P40004 3 NSLKAFALVFGGCCSNVITFETLMSNET-GSiN---------NLITFCQ-----FLFVTCQGLPEFLDVHQp------FP 61 Saccharomyces cere... Q869W7 7 ISLIPISMIMVGCCSNVISLELIMKQSQ-SH-A---------ILVTFFQ-----FATVAFISFFVNIRWKQvfs-ifwIP 69 Dictyostelium disc... Q00974 2 SFVLILSLVFGGCCSNVISFEHMVQGSN-INlG---------NIVTFTQ-----FVSVTLIQLPNALDFSHf------PF 60 Kluyveromyces lact... O74750 1 MIASALSFIFGGCCSNAYALEALVREFP-SS-G---------ILITFSQ-----FILITIEGL-----IYFll----nDV 55 Schizosaccharomyce... XP_965367 79 AIGVMLSLIFGGCCSNVFALESIIKVEP-GA-G---------TLLTFVQ-----FLFVALVGLPSQIDWSRp------PF 136 Q6NMB6 18 KGVFAVSGIMSTLVIYGVLQEKIMR----VPyGvnkeffkhsLFLVFCNrl--tTSAVSAGALLASKK------------ 79 thale cress O64503 13 LLALCISGIWSAYIYQGVLQETLST----KRfGpdekrfehlAFLNLAQsvvclIWSYIMIKLWSN-------------- 74 thale cress Q29Q28 22 QFLICTSGFFFGYLVNGVCEEYVYNRLQ-FSfG---------WYFTFIQgfvylFLIY-LQGFT---------------- 74 thale cress Q20787 41 QFVLLSLAIFILYIGYGYMQELIFKLPGmKPfG---------WTLTLIQ-----FLIYSGCGYTECIIW----------- 95 Caenorhabditis ele... Q9VVD9 61 QFLLSCAGVFFLYILYGYLQELIFTVEGfKPyG---------WFLTLVQ-----FGYYIGFGLVERRLEGYrisggsfWN 126 fruit fly
P40004 62 Y-FKPLKTPLHVYVITVVLFYISSTTNNNVFKYNISIPIHIVFRCFGTVITMFTCWLLNG--RKYTKIQILSTLFLTIGA 138 Saccharomyces cere... Q869W7 70 IgLRERKIPLKTYFLMVSIFFILSVLNNKALDCDIPIPFHMIFRSSSLLSTIVIGSIFYR--KSYSKQQILSLIMVTLGI 147 Dictyostelium disc... Q00974 61 R-LRPRHIPLKIHMLAVFLFFTSSVANNSVFKFDISVPIHIIIRCSGTTLTMIIGWAVCN--KRYSKLQVQSAIIMTLGA 137 Kluyveromyces lact... O74750 56 QsLKHPKVPRKRWFVVVVMFFAINVLNNVALGFDISVPVHIILRSSGPLTTMAVGRILAG--KRYSSLQIGSVFILTIGV 133 Schizosaccharomyce... XP_965367 137 F-LKKNQVPIKRWLINIALFFAINVLNNHAFSYDISVPVHIILRSGGSITTMIAGALWG---KRYSRIQIVAVLLLTVGV 212 Q6NMB6 80 --VLDPVAPVYKYCLISVTNILTTTCQYEALKY-VSFPVQTLAKCAKMIPVMVWGTLIMQ--KKYKGFDYLVAFLVTLGC 154 thale cress O64503 75 --AGNGGAPWWTYWSAGITNTIGPAMGIEALKY-ISYPAQVLAKSSKMIPVMLMGTLVYG--IRYTFPEYMCTFLVAGGV 149 thale cress Q29Q28 75 --TKHIVNPMRTYVKLSAVLMGSHGLTKGSLAY-LNYPAQIMFKSTKVLPVMIMGAFIPGlrRKYPVHEYISAFLLVLGL 151 thale cress Q20787 96 H-NTKRMIPWRIYGVIAFFTVATMGLSNASVGY-LNYPTQVIFKCCKLIPVLIGGILIQG--KRYGWIDIGAAMLMSLGI 171 Caenorhabditis ele... Q9VVD9 127 IePEPRCIPMRTYLILAALTLGTMGLSNSSLGY-LNYPTQVIFKCCKLIPVLVGSILIQG--KRYGLLDFAAATCMCIGL 203 fruit fly
P40004 139 IIASLFKDADFryqdlklqawkiGSDqsvDLT-FIFGICILVLSSFTSSLLSAYNERTYQKYGKHWK-ENIFYSHFLSLP 216 Saccharomyces cere... Q869W7 148 IFATFSSMPDSkkei-----slgHEP---NLLrFSIGMLMLIAAMFLSSILGLIQEHTYKLYGKDRHyETIFYSHLFSLP 219 Dictyostelium disc... Q00974 138 IVASLYRDKEFsmds-----lklNTDsvgMTQkSMFGIFVVLVATALMSLLSLLNEWTYNKCGKHWK-ETLFYSHFLALP 211 Kluyveromyces lact... O74750 134 IIATLGNAKDL-------------HLhveSMTrFGIGFTILVITQILGAIMGLVLENTYRIYGSDWR-ESLFYTHALSLP 199 Schizosaccharomyce... XP_965367 213 