Conserved Protein Domain Family
Vfa1
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pfam08432: Vfa1 (This model is not part of the current CDD release)
AAA-ATPase Vps4-associated protein 1
Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole. There is a CCCH zinc finger at the N-terminus.
Links
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Statistics
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PSSM-Id: 489607
Aligned: 83 rows
Threshold Bit Score: 93.5495
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_022464211   3 NEYIKRRVATKDSQLCMICQKPTTTVLFNQSGq-----DWIYTCELHLQNnPQFVTPSYSQeYHDAVENCKNNREALTKL 77 
Q6CNC3         3 NEYTRKKVSAKDRKACLICGNPTVTVLFNGSGp-----DWFYTCDIHLVDnPQFVQPLYPKeYHESLVSLKPLKERIEEL 77  Kluyveromyces l...
XP_002553775   3 NQYTKRKVAPRDARSCLVCLKPTACVLYNASIq-----DWFHCCELHLQDnPQFAKPVYPAgYQDALGQLAELKRTLDAQ 77 
XP_003648485   3 NVYTKRKVSAASASTCLVCLKPTTTVMYNKSGq-----DWFYCCDLHILDnPQFAQPIYTShYKERLKRVNELGAKLGSH 77 
Q75CH1         2 DKYAKRKVAARDAGGCLICDSRTVTVLHCAASg-----DWFFCCDLHLQDnPQFAQPNYTPaYHAACRRVADLASRLAAS 76  Eremothecium go...
XP_003682116   3 NVYIARQVAAKDMQPCLICSKPTVTVLYNASGp-----DWLYTCDIHLHDnPHFATPIYNDeYQEALDKLKMLKAQVGKL 77 
XP_056087341   6 NQYVARKVALKDMQPCAICSKPSTTVLYNASGp-----DWLYTCDIHLQDnPQFASPIYSTeYNEALGKLKLVKSKIERL 80 
P40080         3 NEYVARKVALKDMQPCAICSKPSTTVLYNASGp-----DWLYTCEIHLQDnPQFVIPLYSTeYNEAVAQLKLVKGKMDSL 77  Saccharomyces c...
XP_003668527   3 NEYVSRKVSLKDINGCLICQKPTTTVLYNKSGp-----DWFYTCDIHLQDnPEFVKPIYGKdYETKTNRLKSVQQELHRI 77 
XP_004180248   3 NEYVKRKVALKDIQPCLICNKPSTTVLFNGDNnngggaDWFYVCDIHLQDnIQFVVPVYSKeYENEVIHLRQLKQKITST 82 

XP_022464211  78 KNNNStDSSSWdtwvn-rlftkKQENdkakpkeseiLNSELPTNTRDDKGSNPTNpaksp-diqsqINDLQGQYDAALEK 155
Q6CNC3        78 QRKER---GTWdqwvn-kifdsKKPS-------------SSDDKKEDRDDASSDDkkktd--eansLEELQQTYQATLDK 138 Kluyveromyces l...
XP_002553775  78 RVHGS---GSWdtwvn-klisrKPKSendkdkepgkEPSKDPDEEPGKGSDKEPSp---------aGDDAACAYQQALDR 144
XP_003648485  78 SATHS---GNWdswit-nlftsAKVAp--------pETKSQPNSEKPPADPADAEpk-------etLSQLKLQYDKELSA 138
Q75CH1        77 EKAAA---AGWdswlg-rfaasKKKPavpakdgnvsAQGQDKTEDKEEKPAEVSAa------------DLRREYERELAT 140 Eremothecium go...
XP_003682116  78 SAADK--PASWdgwvsqifikkPKKDdedanedkdkDKDKDKDKDKDKDKDKELKnqadekkqadsLKECQQKYNQQIDL 155
XP_056087341  81 ASAKN-QIGSWdgwvt-kifskKEKQk------------ANSSENRESTTTETADappevegdpdtLLETQAEYGKILDE 146
P40080        78 TSAQT-QLGSWdgwvt-kifskKEKE-------------TNNSKDPDPTTTDSTDtspqakndaeiLSETKKQYSKILDK 142 Saccharomyces c...
XP_003668527  78 QKNND--PSSWdgwvg-klfikKNKNqs-------pDKDKDKDKDENKDGDNNNNkvgne-stgnrSDMLQREYQTLLDE 146
XP_004180248  83 AAIKN---GNWdgwvt-klfakGTKSstktdnieadSAIDADNEDKGTKGQDTKApa--------dLSALQREYDETLDR 150

XP_022464211 156 MLTLQKSNksFKLSDKMFALRLENRrekqrAQERKRREEENYSNtDPEQmqs-qfsFPEVPK 216
Q6CNC3       139 LAASRETCnrYTLHDLVFQSRVDRLrklaqLKEKKRVEQQSYTNtDPNQllq-sfsFPEVPK 199 Kluyveromyces lactis
XP_002553775 145 VARYRKNLrtYSLSQIMFESRLEAQkraeaLKQRRQREQEAYTNtDPDElqa-kfaFPSVPR 205
XP_003648485 139 VADIKKNTrtYSLSQVMFESRQQRLkhlsnVKEQNRMHQEAYSNtDPEDllk-rynFPELPK 199
Q75CH1       141 VATLRNKPatYTLSAVMLTSRLERRtrvaaRAERAREEEQAYSNtDPQQllq-tyhFPELPK 201 Eremothecium gossypii
XP_003682116 156 VTSLQKKSrkYKLSDVTFNSRVQRKkneriQAERRRKEQEMYSTtDPEEiak-kfaFPTVPN 216
XP_056087341 147 VAELRRTNrkYELAKIMFESRVLKKrtdqlNRERYLKEQENYSNtDPEEllr-khaFPSVPR 207
P40080       143 VTELQRKNrkYELAKIMFESRLLRKrteqvNRERYLKEQENYSNtDPEEllr-khvFPSVPK 203 Saccharomyces cerevisiae S288C
XP_003668527 147 LTHLKQNNrkYQLDNSLYENRVQRR-------IRTQRIKETYTAtNPEElaqrlatFPNVPT 201
XP_004180248 151 ITKLQKNNktYQLSDTFYQSRLERKkqqekLAARRKQLQESYTNtDPDElls-kfaFPSVPK 211
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