Conserved Protein Domain Family
CLCA

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pfam08434: CLCA (This model is not part of the current CDD release)
Calcium-activated chloride channel N terminal
The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N-terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage.
Statistics
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PSSM-Id: 518260
Aligned: 20 rows
Threshold Bit Score: 498.036
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008263168   24 VNLNNNGYDGIVIAINPSVPEDEKLIQNI-----KEMVTDASTYLFQATKRRVFFRNVHILVPITWKSKSEYLMPKQESY 98  
4_pfamImport    1 IQLNGNGYDGIVIAINPSVLEDEKLIQKT-----KEMVTEASTVLFHATNKRAYFRNVSILIPMTWTSKPEYLIPKLESY 75  
XP_006634877   21 IELDGNGFTNILVAINPAVPENPQLIQNI-----KDMINSSSAYLVTATQKMFYFKDVKILVPPNWAPQPSYTRGKTESY 95  
6_pfamImport    1 VKLRNGGYEDVVIGIDPKIAENVKIINSI-----KEMFKEASSFLFHASQQRFYFRTIKIVIPSTWASKPEYGRVSRESY 75  
XP_007480625   24 IKLNGNGYEDVVIAIDPNVPEDEKLIQQI-----EDMISEASTYLYRATEKRFYFESVSILIPKTWQPKSDYEKPKHETY 98  
EHB18742       25 IQLNNNGYEGIVIAIDPTVPEDEGLIQQIkaifpKDMVTEASPYLFEATEKRFYFKSVSILIPQNWKTKPDYVKPKLETY 104 
Q9D7Z6         25 IQLNNNGYEGIVIAIDHDVPEDEALIQHI-----KDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETF 99   house mouse
ELK06311      125 IQLNNNGYEGIVIAIDPNVPEDETLIQQI-----KDMVTQASPYLFEATEKRFYFKNVAILIPETWKTKPEYVRPKLETF 199 
XP_056671370   24 IKLNGNGYEDVVIAIDPNVPEDEKLIQQI-----EDMISEASTYLYRATEKRFYFESVSILIPKTWQPKSDYEKPKHETY 98   gray short-ta...
P54281         24 VNLINNGYDGIVIAINPSVPEDEKLIQNI-----KEMVTEASTYLFHATKRRVYFRNVSILIPMTWKSKSEYLMPKQESY 98   domestic cattle
XP_008263168   99 DQADVIIANPSLKYADDPYTLQYGQCGDKGQYIHFTPNFLLTNNL-SAYGPRGRVFAHEWAHLRWGVFDEYNVDRPFYSS 177 
4_pfamImport   76 EQADVIVADPYLKYGNDPYTLQYGQCGEKGRYIHFTPNFLLGDNL-NIYGPRGKVFVHEWAHLRWGVFDEYNLDQPFYIT 154 
XP_006634877   96 ENANVVIKD--MSYGDDPYTLQYDECGKPGKYIHLTPSFLLNDSLlNAYGPRGRVFVHEWAHLRWGVYDEYNEDTPFYIS 173 
6_pfamImport   76 ENADIIVAEPFVKYGNDPYTLQYGGCGKKGRYIHFTSNFLIDESLvYIYGPRGRVLVHEWAHLRWGVFDEYSNDAPFYST 155 
XP_007480625   99 KNADIIIEVPNSPGNDIPRIDQFGKCGERGERIYLTPRIIRGEML-NVFGPKGKVLVHEWAHFRWGVFEEYNEDNPFYQF 177 
EHB18742      105 KNADVLV-EPNQPGNEEPYTEQVGKCGDKGERIHFTPDFLAGKML-NQYGLQGRVFVHEWAHLRWGVFDEYNNDEKFYLL 182 
Q9D7Z6        100 KNADVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKL-TQYGPQDRTFVHEWAHFRWGVFNEYNNDEKFYLS 178  house mouse
ELK06311      200 KNADVLVAESNPPGNDEPYTEQMGNCGEKGERIHFTPDFIAGKKL-PQYGPQGRAFVHEWAHLRWGVFNEYNNDQKFYLS 278 
XP_056671370   99 KNADIIIEVPNSPGNDIPRIDQFGKCGERGERIYLTPRIIRGEML-NVFGPKGKVLVHEWAHFRWGVFEEYNEDNPFYQF 177  gray short-ta...
