3JBR


Conserved Protein Domain Family
VWA_N

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pfam08399: VWA_N 
VWA N-terminal
This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.
Statistics
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PSSM-Id: 400621
View PSSM: pfam08399
Aligned: 48 rows
Threshold Bit Score: 83.4822
Threshold Setting Gi: 351709376
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3JBR_F        117 EDFAsn--eVVYYNAKDDld-------pEKND--SEPG------SQRIKPVF--IDDANFRRQVSYQHAAVH----IPTD 173 
AAH90437       82 DAIKen--dIQYYDAKADsdv-----mdDDDGenLLDN------PNSLSLEF--VDDPNFKNKVNYSYTAVQ----IPTD 142  zebrafish
XP_005453547  122 DGVTen--aISYYDSKADsd-------yTEDGeeENPLe----tSSSLELEF--VDDPNFKNKVNYSSSAVQ----IPTD 182  Nile tilapia
XP_014326828  110 VDGEan--eLKYYNAKDGvnktalkekeKDKDkeEDKS------NRFIPEDF--EIDPDFKRLVSYNTTAVH----IPTD 175  southern plat...
XP_023808266  110 EKSEdn--kIFYYNAKDGtn-------kTEFEekQKGEdgdelkNRFIPDDFtnETDENFKRRVSFNTTAVH----IPTD 176  Japanese medaka
EHB12295       91 LDVVsr--nKQVVEASYT-------------------------------------------AHLTSPLTAIQdcctIPPS 125  naked mole-rat
XP_026693335  126 KEPSdeynnIQYINAPEPsniee-----------------ddyaSLRKQMQF--KSDARFERDVNKNTSIVQ----VPFN 182  vase tunicate
TDG96662       58 DNSEvd--kMVYYNAKDDl---------NQTEdgKGRK------NRYLPDDF--EIDPDFKRLVSYNTTAVH----IPTD 114  yellow perch
XP_023791299  101 DNIRee--dIEYYDSKADte-------yDDPDgeEIERe----kSNSLKLEF--TDDDNFKTKVNYSYAAVQ----IPTD 161  blue tit
XP_007234505  122 DSIKew--dIEYYDSKAEld-------yDGDEfeA---------QMSLKLEF--VYDPNFKNNVNYSYTAVQ----IPTD 177  Mexican tetra
3JBR_F        174 IYE-------------GSTIV----------LNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYP-ASPW 225 
AAH90437      143 IYK-------------GSPTI----------LNELNWTQSLERVFIENSREDPSLRWQVFGSTTGVTRYYP-ATKW 194  zebrafish
XP_005453547  183 IYK-------------GSPVI----------LNELNWTQALERVFIENRREDSSLRWQVFGSATGMTRYYP-ATPW 234  Nile tilapia
XP_014326828  176 IYE-------------GSTII----------LNELNWTDELEDVFRQNKEDDPSLLWQVFGSATGLARYYP-ASPW 227  southern platyfish
XP_023808266  177 IYE-------------GSTII----------LNELNWTDALEDVFRKNREEDPSLLWQVFGSATGLARYYP-ASPW 228  Japanese medaka
EHB12295      126 MMEpvqsrfgvlspkcGARTVpvytlavlviVCGRVPVQELRLVLADNLKSNPGIKWQYFSSEEGIFTVFP-AHKF 200  naked mole-rat
XP_026693335  183 VYS-------------KGTKL----------LKSVGWSKALNQQFKRNLELEPSLKWQYFGSTEGYIRVYP-GFQW 234  vase tunicate
TDG96662      115 IYE-------------GSTII----------LNELNWTEALEDTFRKNKEEDPSILWQVFGSATGLARYYP-ASPW 166  yellow perch
XP_023791299  162 IYK-------------GSTVI----------LNELNWTQALEDVFIENRKEDPSLLWQVFGSATGVTRYYP-ATPW 213  blue tit
XP_007234505  178 IYK-------------GaPVI----------LNELNWTQALERVFMENSREDPSLLWQAFGSATGVTRYYPaT-PW 229  Mexican tetra
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