Conserved Protein Domain Family
PLU-1

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pfam08429: PLU-1 
PLU-1-like protein
Sequences in this family bear similarity to the central region of PLU-1. This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer. This region is found in various other Jumonji/ARID domain-containing proteins (see pfam02373, pfam01388).
Statistics
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PSSM-Id: 400641
View PSSM: pfam08429
Aligned: 97 rows
Threshold Bit Score: 127.709
Threshold Setting Gi: 74953814
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015781652  465 KWKTEV-NSLLYnwSEQVP-ITVLRNLYDIAEDKIYPqdcpeyekLCNAlQEFEQVHKIVQELLEQQNKFIEEENSKRVK 542  two-spotted s...
XP_006682412  939 SWRNRLkSMLLE--ATSPPpLKSFVKLLKEAQHMPEV--------QAEV-ATLTQFIDQANAWVNSVKQVVHKPKRHSVK 1007 Batrachochytr...
XP_002111443  729 aWSNKT-TKYLTdqSGNKPgIDDLRELLAIAEKCNFT--------QCDLvKTLKYCIARAERCQKAALQYVGKKHRTSQP 799  Trichoplax ad...
5_pfamImport    1 TWLARV-EEALSgnRKPKItLCELTELLIEANDKEFP--------RNDIiSILHYQVSKCIEVSALARTIL---SNARKR 68  
3_pfamImport    1 GWKEES-EEMLE--TKGKPgLERIEQFIDEAKQNKYP--------QTDQvSKLMGIRQTAKGAIEKANQLLFKKVRTRTK 69  
EFO93880      759 GWKEES-EEMLE--KTGKPeLESIEECIDVAKQNKYP--------QTDQvHKLTTISHTVKTAIEKTSQLLHKKVRTRTK 827  Caenorhabditi...
EGT46596      801 GWKEES-DEMLE--EEGKPkLERIEEFIDAAKHNKYP--------QTDQvHKLITIRHTAKSAIEKANQLLFKKVRTRTK 869  Caenorhabditi...
Q23541        774 GWKEES-DEMLE--EEGKPkLERIEEFIDSAKQNKYP--------QTDQvHKLITIRHTAKSAIEKANQLLFKKVRTRTK 842  Caenorhabditi...
EDO07170      197 EWHDTS-RRLIS----EQIpIEEARTILEDFKEItgg------liKVDLvTEIEDEIKSCEAFGAKVLNLI--------- 256  Babesia bovis
Q4UIF2        261 YWNNLV-ADSLSrtGSSRLtLSEARVFINDYRYItfg------llNSELsNRLENEIKIAEHYSNKVRQKLSSI------ 327  Theileria ann...
XP_015781652  543 YQsslaqssarikkkmesekdenkngnnpvksklvlsrNNESDNENRKLSVFEFSGFCEVLDTYPFKVPGS-DELRKLLF 621  two-spotted s...
XP_006682412 1008 SNf-----------------------------------LLQHTTKSDRPTLSHIKCLFESSKTLAFDSAEL-KLLQILYI 1051 Batrachochytr...
XP_002111443  800 SI-------------------------------------GRK------LSIDEMRGLLDQVETLPCEINEV-AVVQDLAS 835  Trichoplax ad...
5_pfamImport   69 NE-------------------------------------------TRRITVEELAMFAREMDNLPCALMET-PAIKQLLN 104 
3_pfamImport   70 TR---------------------------------------CQRADTRTDAEGVRALIEQMQAMDCNLAFIiDKLERWME 110 
EFO93880      828 TR---------------------------------------CQRADTRMDIVDVKLLIEQMVSMDCNLSSYtGQLEQLLQ 868  Caenorhabditi...
EGT46596      870 TR---------------------------------------CQRADTRTDAEGVRSLIEQMQAMDCNLTSIiEKLEKWME 910  Caenorhabditi...
Q23541        843 TR---------------------------------------CQRADTRTDTEGVRSLIEQMQAMDCNLTVIiDKLEKWME 883  Caenorhabditi...
EDO07170      257 --------------------------------------TTPSTGSVRTVSLEDVHSMLQESRSCKFLVPEV-VGLEAIFR 297  Babesia bovis
Q4UIF2        328 --------------------------------------FDKESEESCSIDLSVAENLLKEGSLLTFSTPEF-ISLSHLFY 368  Theileria ann...