P54281         99 DQAEVIVANPYLKHGDDPYTLQYGRCGEKGQYIHFTPNFLLTNNL-PIYGSRGRAFVHEWAHLRWGIFDEYNGDQPFYIS 177  domestic cattle
XP_008263168  178 TKNTIEATRCSTQITGRKVVFReCKGGSCIT-RPCRWDSQTGLYEAKCTFIPDKSQLAKESIMFMQNLDSVTEFCTANTH 256 
4_pfamImport  155 RQNTIEATRCSRNIAGVNRVLK-CSNKSCAI-KMCKTNRKTGMYEAKCQFIPEKSQSAKASIMFMQSLDSVVEFCTKKTH 232 
XP_006634877  174 SSQQVEATRCSKDLTGSLGVPFsSDSSL----QRCSKDQITGLPSANCQFFPDKTQKTSVSIMYLQSLPAITEFCNDKSH 249 
6_pfamImport  156 GANKSEATRCAAGITGQY---R-FQTGTAET-RNCRIQRQTELYEPGCLFIPHIKQTSPVSIMFMQSLPSVSQFCDKSNH 230 
XP_007480625  178 DGKN-VPVKCSEGITGTNKVYT-CSGGSCSI-RDCWTDPKTGKLNKDCMFIPDKVQSEKASIMFMQSIDSVVEFCTEKNH 254 
EHB18742      183 KNKP-EAVRCSADITGKYEEVK-CQGGSCVVgRPCSFDKVTGLYKEGCEFIPHKQQTVKTSIMFAQSIDSVVGFCTEKNH 260 
Q9D7Z6        179 KGKP-QAVRCSAAITGKNQVRR-CQGGSCITnGKCVIDRVTGLYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNH 256  house mouse
ELK06311      279 NGKN-KAVRCSAAITGKNAVNK-CQGGSCVT-TPCRPNRTTGLYGKECEFIPDKEQMEKASIMFSQSINSVVSFCTEKNH 355 
XP_056671370  178 DGKN-VPVKCSEGITGTNKVYT-CSGGSCSI-RDCWTDPKTGKLNKDCMFIPDKVQSEKASIMFMQSIDSVVEFCTEKNH 254  gray short-ta...
P54281        178 RRNTIEATRCSTHITGTNVIVk-CQGGSCIT-RPCRRDSQTGLYEAKCTFIPEKSQTARESIMFMQSLHSVTEFCTEKTH 255  domestic cattle
XP_008263168  257 NTEAPNLQNKMCNHRSTWDVIMDSEDFQNASSMA 290 
4_pfamImport  233 NPDAPNLQNKMCNHRSTWEVIMASEDFRNLSSMR 266 
XP_006634877  250 NQEAPNMQNRMCNYRSVWSVIGSAPDFDRTAPMT 283 
6_pfamImport  231 NLMAPNMQNKMCSYKSTWEVIMNSADFVSSRALG 264 
XP_007480625  255 NRFAPNLQNKMCYLKSTWEVIQDSEDYKKSTPMM 288 
EHB18742      261 NKVAPNMQNQKCNLRSTWDVISDSEDFKKTTPMT 294 
Q9D7Z6        257 NQEAPNDQNQRCNLRSTWEVIQESEDFKQTTPMT 290  house mouse
ELK06311      356 NKEAPNLQNQKCNLRSTWEVIRDSEDFKTTTPMT 389 
XP_056671370  255 NRFAPNLQNKMCYLKSTWEVIQDSEDYKKSTPMM 288  gray short-tailed opossum
P54281        256 NVEAPNLQNKMCNGKSTWDVIMNSTDFQNTSPMT 289  domestic cattle
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