Conserved Protein Domain Family
PLU-1

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pfam08429: PLU-1 (This model is not part of the current CDD release)
PLU-1-like protein
Sequences in this family bear similarity to the central region of PLU-1. This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer. This region is found in various other Jumonji/ARID domain-containing proteins (see pfam02373, pfam01388).
Statistics
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PSSM-Id: 518256
Aligned: 89 rows
Threshold Bit Score: 136.558
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007810393   931 LWEEKYAKMLD--EETSPsLKSLRALLHEGERVPF--DIPSL-PILKEFVDRCNDWVEEATNYI---------VRKQQNR 996 
21_pfamImport    1 TWLARVEEALSgnRKPKItLCELTELLIEANDKEF--PRNDIiSILHYQVSKCIEVSALARTIL------------SNAR 66  
XP_002111443   729 AWSNKTTKYLTdqSGNKPgIDDLRELLAIAEKCNF--TQCDLvKTLKYCIARAERCQKAALQYV---------GKKHRTS 797 
XP_009017068    46 SWIIKAKIAMEakGRDRLaLSSMQCILKEARENNF--PSCPTlEALKRECEFGERCQTVACMLLgpdgnivsrRKVKRRR 123 
6_pfamImport     1 GWKEESEEMLE--TKGKPgLERIEQFIDEAKQNKY--PQTDQvSKLMGIRQTAKGAIEKANQLL---------FKKVRTR 67  
Q61T02         777 GWQEDDDDMYT--QEEMPkLEPMVDLYNVEEQSSS--RQKNQvHNIIAIQHTAKSAIEKANQLL---------FKKVRTR 843  Caenorhabdit...
EFO93880       759 GWKEESEEMLE--KTGKPeLESIEECIDVAKQNKY--PQTDQvHKLTTISHTVKTAIEKTSQLL---------HKKVRTR 825 
9_pfamImport     1 GWKEESDEMLE--EEGKPkLERIEEFIDAAKHNKY--PQTDQvHKLITIRHTAKSAIEKANQLL---------FKKVRTR 67  
Q23541         774 GWKEESDEMLE--EEGKPkLERIEEFIDSAKQNKY--PQTDQvHKLITIRHTAKSAIEKANQLL---------FKKVRTR 840  Caenorhabdit...
Q4UIF2         261 YWNNLVADSLSrtGSSRLtLSEARVFINDYRYItfgllNSELsNRLENEIKIAEHYSNKVRQKL---------SSI---- 327  Theileria an...
XP_007810393   997 RKNEkawqsg---------mrksngNAYQDQKERESRNVSNIYRLLREAEHIGFDCPEI-GQLQERATAIKEFQLNAART 1066
21_pfamImport   67 KRNE-----------------------------TRRITVEELAMFAREMDNLPCALMET-PAIKQLLNRAKHIQRIANKN 116 
XP_002111443   798 QPSI-----------------------GRK------LSIDEMRGLLDQVETLPCEINEV-AVVQDLASRVQILRSEAQKV 847 
XP_009017068   124 SKRKkgvaaddyddyddeeedvvagEVDSKLEDKEKVSYEEFMTIVNRMDRLSFKLMCA-PKLKELSIRIEKFRKKLQTD 202 
6_pfamImport    68 TKTR-------------------------CQRADTRTDAEGVRALIEQMQAMDCNLAFIiDKLERWMENVDSWRIKAREA 122 
Q61T02         844 TKTR-------------------------CQRADTRTDADGVKSLIEQMQGMDCNLSGLiDKLQKFLDQIDAWRSKAQIM 898  Caenorhabdit...
EFO93880       826 TKTR-------------------------CQRADTRMDIVDVKLLIEQMVSMDCNLSSYtGQLEQLLQRIDAWRKKAEEV 880 
9_pfamImport    68 TKTR-------------------------CQRADTRTDAEGVRSLIEQMQAMDCNLTSIiEKLEKWMEEIEQWRAKCRVM 122 
Q23541         841 TKTR-------------------------CQRADTRTDTEGVRSLIEQMQAMDCNLTVIiDKLEKWMEQVEMWRNRAKDA 895  Caenorhabdit...
