2YKT,2D1L


Conserved Protein Domain Family
IMD
?
pfam08397: IMD (This model is not part of the current CDD release)
IRSp53/MIM homology domain
The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.
Links
?
Statistics
?
PSSM-Id: 518235
Aligned: 6 rows
Threshold Bit Score: 297.177
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2YKT_A  20 YKTIMEQFN---PSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQG-SKELGDVLFQMAEVHRQIQNQLEE 95  human
O43312  16 FQTIISDMKgsyPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGgTREIGSALTRMCMRHRSIEAKLRQ 95  human
Q9UQB8  17 YKTIMEQFN---PSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQG-SKELGDVLFQMAEVHRQIQNQLEE 92  human
Q6UXY1  16 YKSIMEQFN---PALENLVYLGNNYLRAFHALSEAAEVYFSAIQKIGERALQSPT-SQILGEILVQMSDTQRHLNSDLEV 91  human
Q765P7  15 FQAIVNDMKssyPIWEDFNSKATKLHSQLRTTVLAAVAFLDAFQKVADMATNTRGaTRDIGSALTRMCMRHRSIETKLRQ 94  human
2D1L_A  19 FQTIISDXKgsyPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADXATNTRGgTREIGSALTRXCXRHRSIEAKLRQ 98  house mouse

2YKT_A  96 MLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQG----SKNPQKYSDKELqyIDAI 171 human
O43312  96 FSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKK----GRGDIQPQLDSA--LQDV 169 human
Q9UQB8  93 MLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQG----SKNPQKYSDKELqyIDAI 168 human
Q6UXY1  92 VVQTFHGGLLQHMEKNTKLDMQFIKDSRQHYELEYRHRAANLEKCMSELWRMERKRDK-----------NVREM--KESV 158 human
Q765P7  95 FTNALLESLINPLQERIEDWKKAANQLDKDHAKEYKRARHEIKKKSSDTLKLQKKARKel-lGKGDLQPQLDSA--LQDV 171 human
2D1L_A  99 FSSALIDCLINPLQEQXEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKvdaqGRGDIQPQLDSA--LQDV 176 house mouse

2YKT_A 172 SNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKgKELLAQKLPLWQQACADPSKIP 240 human
O43312 170 NDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGE-ITHLQTISEDLKSLTMDPHKLP 237 human
Q9UQB8 169 SNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKgKELLAQKLPLWQQACADPSKIP 237 human
Q6UXY1 159 NRLHAQMQAFVSESQRAAELEEKRRYRFLAEKHLLLSNTFLQFFGRaRGMLQNRVLLWKEQ-SEASRSP 226 human
Q765P7 172 NDMYLLLEETEKQAVRRALIEERGRFCTFITFLQPVVNGELTMLGE-ITHLQGIIDDLVVLTAEPHKLP 239 human
2D1L_A 177 NDKYLLLEETEKQAVRKALIEERGRFCTFISXLRPVIEEEISXLGE-ITHLQTISEDLKSLTXDPHKLP 244 house mouse
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap