7JPK


Conserved Protein Domain Family
VGCC_alpha2

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pfam08473: VGCC_alpha2 (This model is not part of the current CDD release)
Neuronal voltage-dependent calcium channel alpha 2acd
This eukaryotic domain has been found in the neuronal voltage-dependent calcium channel (VGCC) alpha 2a, 2c, and 2d subunits. It is also found in other calcium channel alpha-2 delta subunits to the C-terminus of a Cache domain (pfam02743).
Statistics
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PSSM-Id: 518279
Aligned: 12 rows
Threshold Bit Score: 760.782
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JPK_F        646 YSETLKPDNFEESGYTFLAPRDYCSDLKP---SDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQnYW 722  rabbit
9_pfamImport    1 ISESMQLENFNENGYTLIAPREYCKDLKP---SENRTQFLMDFNEFIDRKTPNNPTCNAMLVNRLLLDAGITSELVQ-HW 76  
2_pfamImport    1 FSESLMADKFDEYGYTFIAPRMYCKDLKLpdkNQNNTEFLMEFNDYIDTKTPNNPMCNVELVNRLLLDAGITSSLIK-HW 79  
6_pfamImport    1 FSESLLSDKFDEYGYTFIAPRMYCKDLKPpdkETNNTEYLMDFNNYIDTKTPNNPMCNVELVNRLLLDAGITSDLIK-IW 79  
XP_023808266  626 FSETLLVDKFDEYGYTFIAPRTYCKDMEPl-nKYTNTEFLVMFNDYIDRRTPNDPECNVELMNRLLLDAGITADLIK-IW 703 
XP_025755349  628 FSESLMADKFDEYGYTLIAPRDYCKDLKP---DANNTEFLKRFNDYIDRKTPNNPMCNVDLVNRLLLDAGITSDLIK-IW 703 
XP_002935678  631 YFESLLPNNFELEGRVFLAPRQYCKELEQ---SDNNTEFLENFISLMEKVTPDSKHCDSFLLHNLILDTGITRDLADrVW 707 
XP_064422498  513 yFESLLPNSFESDGHVFIAPREYCKDLDL---SNNNTEFLENFIALMEKVTPDSKQCNNFLLHNLILDTGITRQLAErVW 589  coelacanth
NP_006021     662 YFEFLLPSSFESEGHVFIAPREYCKDLNA---SDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVErVW 738  human
XP_011612267  632 YFEALLPNSFESEGHVFIAPREYCNDLEL---SNNNTEFLLNFIALMEKVTPDSKQCDSLLLHNLILDTGIIQQLVDkVW 708  torafugu
XP_029698141  626 AMETLQLERFDEYGYTFISPREYCKELKL---SLNNTQFLLDFNQYIDRYTPN--ACNVSLVSRLILDAGLTAELVK-VW 699  torafugu
NP_001038425  625 FSESLQVDKFEEYGYTLIAPRDYCEDLKAq--NENMTQFLIDFNEYIDVKTPNDPQCNMDLMNRLLLDAGITAELVK-HW 701  zebrafish
7JPK_F        723 SKQKNIK--GVKARFVVTDGGITRVYPK---EAGENWQENPETYEDSFYKRSLDNDNYVFTAP-YFNKSGPG--AYES-- 792  rabbit
9_pfamImport   77 KKQSLKNrtGVVARFVATDGGITRVYPK---SAGEDWKESAETYEASFYKRSLDNDFYIFTAP-YFNNSGSGesGFDS-- 150 
2_pfamImport   80 KTTESQH--GVLARFVATDGGITRVYPKrfhSAGQYWEKEAETYESSYYKRSLDNDLYIFTP------------SSED-- 143 
6_pfamImport   80 KRNELQQ--GVIARFVATDGGITRVFPK---SAGLDWKEDAETYESSFYKRSLDNDVYIFTPTr----------CTESdn 144 
XP_023808266  704 KKSELPN--GVKAVFVATDGGITRVYPE---SAGMEWNEEVETYESSFYKRSLENDLYIFTPK-PYNKNLSSseSDES-- 775 
XP_025755349  704 KENDPIN--GVMSRYVATEGGITRVYPT---SNGLDWTGQAETYDLSFYKRSLDNDLYIFTPT-VFQNSSQ----YEG-- 771 
XP_002935678  708 KDKDLLTy-GLLAVFAATDGGITRVFPN---KAADDWIEDLEPHNATYYRRSLDNKGYIFRAP-YKESGYRPseLENNtv 782 