ITAAWSDAQSKgs---------sKKEtheKNSdFGIGLAILFVAQSLSAVMGLYTEETYKKYGPHWK-ENLFYSHLLSLP 282 Q6NMB6 155 SVFILFPAGDD------------VSPynkGREnTVWGVSLMAGYLGFDGFTSTFQDKLFKGYNMEIH-NQIFYTTLCSCV 221 thale cress O64503 150 SIFALLKTSSK-------------TIsklAHPnAPLGYALCSLNLAFDGFTNATQDSIASRYPKTEAwDIMLGMNLWGTI 216 thale cress Q29Q28 152 ILFTL-------------------ADaqmSPNfSMIGIMMITGALIMDAFLGNLQEAIFTMNPETTQmEMLFCSTVVGLP 212 thale cress Q20787 172 IMFTL-------------------ADnkvSPNfDSRGYIMICGALLADAVIGNIQEKNMKKYGGSSN-EMVLYSYGIGSV 231 Caenorhabditis ele... Q9VVD9 204 AWFTL-------------------ADsqmTPNfNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSS-EVVFYSYGLGFV 263 fruit fly
P40004 217 LFL-----FSRKQLIHEYRVMRKSERILCsnf---------------ggkILVPREETLLLFNVLTQYFCVKGVNILASK 276 Saccharomyces cere... Q869W7 220 FFL-----LFKDDILHHIQLNNDSALMALpf-----------------gfGSFPTLWVYLIVNVLTQYVCIQGVFILTGK 277 Dictyostelium disc... Q00974 212 LFM-----LGYTRLRDEFRDLLISSDSMdip----------------ivkLPIATKLFMLIANNVTQFICIKGVNMLASN 270 Kluyveromyces lact... O74750 200 FFL-----FLLRPIRSQWNDLFAIHTKGF---------------------LNLPSGVWYLCFNTLAQYFCVRGVNALGAE 253 Schizosaccharomyce... XP_965367 283 LFL-----FFWPSLKTQFKKLANSAPLTLplpdfeeypnlspniqkflenIHIPSQLFYLALNVLTQYACIRGVNLLAAA 357 Q6NMB6 222 LSFtg--lILQGHLLPAVDFVSLHRDCL-----------------------------LDIALLSTVATASQFFISYTIRT 270 thale cress O64503 217 YNMiymfgLPQGIGFKAIQFCKLHPEAA-----------------------------WDILKYCICGAVGQNFIFMTISN 267 thale cress Q29Q28 213 FLFvp--mVLTGEVFRAWTACAQHPYVY-----------------------------GVLVFEAMATFIGQVSVLSLIAL 261 thale cress Q20787 232 FIFaf--vVLSGEVFSAIPFFLENSWKTF----------------------------GYALILSCLGYLGVNVVLTHIKV 281 Caenorhabditis ele... Q9VVD9 264 YLFvi--mLVTGNFFSGFAFCLEHPVETF----------------------------GYGFLFSLSGYLGIQFVLALVRS 313 fruit fly
P40004 277 TNALTLSITLLVRKFISLLLSVRLFDNNLSYTGYIGVYLVFFGAFIYSLGS 327 Saccharomyces cerevisiae S288C Q869W7 278 TSTLTCTLVISIRKFLSIIISVIYFNNHFTSLLFTGTILVFLGTFMYSTSG 328 Dictyostelium discoideum Q00974 271 TDALTLSVVLLVRKFVSLLLSVYIYKNVLSVTAYLGTITVFLGAGLYSYGS 321 Kluyveromyces lactis NRRL Y-1140 O74750 254 TSALTVSVVLNVRKFVSLCLSLILFENEMGPAVKFGALLVFGSSAVYASAR 304 Schizosaccharomyces pombe 972h- XP_965367 358 STALTVTIVLNIRKLVSLLLSIWLFGNKLAFGTLVGAVIVFGAGGLYSLDG 408 Q6NMB6 271 FGALTFAAIMTTRQLASIMLSCIWFSHPLSWEQCIGSVIVFGSLYAKNLLN 321 thale cress O64503 268 FGSLANTTITTTRKFVSIVVSSVMSGNPLSLKQWGCVSMVFGGLAYQIYLK 318 thale cress Q29Q28 262 FGAATTALITTARKGVTLLLSYLIFTKPLTEQHGSGLLLIAMGIVLKMVPM 312 thale cress Q20787 282 FGALVAVTVTTLRKALTIILSFMLFSKPFTIEYVYAGSVVMLAIYLNLYSK 332 Caenorhabditis elegans Q9VVD9 314 SGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSK 364 fruit fly
Jiyao W et al.(2023). "The conserved domain database in 2023.",