Conserved Protein Domain Family
RIH_assoc
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pfam08454: RIH_assoc (This model is not part of the current CDD release)
RyR and IP3R Homology associated
This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.
Links
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Statistics
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PSSM-Id: 518270
Aligned: 61 rows
Threshold Bit Score: 71.0258
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004342590 5389 QNDARFVC-HLFRFLQLLCEGHNHEFQSYLRTQPGHV----KSYNLIVCTVDYLLRLQEKfsdlywfyfdkptidaqgrk 5463
2_pfamImport    1 EEEVASLS-ALMEFLRLLCENHYLDMQDYMRRQPDNL----RTYNMVTEVCALLQGLEWVtlddv-----------rhwg 64  
XP_020438262 1888 ATEFLIMS-NIFRVLQLLCQGSSSLFKSYIRCQPDNY----KSYDLLRELCQFLKILETIv------------------n 1944
Q9NA13       2414 STEFQLLQ-NIFRVLQLLCQGTTNIFKKSIRSQPDNY----KSYDILKEMCQFLKILETIv------------------n 2470 Dictyostelium...
XP_004031904 1715 ISEYEIICeRLLKLLQLMCENVNTNFQKFFRKQTDDKiymiSNYNLVLEVSNLLCLFLEDeqlsi--------------- 1779
A0CWY9       2285 NTEYKILClKVLKLLQALCENVNVDFQKFLVRQYDDDsy-qANINIVNEVASLLADLLEKgwsvf--------------- 2348 Paramecium te...
A0DBN2       1844 SQKLGIIN-IQIRFLQLIAEDHFKPAQDFLRIQEGFS----QNYDMIQQLQDILFNHFVQetf---------------in 1903 Paramecium te...
A0DBM4       1867 AMKLGILQ-VQMKLIQLLAEDHYRPFQDFFREQIGFA----QNYDIIQHLMNILLNFFNQesf---------------ya 1926 Paramecium te...
XP_002675454 2049 FEEKGHIE-EILRFLQLMTEGHNNDLQHYLAEQKYNT----QSFNIVEECLNFIVALEKD-------------------- 2103
KAL0145319   1943 TKDYKVMQ-DTMRTLQLMVEGHNLHLQMYLAKQPDNI----KSFNIVLDVVEYFHAVVPL-------------------- 1997 Mucor lusitan...

XP_004342590 5464 LMSQSITIAKQVFESLTEYIQGPcIENQLSLASS-RLWDAVNGFF 5507
2_pfamImport   65 IDARTIDLAFTVVRTLVEFAQGN-EGNKRAIATP-SLTGSINDLF 107 
XP_020438262 1945 IDLDSINLASRFFSCLKEIVKHT-PENQIAVTNV-QMCKAICNIL 1987
Q9NA13       2471 IDSDSIELGLRFFACMKEIVKNT-PENQIAVTNV-QVCKAVCNIL 2513 Dictyostelium discoideum
XP_004031904 1780 --irksNLIMQFLDTLNEFSTGE-NDNQKIICQNkRLFNYINDKI 1821
A0CWY9       2349 --yklqEIYRQALESLVEFSTGF-EENKKELCKNtRLFTLLNQIL 2390 Paramecium tetraurelia
A0DBN2       1904 LSFDDYVLIVGCFDCIKELIQGPcHENQMKICSI-QFLKLCYKLL 1947 Paramecium tetraurelia
A0DBM4       1927 LSQDDYILILNCFDCLKENIQGPcPQNQEKLCQP-QFLRLCGKLL 1970 Paramecium tetraurelia
XP_002675454 2104 ITADNIETAIQCFDSLTEFVQGPcLTTQQVIGMSpKFYFVCNEIM 2148
KAL0145319   1998 CNEQNIELIIQVLDTITELAQGc-LQNQVTIFNN-KIINPVNTIL 2040 Mucor lusitanicus
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