Conserved Protein Domain Family
ICE2

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pfam08426: ICE2 (This model is not part of the current CDD release)
ICE2
ICE2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER. It has also bee identified as a protein which is necessary for nuclear inner membrane targeting.
Statistics
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PSSM-Id: 518253
Aligned: 55 rows
Threshold Bit Score: 321.471
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003684930  61 AVLVAFYLLNIVVTIPISFKIGGIYCGLSFTGTLFGLYFISTSVTIITKRLthnTTLrLLASSLFYIQNFIISSLLQIYL 140
XP_002492005  15 VLLATLYLVLIVLTTPLSFEIGGLECGLSYSISILLLYFVLATIRVLKCNR-------ILSSFLYYLQHLLLPSLLFTFL 87 
EEQ36336       6 pLLSAYYLALVVLTIPLAFDVGGIECGLAYSLAMSALYFVLTTLRLASRRS---PLA-RVATVFYYSQHVLMPSLLMHFL 81 
CCE88595      14 AVLSVLYLTLIVLSIPLAFDVGGVQCGLAFSLTVLLLYSILTTIRLIFRRR---KYF-RWISIVYYCQHIFIPSLLTLFL 89 
XP_001486301  12 ALFSFAYLALVILTVPLAFDVGGIPCGLSYSFTLFSIYFVLTTVRMITKKS---RWF-RWVSLLYYTQHFVIPSLLTFFL 87 
XP_001385893  14 AFLGTLYLVLVILTIPLAFDVGGVTCGLAFSLTTFLLYFSLMTIRLVTRRS---KYF-RWISILYYSQHFVIPSLLTFFL 89 
XP_002545902  13 GIFSTVYLGLIILTIPLAFDVGGVYCGLAFSLTTLVTYFILTTIRIAVRRT---RYF-QWISIIYYCQHFFIPSLLTYFL 88 
EDK45245      17 ALFASLYLALIILTIPLAFDVGGVTCGLAFSFTTLVIYFVLTTIRILSRRT---KYF-KWISIVYYSQHFFIPSLLTYFL 92 
XP_036665835  14 ALFASLYLVWVILTIPLAFDVGGVNCGLAFSLTLLVTYFILTTIQLLARRT---RYF-KWISLVYYGQHFLIPSLLTYFL 89 
Q6BYC3        14 AVLSTVYLALIILSIPLAFDVGGITCGLAFSFTTFTLYFVLTTIRIVTRKS---RYF-GWVSLLYYLQHIIIPSLLTLFL 89  Debaryomyces ha...
XP_003684930 141 RGFNNKdlitaLtflddyyyNek-----ngTNTKYQilfiikdyfvnimnlilfrednglnkmlqlalksegnsvpdpqk 215
XP_002492005  88 SYFkenhr-----------------------------------------------------------------------l 96 
EEQ36336      82 QRYPRSgalppAla------------------------------------------------------------------ 95 
CCE88595      90 SYY-----------------SskhtsdsmaSRPIEM-------------------------------------------- 108
XP_001486301  88 SYYstkq-------------------psprLNPVDV-------------------------------------------- 104
XP_001385893  90 SYY-----------------RtenkvvykyINPVDI-------------------------------------------- 108
XP_002545902  89 SYY-----------------SngvtpneskYNPIMI-------------------------------------------- 107
EDK45245      93 SYYrqnhq------------------iesgWSLLSV-------------------------------------------- 110
XP_036665835  90 SYYsndpk------------------ieskLNPVLI-------------------------------------------- 107
Q6BYC3        90 SYY-----------------RtnqpttltaYHPHEI-------------------------------------------- 108 Debaryomyces ha...
XP_003684930 216 lnswILFFYYYYIFIKPWKFLLINSTPFFTLLEGFFTILGIQTIGETNIWLKQQKhSSFWVILSLLSSGGVITATLYYLN 295
XP_002492005  97 ltndILQNIWWNYIISSWKFFLVNSTPLFIILEGFCSLLLIQAVGQISTWLVRNK-SDTLSILNLMLSSIIISSSLYFVL 175
EEQ36336      96 ----------------vWRYLLVHSTSVFTVAEGFCSLLLIQAASQTLGWLTAHR-SDSWLFVSLIGSGCTITGALYFLY 158
CCE88595     109 -----------------WRFIMLHSTPIFTILEGFCSLLLIQAIGQTVEWLTTHK-SDSWLIVSLIGSGSTITAALYFLY 170
XP_001486301 105 -----------------WKFCVVNSTPIITIMEGFCSLLLIQAVGQTLNWFTIHR-SDNWLIVSLVGSGLTTTTACYFLY 166
XP_001385893 109 -----------------WRFLLINATPVFTILEGFCSLLLIQAIGQTINWLTIYK-SDTWLIISLVGSGSTITAAFYFLY 170
XP_002545902 108 -----------------WKLILINSTPLFTILEGFCSLLLIQAVGQTVNWLTLYK-SDSWLILSLIGSGSVITASFYFLY 169
EDK45245     111 -----------------WKTLLVNATPVFTILEGFCSLLLIQAIGQTVNWLTNYK-SDSWLIISLVSSALVDTAAFYFLY 172
XP_036665835 108 -----------------WKFLLINATPIITILEGFCSLLLIQAIGQTVNWLTMYK-SDSWLIISLIGSAVVDTGAFYCLY 169
Q6BYC3       109 -----------------WRYFIVNSTPIFTILEGFCSLLLIQAIGETVNWLTVYK-SDSWLIVSLMASGSTITAALYFLY 170 Debaryomyces ha...
