGSGSGKSSLIQQLMR--LRR--SQW--R-SDPGVSIRD--WPV-----Rsk-------dkRN--MML--NVWEF 1406 zebrafish
KAE8616199   1328 KVLIVGNTGSGKTTLVQQLMK--CRRleHGA--EKATVGIDV----KDWpIlI-R--Gki-----kKE--ITL--NVWDF 1387 tropical claw...
XP_012815033  605 KMIIVGPPRQGKSTLFEVLQS--GKV-------SQQMQGDNSIR--TTCwE-LqK--Pvgtt-akvDS--VQF--HVWDV 665  tropical claw...
6HLU_A        545 GGQEIMHASHQFFMTRSSVYM----LL----LD-----SRT--D----SNKHYWLRHIEKYGGKSPVIVVMNKID---E 601  Chlorobaculum ...
TDH16768      692 GGQASMSTVNQCFFTDKALYV----VIwnlaLG-----EEA--V----ANLQTWLLNIEARAPNSAVVVVGTHLD---L 752  yellow perch
6_pfamImport   72 AGQEDFYATHPCFLSERAMYI----AV----YD-----ASR--SlkelQTLKPWLAAVHARASHCPVLIVGSHAD---R 132 
XP_014347483 1289 AGQEEFYSTHPHFMTQRALYL----VV----YDls--kGATevD----AI-KPWLFNIKARASSSPVILVGTHLDvsdE 1352 coelacanth
XP_015706993 1399 GGQEEFYSTHPHFMTQRALYL----AV----YDlskgqAEV--D----AMK-PWLFNIKARASTSPVILVGTHLDvsdE 1462 Japanese quail
XP_008109800 1408 AGQEEFYSAHPHFMTQRALYL----AV----YDlsk-geAE--V----DAMKPWLFNIKARASSSPVILIGTHLD---I 1468 green anole
XP_013004740 1461 AGREEFYSTHPHFMTQRALYL----AV----FDls-kgQAE--V----DAMKPWLFNIKARASSSPVILVGTHLD---V 1521 domestic guine...
XP_021326175 1407 SGGEECSGIHPHFMSSRAVYL----VL----YDls-kgASE--I----HAIKPWLFNIKAVAGQCPVIVVGTHADlcee 1470 zebrafish
KAE8616199   1388 AGQEEFYCSHPHFMTPQALYL----VV----YDlskgvSEV--D----AIK-PWLFNIKARASSSPVILVGTHLDvsdE 1451 tropical clawe...
XP_012815033  666 GGSNAMSAVNQCFFTDKALYVvvwnLA----LG-----EEA--V----ANLQFWLLNIEAKAPNAVVLVVGTHLD---F 726  tropical clawe...
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