2CY4,2DKQ


Conserved Protein Domain Family
PTB
?
pfam08416: PTB (This model is not part of the current CDD release)
Phosphotyrosine-binding domain
The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.
Links
?
Statistics
?
PSSM-Id: 518248
Aligned: 12 rows
Threshold Bit Score: 145.202
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2CY4_A         10 QYHVNHLVTFCLGEEDGVHTVEDasRKLAVXDSQGRVWAQEXLLRVSPSQVTLLDPVSKEEL-ESYPLDAIVRCDAVXPR 88   house mouse
Q08509         64 QYRVEHLTTFVLDRKDAMITVEDgiRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNEL-ENFPLNTISHCQAVVHA 142  house mouse
XP_005168553   51 QYHVEHLTTFVMDRKEAMLTIEDgiRKLRLLDAKGKIWTQDMLLQVDNRAVSLIDHDSKNEL-ENFPLGSIQHCQPVTNA 129 
Q8TE68         35 QYPVNHLVTFCLGEDDGVHTVEDasRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEEL-ESYPLGAIVRCDAVMPP 113  human
XP_059738305   28 QHRVEHLMTCKLGTQR-IQEPKDalQKLQEMDAQGRVWSQDLLLQVRDGWLQLLDIETKEEL-ESYRLDRIKVMDVALNT 105 
2_pfamImport    1 QYRVEHLFTFELDGRQ-LRNVSDcvEQLQLLEEMGRVWGQSMLLQVQPPRLLLTDIETKMEL-ESVAIGDVLEVKAVLDS 78  
XP_028685342 1269 ACSVLYLTSVETESLTGPQAVAR--ASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFrRHYPVNSITFSSTDPQD 1346
Q68CZ2       1310 ACNVWYLNSVEMESLTGHQAIQK--ALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFrRHYPVNSVIFCALDPQD 1387 human
Q0P4Q6         61 QYHIEHLTTFVMDRKDGVLTVDDgiRKLKLLDAKGKVWTQDMLLQVDDKGVSLYDVDTKSEL-ENFPLSSVQHCQAVMNA 139  tropical claw...
Q9VHC3        580 ATNVLWLYSCDTESLTGNEAIRK--AIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFFrKHYKADVISHCAIDPEN 657  fruit fly
2DKQ_A         20 ACSVLYLTSVETESLTGPQAVARa--sSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFrRHYPVNSITFSSTDPQD 97   human
Q5RC07         51 QYHVQHLATFIMDKSEAITSVDDaiRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEEL-ENFPLPTVQRSQTVLNQ 129  Sumatran oran...

2CY4_A         89 GRSRS--------LLLLVCQEPERAQPDV-HFFQglLLG---AELIREDIQGALQNYRSGRGER 140  house mouse
Q08509        143 CSYDS--------ILALVCKEPTQSKPDL-HLFQcdEVK---ANLISEDIESAISDSKGGKQKR 194  house mouse
XP_005168553  130 CSYDS--------ILALVCKESGQGKPDL-HLFQceDIK---ASLIHMDIESAISDHKGGKIKK 181 
Q8TE68        114 GRSRS--------LLLLVCQEPERAQPDV-HFFQglRLG---AELIREDIQGALHNYRSGRGER 165  human
XP_059738305  106 GSYNS--------VLSITVQDSDLRSTST-LLFQcqEVG---AERLKTSLEKALEEEVEQRPQL 157 
2_pfamImport   79 GPFNS--------LLTVSVQTRRRGSTSI-FVFQs-DIRvsaADLIQRDLSRAL----LNKPKT 128 
XP_028685342 1347 RRWTNpdgt-tskIFGFVAKKPGSPWENVcHLFA--ELD---PDQPAGAIVTFITKVLLGQ-RK 1403
Q68CZ2       1388 RKWIKdgp--sskVFGFVARKQGSATDNVcHLFA--EHD---PEQPASAIVNFVSKVMIGSPKK 1444 human
Q0P4Q6        140 CRYDS--------ILALVCKEPAQSKADL-HLFQcdEIK---ASLVQRDIDSAISDSKGGKQKK 191  tropical clawed frog
Q9VHC3        658 RMWTSegesdkktIFAFVARRSHSSTDNQcHVFC--DLS---VSQPAAAIVSFANRTLPTEKLR 716  fruit fly
2DKQ_A         98 RRWTNpdgt-tskIFGFVAKKPGSPWENVcHLFA--ELD---PDQPAGAIVTFITKVLLGQRKs 155  human
Q5RC07        130 LRYPS--------VLLLVCQDSEQSKPDV-HFFHcdEVE---AELVHEDIESALADCRLGKKMR 181  Sumatran orangutan
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap