5A5U


Conserved Protein Domain Family
Forkhead_N

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pfam08430: Forkhead_N 
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Forkhead N-terminal region
The region described in this family is found towards the N-terminus of various eukaryotic forkhead/HNF-3-related transcription factors (which contain the pfam00250 domain). These proteins play key roles in embryogenesis, maintenance of differentiated cell states, and tumorigenesis.
Statistics
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PSSM-Id: 369872
View PSSM: pfam08430
Aligned: 30 rows
Threshold Bit Score: 34.6298
Threshold Setting Gi: 75023976
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A5U_B   17 SYYADTQEAYSSVpvsnmn----sglgsMNSMNTYMTMNTMttsgn-------mtpaSFNM-SYANPGLGAGLSP-GAVA 83  
Q17135    6 KGYPTGTTMNTMG---------------MNTMSSMGGMNHA----------------SYTGtGPVNPGAYSASAYsGTMN 54   Florida lancelet
Q1PA44   11 PGYPAASPVSMNTmtgmt------gvgsMTSMNSYSSMSTTgmpg--------saitSMSGmTHAGMTGMSSMSS-MAGM 75   purple sea urchin
Q2WBY1   24 SYDPACTSAYS-----------------MNNMGTMSPMNTMgmsam------smtnsMSSAyNAPSLQAIGSMPA-GMGS 79   Dumeril's clam worm
Q8I6T9    8 SYDPTSSGGYSMAsm-----------tsINTMGGVGPMSNMnypsqgmggmhgamssMNTMpPSMGSMGMGGMAA-MHGS 75   common limpet
Q9UAH4    7 ATYPTATATT------------------MSSMGNMGSMNTQ------------------MQySSAMPGGMSSINS-YSMP 49   Ptychodera flava
O16108    8 SKYQTFQQSFTNGmngsv-----pgsysMNPMAIGGPSTLH-----------------SGMnGGYGSGMLNGMNAaAGMN 65   Molgula oculata
Q6DL96    8 SKYQPFQQSYATGmnnmtngmqpsyvnqMNPMSLTAAGNQVg--------------fNQALpQGYGGVSFNGMGT-SAMN 72   vase tunicate
Q9GV73    8 SKYQSFQQSYGASmsnmvnampssyvnsINPMSITGNQMTGi---------------PNPMnQGFPGGALNGMSSvSSMQ 72   Halocynthia roretzi
Q93133    6 SAYEAQGGSPSSMq-------------aMTAMTTGNSYSPS----------------SYTSsGYSVTQSMTTLGS-SYST 55   Florida lancelet
5A5U_B   84 GMPAGSAGAMns----mTAAGVTAMGT-ALSP-GgMGAmgaqpaasmnglgpy-aaamnpcmspmayaPSNLGRSRaggg 156 
Q17135   55 GMGTGYPAAG-------GMGGLQSYPAgSVNAmGtMQT------------------------------MNNMALNRnaia 97   Florida lancelet
Q1PA44   76 GMNPGMGSMGhm----nSMGSMNTMG--SINGmNsMGAmnnpaams--------------mryaqaqaANSIDRIR---- 131  purple sea urchin
Q2WBY1   80 TMGAGMGAAMgmgsmmgSMNSMSPMT--SMNGmAaMGNmtssmsmngmqg---------pvspmsmnsmaaMNRARp--- 145  Dumeril's clam worm
Q8I6T9   76 SMHGSMTAMNpm----nTMGSMNSMG--AMGSmNgMSSigsmssmngmnrq-------mdpnmmsmdraqaLNRAR---- 138  common limpet
Q9UAH4   50 AMNHNMGSMNsm----nTMGSMNTM---NMNTmGsMNAmagspamnme----------laranslanqMNAVNRARt--- 109  Ptychodera flava
O16108   66 SHPTHHS-----------------------QMsVgGSAaypginqgvgl--------------spnmalsmcinRR---- 104  Molgula oculata
Q6DL96   73 GHSPHSVQIAaa-----------------aAAaVgSPPmgtayagmatgv-------------gitpnmalmlnRR---- 118  vase tunicate
Q9GV73   73 SHPSHS------------------------QMaVgVGGmspypsmnpgvgl-----------apnlpimsmginRR---- 113  Halocynthia roretzi
Q93133   56 GMNGVGMGTIppshtsmTTMGMNSVPGsQLTTmStMGAqhpglanslgvgmahpgqsmspmsmqgsvnGVNMNLTRedvl 135  Florida lancelet
5A5U_B  157 gDAKTFKRSYPHA 169 
Q17135   98 eREKAYRRSYTHA 110  Florida lancelet
Q1PA44  132 -ADKTYRRSYTHA 143  purple sea urchin
Q2WBY1  146 -DAKNYRRSYTHA 157  Dumeril's clam worm
Q8I6T9  139 --DKNYRRSYTHA 149  common limpet
Q9UAH4  110 -DNKTYRRSYTHA 121  Ptychodera flava
O16108  105 -TEKTYRRNYTHA 116  Molgula oculata
Q6DL96  119 -TEKQYRRNYTHA 130  vase tunicate
Q9GV73  114 -TEKTYRRNYTHA 125  Halocynthia roretzi
Q93133  136 nRQKQYRRSYTHA 148  Florida lancelet
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