6UQK,5J8V


Conserved Protein Domain Family
RIH_assoc

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pfam08454: RIH_assoc 
RyR and IP3R Homology associated
This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.
Statistics
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PSSM-Id: 400656
View PSSM: pfam08454
Aligned: 66 rows
Threshold Bit Score: 71.7956
Threshold Setting Gi: 124457348
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6UQK_A       1712 TSVLIMQ-PILRFLQLLCENHNRDLQNFLRCQ-NNK----TNYNLVCETLQFLDIMCgsttgglgllglyINEDNVGLVI 1785
A0DBN2       1845 QKLGIIN-IQIRFLQLIAEDHFKPAQDFLRIQeGFS----QNYDMIQQLQDILFNHFvqet------finLSFDDYVLIV 1913 Paramecium te...
A0DBM4       1868 MKLGILQ-VQMKLIQLLAEDHYRPFQDFFREQiGFA----QNYDIIQHLMNILLNFFnqes------fyaLSQDDYILIL 1936 Paramecium te...
CBJ30032     3436 EEVASLS-ALMEFLRLLCENHYLDMQDYMRRQpDNL----RTYNMVTEVCALLQGLEwvtldd--vrhwgIDARTIDLAF 3508 Ectocarpus si...
EFA86157     1889 TEFLIMS-NIFRVLQLLCQGSSSLFKSYIRCQpDNY----KSYDLLRELCQFLKILEti---------vnIDLDSINLAS 1954 Heterostelium...
Q57XB2       2218 LNQRFVC-TLFRMLQLFCEGHNLSMQNYIRSQyDNL----HSVNAVHEVMNLITEIAa-----------vVHPATVRMLQ 2281 Trypanosoma b...
EPB84881     1916 KDFRVMQ-DTMRTLQLMVEGHNLHLQMYLAKQpDNI----KSFNIVLDVVEYFHAIVp-----------lCSEQNIELII 1979 Mucor circine...
EFC42710     2050 EEKGHIE-EILRFLQLMTEGHNNDLQHYLAEQkYNT----QSFNIVEECLNFIVALEk-----------dITADNIETAI 2113 Naegleria gru...
XP_004031904 1716 SEYEIICeRLLKLLQLMCENVNTNFQKFFRKQtDDKiymiSNYNLVLEVSNLLCLFLedeqls--------iirksNLIM 1787 Ichthyophthir...
A0CWY9       2286 TEYKILClKVLKLLQALCENVNVDFQKFLVRQyDDDsy-qANINIVNEVASLLADLLekgwsv--------fyklqEIYR 2356 Paramecium te...
6UQK_A       1786 QTLETLTEYCQGPCHENQTCIvtHES-NGIDIITALI 1821
A0DBN2       1914 GCFDCIKELIQGPCHENQMKI--CSI-QFLKLCYKLL 1947 Paramecium tetraurelia
A0DBM4       1937 NCFDCLKENIQGPCPQNQEKL--CQP-QFLRLCGKLL 1970 Paramecium tetraurelia
CBJ30032     3509 TVVRTLVEFAQGN-EGNKRAI--ATP-SLTGSINDLF 3541 Ectocarpus siliculosus
EFA86157     1955 RFFSCLKEIVKHT-PENQIAV--TNV-QMCKAICNIL 1987 Heterostelium album PN500
Q57XB2       2282 SAFALLTELCQGPCHENQEAL--LGY-GVCVVISKLL 2315 Trypanosoma brucei
EPB84881     1980 QVLDTITELAQG-CLQNQVTI--FNN-KIINPVNTIL 2012 Mucor circinelloides f. circinelloides 1006PhL
EFC42710     2114 QCFDSLTEFVQGPCLTTQQVI--GMSpKFYFVCNEIM 2148 Naegleria gruberi
XP_004031904 1788 QFLDTLNEFSTGE-NDNQKII--CQNkRLFNYINDKI 1821 Ichthyophthirius multifiliis
A0CWY9       2357 QALESLVEFSTGF-EENKKEL--CKNtRLFTLLNQIL 2390 Paramecium tetraurelia
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