XP_003684930 296 RIYVTPfwDLTVSTASMLGFTLSIVGGLGVFGIVSKNGSAIESSLFFAYIVRCIYEMSPELAISATDef-lEGFNEVWQM 374
XP_002492005 176 RIYVST--TIGSLSASLLGSILTLTTILSIYGIMKNKASPLESSLLISYIVKCIYDLFPELSQHNINnlikFIMKEFTRI 253
EEQ36336     159 RIYIFPl-ALDLGNASLLGSFLTVTAGLGLYGIVSGKGSMIESSLLFAYIVRCIYETFPSLSEDATQav-aHVFAQTTAN 236
CCE88595     171 RIYVFPf-TIDLLSASLLGSSLTLTAGIGLFGIVSGKGSIIESSLLFAYIVRCIYETFPILSQDASKal-aSLFTQTTYN 248
XP_001486301 167 RIYTLNf-TIDMVNASLLGSSLTLTIGIGAFGIVSGRGSMIESSLLLAYIVRCIYETFPDLSENASEal-aSLFAQTTTT 244
XP_001385893 171 RIYVFPf-TIDIVSASLLGSLLTLTVGIGGYGIVSGKGSMIESSLLFAYVVRCIYETFPILSEGATRtl-tSLFTQATNN 248
XP_002545902 170 RIYVLPf-AIDMFSASLLGSLLTTTLGLGLFGIVSGKGSMIESSLLFAYIVKCIYETFPILSEGASQal-tNLFNLTTQN 247
EDK45245     173 RIYVFPf-TIDILSASLLGSLLTLTIGLGLFGIVSGKGSMIESSLLFAYIVRCIYETFPILSEDASKal-aHLLMLTTQN 250
XP_036665835 170 RIYVLPi-TIDILESSHLGSLLTLTFGLCLYGIVSGKGSMIESSLLFAYIVRCIYETFPSLAEGASQal-aNLLTSASQN 247
Q6BYC3       171 RIYVFPf-TIDMISASLLGSLLTLTAGLGLFGIVSGKGSMIESALLFAYIVRCIYETFPILSEDASKtl-tSIFTQTTFN 248 Debaryomyces ha...
XP_003684930 375 NQNRITVadnvltyckkyimdafssfssiehhlfpktielgISKNLIvkQFWVFLKNFTInVPSSINDLIQItAQMAVDS 454
XP_002492005 254 NEHSMMInknfitslsnayhnyny---------sydltkleqyykivkyFSNKTFEFLTEsFPQSFESIWEF-LKLSSSN 323
EEQ36336     237 LRLELAH----------------------------------LPRPVAd-TLSAFLPSLAAnLPHSFKAVWDV-FFSAVHK 280
CCE88595     249 LKNEIPK----------------------------------LPPQITn-TVMSLFPFLAEnLPGSFKTIWEF-LITAILK 292
XP_001486301 245 LKNQIPL----------------------------------LPPTIId-TVLNAVPFLASnLPMTMKTIWHF-LVISLQK 288
XP_001385893 249 LRNEIPK----------------------------------LPHQIIn-PISQLIPFLASnLPGSFKTIWEF-LLMAIQK 292
XP_002545902 248 LKKEIPK----------------------------------IPPSILn-PISEVVPFLAStLPSSFKGVWKF-LIMAIQT 291
EDK45245     251 VRKEIPK----------------------------------IAPSILn-PISELVPFLTStMPSSFKGVWEF-LVMAIQN 294
XP_036665835 248 VRNEIPK----------------------------------IPPSIMn-PISELVPFLTKtFPSSLKGVWEY-LVEALQK 291
Q6BYC3       249 LRNEIPK----------------------------------LPPQITn-TVLQLLPFLASnLPGSFKAIWEF-LIMSIHK 292 Debaryomyces ha...