Q4UIF2         328 --------------------------FDKESEESCSIDLSVAENLLKEGSLLTFSTPEF-ISLSHLFYSVASLRNLLDES 380  Theileria an...
XP_007810393  1067 LEN-TATVSMETIEELLEEGRSFNVDTPEVDRLSRVLEQMRWNQKars----------------srgLF------LSLKD 1123
21_pfamImport  117 LTF--RNVKTSKISVCVSWMKSINLEFKELPILQERLREKEWLDKsnails-------------------kndsvVDFVL 175 
XP_002111443   848 LNElKPD--IGKLIQLLDAGASLDVDLPEIPKLQDKLRQAEWINEvrail--------------------sdvrpTSLDA 905 
XP_009017068   203 IQKhPLD--NELIDSYFDQCYEYPVEVPELAMLHQCLSLISWLEEvsci--------------qnetIQ------LSCET 260 
6_pfamImport   123 ISH-ESAHSKESFDKLIEEGDEFDIKMVEIDELKKVIQMKEWVVRaqevtswtvtadmekdpeyeykTR------WTCSD 195 
Q61T02         899 MSQ-EHKYSKDDFEHFIEEGDEYDIKLSEIEELRKVVGMKEWSERaieitswaptsnmekdidfeykMR------YTNKD 971  Caenorhabdit...
EFO93880       881 MDR-EQEYTKEDLERVVEEGEEFDIKLTEIEELRKLVEMKEWSERarkvtswtptsnmenefdfeckKR------LIREN 953 
9_pfamImport   123 ISH-QEKYTIEDFEKTVDEGDEYDIKLTEIEDLKKVIASKEWSQQagfvtswsatadmekaidfdykVR------YSSKD 195 
Q23541         896 IYR-EQEYSKEEIEKIIEEGDEYDIKLEEIDELRKVIQMKDWSDRarkvttwkatpdmekdidfeykLR------YASSD 968  Caenorhabdit...
Q4UIF2         381 ILR----SDITNSNTLIEECDNSVIKIPDLENVKLHLSKIMWLNN----------------------AQkyshksVNYKL 434  Theileria an...
XP_007810393  1124 VTELIEDGKRLEV-PS--Y-NDHLKFYSDQKLAGETWEAKAKEL------------------------------------ 1163
21_pfamImport  176 LDGLIKESESLPLsQPfgKkKKALIKMKESVAASQLNKNKEKIIe----------------------------------- 220 
XP_002111443   906 LRSLIDSGQKVTLkFC--SvENSLNELHGLLSQSERWEERAKQC------------------------------------ 947 
XP_009017068   261 VLRLRETGLSFATsDP--KiESSLEFLEELITTFKKLEFKASTY------------------------------------ 302 
6_pfamImport   196 ILSLIRDGSRTPTeTT----SQLTAKLQIMLREANIRESEATEF------------------------------------ 235 
Q61T02         972 VIALIREGSRSSSnHT----SQLIAKLQHMLAEANKREAEATEY------------------------------------ 1011 Caenorhabdit...
EFO93880       954 ILSLIQEGGRNPSrQV----NDLLLKLQQMLSQASAREEEAQEF------------------------------------ 993 
9_pfamImport   196 VLALIKDGSRNTSsQA----INIVAKLQQMLSEANEREAEAHDF------------------------------------ 235 
Q23541         969 ILSLIRDSPRNPTdGT----SKLVFELQQMLRDANTLEVIANNF------------------------------------ 1008 Caenorhabdit...
Q4UIF2         435 VVELID------NtPEelKsHTLYQNLKNKVDMAFKLIEKLKEPkfkyltstdelrinnqnkdkniekivdkdkiidkek 508  Theileria an...
XP_007810393  1164 -----------------------Ih--AAVVHYPQLEALSNQVQa----------------------------------- 1183
21_pfamImport  221 -----------------------LdveREHDTINLLPNIPSEAV------------------------------------ 241 
XP_002111443   948 -----------------------Ll-aNPPYGISALEAIASQAS------------------------------------ 967 
XP_009017068   303 -----------------------Tf-nKPWQSVEDVERLVIECQ------------------------------------ 322 
6_pfamImport   236 ---------------------------MKKPSLDTLQDTWNNVRksdwfsdsnidtl----------------rteivmv 272 
Q61T02        1012 ---------------------------FDNPSLDKLQSIWKNLRtsdwfyepyinlv----------------rfeigqi 1048 Caenorhabdit...
