Conserved Protein Domain Family
ArdcN
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pfam08401: ArdcN (This model is not part of the current CDD release)
N-terminal domain of anti-restriction factor ArdC
This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4 and the Tc-38 domain found in kinetoplastid minicircle binding proteins. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin. This domain is also found in the N-terminal region of the RP4 TraC1 primase, together with the Toprim domain (pfam:PF01751, pfam:PF13362 and pfam:PF13662).
Links
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Statistics
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PSSM-Id: 518237
Aligned: 87 rows
Threshold Bit Score: 45.7744
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCG53567        94 DDIYSYI---------------TDLIINTIEKVgHL--PWQKDWVGSGSDG---AAKNYvSKKEYTGANfLLNFDIKFDK 153
Q9RMV4          17 KEETKEI---------------MDKVLTDITK------YYNSPEDMLE------LANFMaQFSNYSPRN-MQLIKSQFPH 68  Bacillus anth...
EYT56587        41 EANLEQM---------------ESQLTRRVDEL-VTgdQWLE------------AMRFAaQFRGRSFLN-TLLIQVQHLN 91 
WP_009248012    31 KQQREEV---------------WAEVDAQAQAVfQNgdSLKG------------FLDFMaQCNTQKTPN-LLLIYGQNPE 82  Clostridia
wustl:cce_4767  15 SKAMELL---------------EEGISNLLQSG-----DWRQ------------YLQVQsQFHNYSFNN-IVLIVLQYPK 61 
WP_076004649   203 PEAKERR---------------IDEVLKKLKEG-VEgiQGSEHFRN--------FLLTMsKFHDYSIGN-LILIAAQKPD 257 Dehalogenimon...
Q4CVC0          64 RRVAKNMpmvvaqvpmstvlfnMDQLLPESEA------HWQLPIAT--------AATSVsSMRPYEGQA-QRQLEHRRMT 128 Trypanosoma c...
CDD84031         4 DKNLERF---------------AELMVEKIKEVcAS--DWTKPWFTQGTVG---VPQNL-SGRAYHSIN-RLLLYFMMDK 61 
EGJ72295         5 NQLAERF---------------AEILIRKMEEMkSE--KWEKPWFDVSGKIn-fYPQNY-TGRKYTSGN-AFLLLLACSW 64 
Q8ABW0           7 DKAAQQF---------------ANLMIEKIQQV-ED--NWQKPWITIAANTrnfFPQNL-TGRRYTGGN-AFLLLFLCEK 66  Bacteroides t...

CCG53567       154 DGkgylvpikFIQPYYLTFNQIKETGAS----------------------LKKDSKARRVI--------YYTmifsfdng 203
Q9RMV4          69 AY------------ACASFKTFKDAGFH----------------------VNKGEKAMKVFhpy--vkeFVR-------- 104 Bacillus anth...
EYT56587        92 AYsegrvptpYP-SYVAGRSDWRKLGRW----------------------PAKEQTGYLVRkpvveryaATN-------- 140
WP_009248012    83 AT------------VVKSYDYWKKEHRS----------------------PKSGVHGYTYM------------------- 109 Clostridia
wustl:cce_4767  62 AS------------RVAGYRKWQELGRQ----------------------VKKGSKAIKILaplt--------------- 92 
WP_076004649   258 AT------------RVGGFNTWKDLYRW----------------------VKKGEKGIAILap----------------- 286 Dehalogenimon...
Q4CVC0         129 CG--------FESNWWGTRLQWRKRGCHldpkavpsvlhfhkmtrlvhisMLSGGKE----------------------- 177 Trypanosoma c...
CDD84031        62 YR--------YSLPVFLTFNQAKSAGVM----------------------VTKGSTGFPVV--------YYD-------- 95 
EGJ72295        65 EG--------YRTPLFLTFNQCRELEIK----------------------IIKNEKSFPIY--------YKN-------- 98 
Q8ABW0          67 FQ--------YQTPVFMTFNQAKEAGIS----------------------VLKGSKSFPVY--------YFL-------- 100 Bacteroides t...

CCG53567       204 vlQFKTTDREKftefvksngLTKEDLRE-HLTKIPV-IKY------YNVF 245
Q9RMV4         105 --------DPKtklpipltkLTAEQKQQvKNGELKV-EKQtnyylkATAF 145 Bacillus anthracis
EYT56587       141 -----PASGRWrklgsrekpRPGETVRE-KMVNVTY----------GKVW 174
WP_009248012   110 -----------------------VSTEYeKDGEMRTgYAI------GKGF 130 Clostridia
wustl:cce_4767  93 ----------------kkieKENDNGEK-QKINALVgFRT------VNVF 119
WP_076004649   287 -cLPSKSAKMTepagaedkkKEGEEEEK-REMIRPIyFKV------VYVF 328 Dehalogenimonas formicexedens
Q4CVC0         178 -----------------------------LLKDSFVsGKTgiirqlSVSN 198 Trypanosoma cruzi
CDD84031        96 --MVVKHKDTGrrieysaykLLDEQEQA-QYKVIPF-QKT------YTVF 135
EGJ72295        99 --FLVYHRENNkriniddynLLTEEEKK-NWRLISY-LKN------YNVF 138
Q8ABW0         101 --FYVYHKETRkkitfeeykALSREQQQ-EYNVIPT-YKY------YSVF 140 Bacteroides thetaiotaomicron
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