XP_064422498  590 KDRDLHTy-GLLAVFAATDGGITRVFPN---KAAEEWEENPEPYNASYYKRSLDNKGYVFKALyREPNNYAPfdAMNDti 665  coelacanth
NP_006021     739 RDQDLNTy-SLLAVFAATDGGITRVFPN---KAAEDWTENPEPFNASFYRRSLDNHGYVFKPP-HQDALLRPleLENDtv 813  human
XP_011612267  709 KNKDLNTy-GFLAVFAATDGGITRVFPN---KAAETWEEDPEPFNASFYRRSLDNKGYIFRAP-YRSARDDFlsPENDti 783  torafugu
XP_029698141  700 SEQTM-D--GIVARFVATDGGVTRVYPR---SVGEDWIENPETYESSFYKRTLDNDVYIFTAP-SFNTENKd-sFSES-- 769  torafugu
NP_001038425  702 NKNQLSD--RIKAKFVATDGGVTRVYPA---SAGSEWTGQAETYESSFYKRSLDNDLYVFTPL-PFTg-----nKTEE-- 768  zebrafish
7JPK_F        793 GIMVSKAVEIYIQGK---LLKPAVVGIKIDVNSWIENF----TKTSIRDPCAGPVCD--------CKRNSDVMDCVILDD 857  rabbit
9_pfamImport  151 GILVSRAVDLTIDGK---KMKPAVVGVKISIAEWMANF----TNATIRKGCNSEICG--------CEKNSKLVDCVILDD 215 
2_pfamImport  144 SVLVSKAVNLKVDDVwllCLIP-VVGVKLDIGAWMESF----INTTQKSNCNDEICG--------CQRNNANIDCVILDD 210 
6_pfamImport  145 DVLVSRAVNLEINNI---TLKPAVVGVKLDIDSWMESF----INITYRMNCKDEICG--------CKKGDQYIDCVVLDD 209 
XP_023808266  776 -ILASKAVDLKIGEV---LLKPAVVGVKLDIKAWMNSL----MNTTTTINCKDEICG--------CRINNAYIDCIVLDD 839 
XP_025755349  772 SVLVSKAVNLKIDDI---TLKPAVAGVQLDIDMWREIF----SNTSQRKSCKDELCG--------CTIGDKNLNCYILDD 836 
XP_002935678  783 GILVSTAVELDIMGK---KLKPAVVGVKLDLESWVEKFkvlaSNQSERHPQGPHKCSpsascemdCDVNDEELLCVLIDD 859 
XP_064422498  666 GILVSTVVELNMNGK---TLKPAVVGVKLDLEAWVSKFkilaSNQT--DPSGPQKCEpsascemdCDAYNNDLLCVLIDD 740  coelacanth
NP_006021     814 GILVSTAVELSLGRR---TLRPAVVGVKLDLEAWAEKFk--vLASNRTHQDQPQKCGpnshcemdCEVNNEDLLCVLIDD 888  human
XP_011612267  784 GILVSTAVEIAVGGK---TIKPAVVGVKLDLEAWTDKFki-lASNHTD-RHTSNTCGpnrgcemdCEANSDELLCYLIDD 858  torafugu
XP_029698141  770 GILVSKAVELTIDEV---TLKPAVVGVKLNVSFWMNSF----MNATLKLNCKDEICG--------CLRNDKHVDCVILDD 834  torafugu
NP_001038425  769 SVLVSRAMDLRIDEF---WLKPAVVGVKLDVQSWMESF----MNTTITPKCEGEICG--------CRRNDEYLDCVLLDD 833  zebrafish
7JPK_F        858 GGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILQIGWWAT 937  rabbit
9_pfamImport  216 GGFLLMSNQDEYIDEIGWFFGEIDPILMTNLVNTSLYAFNKSYDYQSVCDPDRGPKAAAGLRSVFVPTIADILNIGWWAS 295 
2_pfamImport  211 GGFLVMSNRDEHIDEIGRFFGGIDPILMVNLVNSSLFTFKKTFNYQSLCHPEKESKAAAGLRSVYVPTVADILNLGWLAS 290 
6_pfamImport  210 GGFMVMSNQEDYVNQIGCFFGIIDPDLMRTLVNSSLFTAKSTYDYQSLCEPKRESKAAAGLRSIYVPTIADILNLGWWAT 289 
XP_023808266  840 GGFLVMSNQEEYIKEIGNFFGVIDPTIMRALVNDSLYTSKSTYDYQSLCDPKRTSKKAAGPRSVYVPTIADILNLGWWAT 919 
XP_025755349  837 GGFLVMTNQIDHFNEIGKFFGEIDPCIMRSLINSSLYTNKSTYNYQSLCDPKKEDKTSAGMRSVYVPTIADVLNLGWWAT 916 
XP_002935678  860 GGFLVMSNQQDHWSQVGKFFSEVDPNLMSALYNNSFYTRKESYDYQSVCAPKTESNKGAAPRGIFVPTIADVLNLAWLTS 939 
XP_064422498  741 GGFLIMSNQREHWNQIGMFFSEVDANLMHALYNYSFFRKKESFDYQSVCTPKAESNTGAAPRGVFVPTIFDFLNLAWWTS 820  coelacanth
NP_006021     889 GGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTS 968  human
XP_011612267  859 GGFLIMSNQKDDWNKVGMFFSDVEPYLMFALYNNSFYNMKQSYDYQSVCERLPNSEAGSAPRGVFVPTIADFVNLAWWTS 938  torafugu
XP_029698141  835 GGFLLMSNQDEYISLIGQFFGEVDPVLMINLVNTSLYSFNKTYDYQSVCDPEKDSKAAAGPRSVYVPSIADLLSIGWWAS 914  torafugu
NP_001038425  834 GGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPTIADILNIGWWAS 913  zebrafish
7JPK_F        938 AAAWSILQQFLLSLTFPRLLEAADMEDDdfT-AsMSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLI 1016 rabbit
9_pfamImport  296 AAAWSIVQQLFVSFTFPNFLEAADTEEE--QtAaLSKESCITEQTQYYFDNNNKSFSGVLDCENCSRIYRAEKLPNTNLL 373 
2_pfamImport  291 AAAWSIMQQLLVSITFPNFLDAAEMDDE--PsDaKGQEVCIKEQTQYYFENNVTSFGGTIDCENCTRLYHAEKLPKTNLV 368 
6_pfamImport  290 AAAWSIVQQLLVSITLPNVLDAAETDDQ--VsDaMSKEVCITEQTQYFFENDETSFGGLFECANSTRQYLAEKVPNTNLV 367 
XP_023808266  920 AAAWSVLQQLMVSITYPSFLDAVDVEDK--MpDsMTKEVCITEQTQYYFENKRSTFSGSVDCGNCSRLFLAEKLPKTNLV 997 
XP_025755349  917 AAAWSIMQQLVVSITLPNFGEAAT---Dd-ApD-VEKEVCIKEEYQYYFENDSLSFRGVIDTEKCSRLYHAERLPKTNLV 991 
XP_002935678  940 AAAWSLFQHLLVSVIYGSWLQADDIAAEn-M-E-PREASCIMKQTQYYFGNINSTYSAVIDCGPCSRYFHAQRLSNTNLL 1016
XP_064422498  821 AAAWSLLQQLMYGLAYNSWFRADDVTADg-L-D-LRETSCIMKETQYFFSNTATSFNNMIDCGNCSRLFHAQRLANTNLL 897  coelacanth
NP_006021     969 AAAWSLFQQLLYGLIYHSWFQADPAEAEg-SpE-TRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLL 1046 human
XP_011612267  939 AAAWSLFQQFIYGLAYQSWFIRDEARAEg-F-D-SKERSCVMIQTQYYLSNLSSSYNILQDCGNCSRLIHAKRINNTNLL 1015 torafugu
XP_029698141  915 SAAWSILQQLLVGLLFPNLLEAAEPADEe-IpDaMFKESCITEQTQYFFDNEERSYSGVLDCGNCSRMYRAEKLPNTNLV 993  torafugu
NP_001038425  914 AAAWSIMQQLFVSITFPNFLEAVDISDEs---EtPSKESCIKEQTQYFFDSNDTTFKGTVDCQNCSRQFIAEKLMKTNLV 990  zebrafish
7JPK_F       1017 FIMVEsKGTC--PCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCG 1074 rabbit
9_pfamImport  374 FLIVDaKETCp-CSSTKPLIQAEQPSKGPDPCDLVHNPRYRKGPEVCFDNDENEDYTDCG 432 
2_pfamImport  369 FIIADaKVTCs-SC-----------ANGPDPCDMAKNPRYRKGPAACFDNNEHEKDPDCG 416 
6_pfamImport  368 LIISDrQQGNsqSCGLGPLVQDEKQSAGPDPCEMALSPRYRKGPIVCFDKTEHEEDPDCG 427 
XP_023808266  998 FIIADaKGTCs-SCVSSKLIQEEQQSDGPNPCEMALSPRYRKGP-ACFDKNQPEKDADCG 1055
XP_025755349  992 FIVAEtEHGC--ECQEKILKQEEQESQGPDPCQLASEPRFRKGPAACFDNNSHDEVMCRR 1049
XP_002935678 1017 FVVAE-KMICs-QCDSMKLDQAETRSEGPEQCDLVQMPRYRKGPHMCFDYNPMEDTSDCG 1074
XP_064422498  898 FVVAD-KLMCn-QCDSMKLIQAKTrSDGPPQCDLVENPRYRKGPDLCFDYNALEDTTDCG 955  coelacanth
NP_006021    1047 FVVAE-KPLCs-QCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCG 1104 human
XP_011612267 1016 FVVAE-KMPCs-VCEIERLSQEEEEYKEDNPCEEMAVPRYRKGPSTCFDNNLSENTSDCG 1073 torafugu
XP_029698141  994 FLITDaKATCl-SCDPRPLRQAEQPSEGPDPCELAQNPRYRKGPDVCFDNNENEDDSDCG 1052 torafugu
NP_001038425  991 LIVADtE-----MCSQM--------SPGPDPCLISQNPRYRKGPMECFDNNVNENNEPCG 1037 zebrafish
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