XP_015781652  622 RCVEIDKLIDSYLDEntSLKIDSRKLLNLIQDANTISFICFErkLDILKEKLIQIKWLEDcdpf---------------l 686  two-spotted s...
XP_006682412 1052 KVTEYCNMAQKVLDE--LPNVSDDTLEATYNSGQATGVATLQ--QSAIHLVMKQRSWQTRcsct--------------ih 1113 Batrachochytr...
XP_002111443  836 RVQILRSEAQKVLNEl-KPD--IGKLIQLLDAGASLDVDLPE--IPKLQDKLRQAEWINEvrail--------------- 895  Trichoplax ad...
5_pfamImport  105 RAKHIQRIANKNLTF---RNVKTSKISVCVSWMKSINLEFKE--LPILQERLREKEWLDKsnails-------------- 165 
3_pfamImport  111 NVDSWRIKAREAISH--ESAHSKESFDKLIEEGDEFDIKMVE--IDELKKVIQMKEWVVRaqevtswtvtadmekdpeye 186 
EFO93880      869 RIDAWRKKAEEVMDR--EQEYTKEDLERVVEEGEEFDIKLTE--IEELRKLVEMKEWSERarkvtswtptsnmenefdfe 944  Caenorhabditi...
EGT46596      911 EIEQWRAKCRVMISH--QEKYTIEDFEKTVDEGDEYDIKLTE--IEDLKKVIASKEWSQQagfvtswsatadmekaidfd 986  Caenorhabditi...
Q23541        884 QVEMWRNRAKDAIYR--EQEYSKEEIEKIIEEGDEYDIKLEE--IDELRKVIQMKDWSDRarkvttwkatpdmekdidfe 959  Caenorhabditi...
EDO07170      298 NLLSLRNLMETSVLE-----LDVSECESLVSMTEKGIIRLPR--LDDLRNRLRESVWLNG-------------------- 350  Babesia bovis
Q4UIF2        369 SVASLRNLLDESILR-----SDITNSNTLIEECDNSVIKIPD--LENVKLHLSKIMWLNN-------------------- 421  Theileria ann...
XP_015781652  687 drKQnprcraSNLSDLKSLIESGMDLKApSN--VvTSYLNRLNMIWEEANHWLDKAKDI--------------------- 743  two-spotted s...
XP_006682412 1114 ssKG------VTLENVQKLFKEGIDLSIpPT----DSILSMCRDQIKTGEAWVVRATQL--------------------- 1162 Batrachochytr...
XP_002111443  896 -----sdvrpTSLDALRSLIDSGQKVTLkFC--SvENSLNELHGLLSQSERWEERAKQC--------------------- 947  Trichoplax ad...
5_pfamImport  166 -----kndsvVDFVLLDGLIKESESLPLsQPfgKkKKALIKMKESVAASQLNKNKEKIIe-------------------- 220 
3_pfamImport  187 ykTR------WTCSDILSLIRDGSRTPTeTT----SQLTAKLQIMLREANIRESEATEF--------------------- 235 
EFO93880      945 ckKR------LIRENILSLIQEGGRNPSrQV----NDLLLKLQQMLSQASAREEEAQEF--------------------- 993  Caenorhabditi...
EGT46596      987 ykVR------YSSKDVLALIKDGSRNTSsQA----INIVAKLQQMLSEANEREAEAHDF--------------------- 1035 Caenorhabditi...
Q23541        960 ykLR------YASSDILSLIRDSPRNPTdGT----SKLVFELQQMLRDANTLEVIANNF--------------------- 1008 Caenorhabditi...
EDO07170      351 --ANrlsqrpVRFSFAKSLLA------TvPDvlRnHPLYAFVQKKCANAEKWIQRVSRYsfyrmvmndnpsgng------ 416  Babesia bovis
Q4UIF2        422 --AQkyshksVNYKLVVELID------NtPEelKsHTLYQNLKNKVDMAFKLIEKLKEPkfkyltstdelrinnqnkdkn 493  Theileria ann...
XP_015781652  744 --------------------------------------LnavkqnsstlnREKLDLDAMAELMDQSA------------- 772  two-spotted s...
XP_006682412 1163 --------------------------------------Ln----------DKTITLDILDQFLLDSKn------------ 1182 Batrachochytr...
XP_002111443  948 --------------------------------------Ll---------aNPPYGISALEAIASQAS------------- 967  Trichoplax ad...