EFO93880       994 ---------------------------FKNPSLSLLQTVWNSLRnsdwlseqylnsv----------------rfevaqv 1030
9_pfamImport   236 ---------------------------LQNPTLSKLELVWQKLRqsdwfseqcefetitliqtviwfsdinavrseiihm 288 
Q23541        1009 ---------------------------CENPALDQLQSIWQSLRetdwfyekyinmv----------------ryeiihv 1045 Caenorhabdit...
Q4UIF2         509 imekdsdsedetsdeeeisvengIe-mNKKLKPEELEDIHNNYQ------------------------------------ 551  Theileria an...
XP_007810393  1184 ----nALPVSQETLAEVDRILHKQREAH---RQIMDITERCrnsDFRKR-------------------PKYAEVVDIIRN 1237
21_pfamImport  242 ------------------SNLEMAKSLQ---EKILAVLKGE---VV----------------------LTTNVLAEILSR 275 
XP_002111443   968 -----CVRTYLPHVASLRDAIQKAKEWN---NKIESI-QA------DKYy------------------PYLAVIEDIASK 1014
XP_009017068   323 -----ESKMVIPSIGLLSSALKDAKEWC---SAAEEITKN------APVtrrrsmlmlsgsndesvvkPKLEDLDNLISK 388 
6_pfamImport   273 mkiktLIDAAIPSLSKLD--------LH---SQLLQLTES-----E----------------------ITLANILEILRT 314 
Q61T02        1049 akiksMIDSTIPALSGLD--------LK---PQLLRLGDS-----S----------------------ITFAKAVELSKA 1090 Caenorhabdit...
EFO93880      1031 akiksMIDFAVPSLSGFE--------VK---DQLQRLPES-----E----------------------IILSQAIDINKN 1072
9_pfamImport   289 ariksMIDFAIPNLSGFD--------LK---SQLQRLAES-----Q----------------------ITLSKAVEISKA 330 
Q23541        1046 akiksMIDAAIPVLSEFD--------LK---TQLQKIVNV-----E----------------------ITLSKAAEISKA 1087 Caenorhabdit...
Q4UIF2         552 -----EINLIIPSFKNIEPAYFMWKRFQrrlRKVEALISSEn--SA----------------------NCTIECLVLLQQ 602  Theileria an...
XP_007810393  1238 V-DE-LNSKPTGTIDLENERKRHEDWMRRGKKLFGKSNAPLHILK 1280
21_pfamImport  276 S-QA-FPFKVSGIAEFEENIKKVQSWKSLASRFFLKRRSPYTLLQ 318 
XP_002111443  1015 G-RV-IPVKLDFLPQLESQITAAKTWKDRAARLFLRKNSSYTLLE 1057
XP_009017068   389 S-QQ-IPISLPQLENIINIKSQVTGWIAQLSHMLL-KSSQQSLLK 430 
6_pfamImport   315 CeQSiCLNGSTSHLALNEAADKIKSFTERMSKLFKPINAYHNLFE 359 
Q61T02        1091 CeLSkTLHKSQEHSSLLELINRMNLFTERIAKLFKPMNSYHNLFE 1135 Caenorhabditis briggsae
EFO93880      1073 CeISkTLRHSREHSPLCDMVNKMLSFTERLTKLFKPINAYHNLYE 1117
9_pfamImport   331 CeLSkCLKDSQDTLGLQEMINRMNNFTERIAKLFKPKNAYHNVFE 375 
Q23541        1088 FeTSkCLNGSEEHLGILDMISTMNAFTQRIAILFKPNNAYHNLFE 1132 Caenorhabditis elegans
Q4UIF2         603 A-ET-LKEYIDIDNVLEPINSDVENSLK-----FEKKCRNLlnrf 640  Theileria annulata
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