XP_003684930 455 ISPAIIINLSFRLMIFYSATRIIPAIQRRTKP------D----------------------------------------- 487
XP_002492005 324 LTLPIILSLAYRIGVFFAATKIIPILQPNNRNfk---------------------------------------------- 357
EEQ36336     281 LTLPLLVNLAYRIGVFYAATKIIPSLYHTLPHs----pArtpqtsssslaslgrddkqsendkqndsend-------nqn 349
CCE88595     293 LPLPLVLNLAYRIGVFYAATKIIPSIYHGAPYls--tpPrtpshirsrqsssshlsgdvnyfplanaski--------ek 362
XP_001486301 289 LTIPLLLSLAYRLSVFYAATKIIPSLYYGSMYptf-spPrtpasksrqssssslf------------------------- 342
XP_001385893 293 LTLPLLLNLAYRIGVFYAATKIIPLLYQNAAYpn--tpPrtppqatrsrqasnkslselassipttedt---------nl 361
XP_002545902 292 LTLPLLLNLAYRIGVFYAATKIIPSLYQSISYpsv-tpPktpqtssrqpssvslshltdpkspts--------------- 355
EDK45245     295 LTLPLLLNLAYRIGVFYAATKIIPSLYKS-SYpnitspPkspkigsrhssstalrelanvdpsrpesattits--knsks 371
XP_036665835 292 LPLSLLLNLAYRIGVFYAATKIIPSLYKSVSYpsttslQqrsrqpsstrlssless------------------------ 347
Q6BYC3       293 LPLPLLLNLAYRIGVFYAATKIIPSLYHDASYpfn-tpPrtpsqnrsprpsstnipglsqsvsnsqtppnshhnrthets 371 Debaryomyces ha...
XP_003684930 488 ----------------------------AHDLTG------FMSAVYWFSPCMLIAMYTHLILQFSGELKKNiclwncenw 533
XP_002492005 358 --------------------------------------nyYLKLIYLYSPCIIIAVYTNLMLQYNDELDKEndswnwvii 399
EEQ36336     350 dkqneqneqneqneqneqnengsrrtrgHRPDRQmvrrpaVIRLLYAYSPCIVIAVYTHLMLSYRGELGSElmlwgwwa- 428
CCE88595     363 edtnddmpsemqlkqeslvinnakasrrREPPST------ILKLIYAYSPCIIIAVYTHLMMSYNGELGTEltiwgwwn- 435
XP_001486301 343 -------------qestiskppqkkirtRQPKAT------ILKLIYAYSPCFIIFAYTHLMMQYSGQLGTElklwgfwe- 402
XP_001385893 362 eesisfkevtkpitplrdrksfrlkpphHQPPSA------IISLIYAYSPCIVIAVYTHLMLSYSGELGTElkiwgffs- 434
XP_002545902 356 ---ssvssissskpnlrskksfrlkpphHQPPSV------IIRLIYAYAPILIIAVYTHLMLSYNGELGTElqlwpiwns 426
EDK45245     372 dltnsyntngvnripltsrksfhlkpphHQPPSA------IIRLIYAYSPCLIIAVYTHLMLSYTGELGTElqiwpiwgl 445
XP_036665835 348 -----------ervplksrksfhlkpphHQPPSA------FIRLIYAYSPCLVIAVYTHLMLSYIGELGVElqvwpiyg- 409
Q6BYC3       372 seevidtteiqplsrsqssfarnsfgkkREPRST------IIRLIYSYSPCIVIAVYTHLMMLYKGELGTElkiwgwws- 444 Debaryomyces ha...
XP_003684930 534 lssss------dvkstnlgdnsiiVDSWSFWNWCNIFWTIIIYASELIG 576
XP_002492005 400 klsnfgq--ksglfnyepvvlkddVHSWQFWNWINIFLVLSLYFIELQT 446
EEQ36336     429 ----------------daddmvivVHPWQFWNWINMGTTLLLYMAELSG 461
CCE88595     436 ----------------kdsnfhfvVHPWQFWNWVNMGTTLLLYTAELLG 468
XP_001486301 403 -----------------ssdftviVHPWQFWNWINMATTLLLYTAELLG 434
XP_001385893 435 -----------------ssavsivVHPWQFWNWVNMATTILLYAAELSG 466
XP_002545902 427 tt------------snsqdnfqiiVHPWQFWNWINMGTTLILYAAELSS 463
EDK45245     446 ssssypfssssssssssssssaivVHPWKFWNWINMGTTLILYVAELMS 494
XP_036665835 410 -----------------nagtkivVHPWKFWNWVNMATTLILYVAEL-S 440
Q6BYC3       445 ----------------pnsdiqviVHPWQFWNWVNMGTTLLLYTAELLG 477 Debaryomyces hansenii
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