5_pfamImport  221 --------------------------------------Ldv--------eREHDTINLLPNIPSEAV------------- 241 
3_pfamImport  236 --------------------------------------------------MKKPSLDTLQDTWNNVRksdwfsdsnidtl 265 
EFO93880      994 --------------------------------------------------FKNPSLSLLQTVWNSLRnsdwlseqylnsv 1023 Caenorhabditi...
EGT46596     1036 --------------------------------------------------LQNPTLSKLELVWQKLRqsdwfseqcefet 1065 Caenorhabditi...
Q23541       1009 --------------------------------------------------CENPALDQLQSIWQSLRetdwfyekyinmv 1038 Caenorhabditi...
EDO07170      417 ------------------------akkdsstaqdsdmdVd---------tGIRCDASTFEELCTSYH------------- 450  Babesia bovis
Q4UIF2        494 iekivdkdkiidkekimekdsdsedetsdeeeisvengIe---------mNKKLKPEELEDIHNNYQ------------- 551  Theileria ann...
XP_015781652  773 ----------------------------ESPGLRavdlnPVWDELQQLYSLCQQWS----NTALEMMTKLrsdkqKDEEN 820  two-spotted s...
XP_006682412 1183 ---------------------------eRFSSTV-------YDKLQSVSESAHAWVsraqPYIDAIQQK--------RNS 1220 Batrachochytr...
XP_002111443  968 ----------------------------CVRTYL-----PHVASLRDAIQKAKEWN----NKIESI-QA--------DKY 1001 Trichoplax ad...
5_pfamImport  242 ----------------------------------------------SNLEMAKSLQ----EKILAVLKGE-----VV--- 263 
3_pfamImport  266 ----------------rteivmvmkiktLIDAAI-----PSLSKLD--------LH----SQLLQLTES-------E--- 302 
EFO93880     1024 ----------------rfevaqvakiksMIDFAV-----PSLSGFE--------VK----DQLQRLPES-------E--- 1060 Caenorhabditi...
EGT46596     1066 itliqtviwfsdinavrseiihmariksMIDFAI-----PNLSGFD--------LK----SQLQRLAES-------Q--- 1118 Caenorhabditi...
Q23541       1039 ----------------ryeiihvakiksMIDAAI-----PVLSEFD--------LK----TQLQKIVNV-------E--- 1075 Caenorhabditi...
EDO07170      451 ----------------------------KLGVTL-----PLFRNIEPIYQSLRRLQrr-lAKIESLLKANs---rNP--- 490  Babesia bovis
Q4UIF2        552 ----------------------------EINLII-----PSFKNIEPAYFMWKRFQrr-lRKVEALISSEn----SA--- 590  Theileria ann...
XP_015781652  821 i-------PYASELEDLYNKG-KN-IGIHFDVLGVMKASLQVANDWKDKVNKTFLRRNSFYPI 874  two-spotted spider mite
XP_006682412 1221 htsvpthqANMDELQALVADG-NL-QSFPPPHFSLVTEAVAQANQWTIRARRAFVGKshqitd 1281 Batrachochytrium dendrobatidis...
XP_002111443 1002 y-------PYLAVIEDIASKG-RV-IPVKLDFLPQLESQITAAKTWKDRAARLFLRKNSSYTL 1055 Trichoplax adhaerens
5_pfamImport  264 --------LTTNVLAEILSRS-QA-FPFKVSGIAEFEENIKKVQSWKSLASRFFLKRRSPYTL 316 
3_pfamImport  303 --------ITLANILEILRTCeQSiCLNGSTSHLALNEAADKIKSFTERMSKLFKPINAYHNL 357 
EFO93880     1061 --------IILSQAIDINKNCeISkTLRHSREHSPLCDMVNKMLSFTERLTKLFKPINAYHNL 1115 Caenorhabditis remanei
EGT46596     1119 --------ITLSKAVEISKACeLSkCLKDSQDTLGLQEMINRMNNFTERIAKLFKPKNAYHNV 1173 Caenorhabditis brenneri
Q23541       1076 --------ITLSKAAEISKAFeTSkCLNGSEEHLGILDMISTMNAFTQRIAILFKPNNAYHNL 1130 Caenorhabditis elegans
EDO07170      491 --------NVANDCIFLLQHS-EP-LAAYIDISEQLQPLRTDVEQWLS-----YEKRCRKILD 538  Babesia bovis
Q4UIF2        591 --------NCTIECLVLLQQA-ET-LKEYIDIDNVLEPINSDVENSLK-----FEKKCRNLln 638  Theileria annulata
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